Protein Alignment GBE1 and GLC3

DIOPT Version :10

• Sequence 1: NP_000149.4
• Gene: GBE1 / 2632
• HGNCID: 4180
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_010905.1
• Gene: GLC3 / 856705
• SGDID: S000000737
• Length: 704
• Species: Saccharomyces cerevisiae
• Alignment Length: 698
• Identity: 409/698 - (58%)
• Similarity: 498/698 - (71%)
• Gaps: 26/698 - (3%)

Human    24 DVPELAR-LLEIDPYLKPYA-VDFQRRYKQFSQILKNIGENEGG----IDKFSR-GYESFGVHRC 81
            ::|:..: .:|.||:|||:| |..:|||.....:.........|    :.||:| .|:|:|:|..
Yeast     3 NIPDNVKGAVEFDPWLKPFADVLSERRYLADKWLYDITHATPDGSYQSLSKFARDSYKSYGLHAN 67

Human    82 AD-GGLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLD-YGKWELYIPPKQNKSVLVPHGSKLKV 144
            .: ..:..|||||.||..||.||||.|:..|:..|..| :|.:.:.:.|..|....:||.||:||
Yeast    68 PETKEITYKEWAPNAERAFLVGDFNNWDTTSHELKNKDEFGNFTITLHPLPNGDFAIPHDSKIKV 132

Human   145 VITSKSGEILYRISPWAKYVVREGDNVN------YDWIHWDPEHSYEFKHSRPK---KPRSLRIY 200
            :.....|..::|:..|.....:.....:      |:...|:||:.|:|.|.|||   ...|||||
Yeast   133 MFILPDGSKIFRLPAWITRATQPSKETSKQFGPAYEGRFWNPENPYKFVHPRPKFSESVDSLRIY 197

Human   201 ESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGT 265
            |:||||||.|.|:.:||.||..||||||.|||:.||||||||||||||||||:|:|||||||:||
Yeast   198 EAHVGISSPEPKITTYKEFTEKVLPRIKYLGYDAIQLMAIMEHAYYASFGYQVTNFFAASSRFGT 262

Human   266 PEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFH--SGPRGTHDLWDSRLFA 328
            ||||:||:||||||||:|||||||||||||..||||||||:|..|||  |..||.|.|||||||.
Yeast   263 PEELKELIDTAHSMGILVLLDVVHSHASKNVEDGLNMFDGSDHQYFHSISSGRGEHPLWDSRLFN 327

Human   329 YSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQG--FSGDYSEYFGLQ---VDED 388
            |..:|:.||||:|:.::::.|:||||||||||||||.|||||.|  |||||:||....   ||.:
Yeast   328 YGKFEVQRFLLANLAFYVDVYQFDGFRFDGVTSMLYVHHGVGAGGSFSGDYNEYLSRDRSFVDHE 392

Human   389 ALTYLMLANHLVHTLCPD-SITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKD 452
            ||.||||||.|||.:.|: ::|:||||||.|.||.|.|.||.|||||||||:||.||:|:||.||
Yeast   393 ALAYLMLANDLVHEMLPNLAVTVAEDVSGYPTLCLPRSIGGTGFDYRLAMALPDMWIKLIKEKKD 457

Human   453 EDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI 517
            ::|.||.||||||||||.||.:||.|||||||||||:||||||||.|||:|:||...:.||||||
Yeast   458 DEWEMGSIVYTLTNRRYGEKVVAYCESHDQALVGDKTLAFWLMDAAMYTDMTVLKEPSIVIDRGI 522

Human   518 QLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNN 582
            .||||||||||.||||.||||.|||||||||||||...|.:||.||||||:|.||.||||:.||.
Yeast   523 ALHKMIRLITHSLGGEAYLNFEGNEFGHPEWLDFPNVNNGDSYKYARRQFNLADDPLLRYQNLNE 587

Human   583 FDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYRVGTALPGKFK 647
            |||.|...|:|:.||...|||||.||||:|:|.|||..|||||||||:.||:|||||....|.:.
Yeast   588 FDRSMQLCEKRHKWLNTKQAYVSLKHEGDKMIVFERNNLLFIFNFHPTNSYSDYRVGVEKAGTYH 652

Human   648 IVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALIL 695
            |||:||.||:|||.|::.|::||:...|.|.|...|.|||||||||:|
Yeast   653 IVLNSDRAEFGGHNRINESSEFFTTDLEWNNRKNFLQVYIPSRVALVL 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBE1	NP_000149.4	PLN02447	2..699	CDD:215246	409/698 (59%)
GLC3	NP_010905.1	PLN02447	9..702	CDD:215246	408/692 (59%)