Protein Alignment GBE1 and AGBE

DIOPT Version :10

• Sequence 1: NP_000149.4
• Gene: GBE1 / 2632
• HGNCID: 4180
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_788342.1
• Gene: AGBE / 326264
• FlyBaseID: FBgn0053138
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 418/683 - (61%)
• Similarity: 524/683 - (76%)
• Gaps: 6/683 - (0%)

Human    22 LADVPELARLLEIDPYLKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGL 86
            :|:..::.:|.|.|.||:|:..:.:||:......|..|.::|||:|.||..|:.:|:|...|..:
  Fly     1 MAEAKDIEKLFETDGYLRPFEHEIRRRHGVLEDWLNKINQSEGGLDGFSTAYKHYGLHFQPDNSV 65

Human    87 YCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSG 151
            ..:||||||..|:||||||.|:..|:|:||||:|||||::||.::.|..:.|.|::|::|.:.||
  Fly    66 IAREWAPGARDVYLTGDFNNWHWESHPFKKLDFGKWELHLPPNEDGSPAIKHLSEIKIIIRNHSG 130

Human   152 EILYRISPWAKYVVR----EGDNVNYDWIHWDPE--HSYEFKHSRPKKPRSLRIYESHVGISSHE 210
            ::|.|:||||||||:    ....|||....|:|.  ..|:.:|..|.:|:||||||.||||:|.|
  Fly   131 QLLDRLSPWAKYVVQPPKSANQGVNYKQYVWEPPSYERYQRQHPGPPRPKSLRIYECHVGIASQE 195

Human   211 GKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDT 275
            .:|.||..|...::||||..||||||:|||||||||||||||:|||:|||||||.||:|:.::|.
  Fly   196 PRVGSYDEFADRIVPRIKRQGYNCIQVMAIMEHAYYASFGYQVTSFYAASSRYGNPEQLKRMIDV 260

Human   276 AHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLS 340
            |||.|:.|||||||||||||..||||.||||:||:||.|.||.|.|||||||.|..:|:||||||
  Fly   261 AHSHGLFVLLDVVHSHASKNVQDGLNQFDGTNSCFFHDGARGEHSLWDSRLFNYVEYEVLRFLLS 325

Human   341 NIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCP 405
            |:|||.:||.|||:|||||||||||..|:|:||||||:|||||.||.|||.||.|||||:||:..
  Fly   326 NLRWWHDEYNFDGYRFDGVTSMLYHSRGIGEGFSGDYNEYFGLNVDTDALNYLGLANHLLHTIDS 390

Human   406 DSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYL 470
            ..|||||||||||.||.|:|:||.||||||.||||||||:||||..|::|:||::|:||||||::
  Fly   391 RIITIAEDVSGMPTLCRPVSEGGIGFDYRLGMAIPDKWIELLKEQSDDEWDMGNLVHTLTNRRWM 455

Human   471 EKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGY 535
            |..:||||||||||||||::||||||.||||:||.|:..:.:||||:.||||||||||.||||.|
  Fly   456 ENTVAYAESHDQALVGDKTIAFWLMDKEMYTHMSTLSDSSVIIDRGLALHKMIRLITHALGGEAY 520

Human   536 LNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAP 600
            ||||||||||||||||||.|||:||||||||::|.|||||:||:||.|||.||..|||||||.:.
  Fly   521 LNFMGNEFGHPEWLDFPRVGNNDSYHYARRQWNLVDDDLLKYKYLNEFDRAMNEAEERYGWLHSG 585

Human   601 QAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDH 665
            .|:||.||||:||||||||||:|:|||||.:|:|.|||||...|.::.||.||...:|||.|:|.
  Fly   586 PAWVSWKHEGDKIIAFERAGLVFVFNFHPQQSFTGYRVGTNWAGTYQAVLSSDDPLFGGHNRIDA 650

Human   666 STDFFSEAFEHNGRPYSLLVYIPSRVALILQNV 698
            :....|....:.||...:.||.|||.|::...|
  Fly   651 NCKHPSNPEGYAGRSNFIEVYTPSRTAVVYARV 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBE1	NP_000149.4	PLN02447	2..699	CDD:215246	418/683 (61%)
AGBE	NP_788342.1	PLN02447	9..685	CDD:215246	417/675 (62%)