Protein Alignment GBE1 and aah3

DIOPT Version :10

• Sequence 1: NP_000149.4
• Gene: GBE1 / 2632
• HGNCID: 4180
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_587976.1
• Gene: aah3 / 2539415
• PomBaseID: SPCC63.02C
• Length: 564
• Species: Schizosaccharomyces pombe
• Alignment Length: 533
• Identity: 115/533 - (21%)
• Similarity: 185/533 - (34%)
• Gaps: 172/533 - (32%)

Human   222 NVLPRIKGLGYNCIQLMAI-------MEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSM 279
            |.|..|:.:|:|.|.:..|       ::.|.||..||..|.:.:.:..:||.::|..|:..||..
pombe    68 NKLDYIEDMGFNAIWISPIDKNIEGDIDGAGYAYHGYWNTDYESLNEHFGTEDDLVSLITAAHKA 132

Human   280 GIIVLLD-VVHSHA-SKNSAD----GLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSW------ 332
            ||.|:|| :|:|.| :...||    .||.|:  ...|||.......|:.|:.......|
pombe   133 GIWVMLDSIVNSMALAPPLADADYSSLNPFN--KESYFHPYCLIDWDITDNETNVMDCWQDSGVL 195

Human   333 ---------EILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDED 388
                     ::..:|..:.:..:.:|.|||.|.|.|..|.|       .|..|:.:..|:....:
pombe   196 LADLDVESSDVSSYLSDHFKSLISKYDFDGLRIDAVKMMNY-------TFFPDFVDATGVYSVGE 253

Human   389 ALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQ---------GGGGFDYRLAMAIPDKWI 444
            ..:|             |..|:...:|.:|.:.:...|         .|.||..          |
pombe   254 VFSY-------------DPDTMCSYMSVLPGVTNYFLQLYINFSFTATGAGFTL----------I 295

Human   445 QLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTN-----MS 504
            ...:|....:.:..|....||          :.|:||            |.....||:     |.
pombe   296 PTYQEVMASNCSKYDSTLMLT----------FIENHD------------LYRFPYYTSDQSQIMG 338

Human   505 VLTPFTPVIDRGIQLHKMIRLITHGL-----GGEGYLNFMGNEFGHPE-WL-DFPRKGNNESY-- 560
            .|: |..:.|.       |..|.:|.     |||...|       .|. || |:.:  :|..|
pombe   339 ALS-FVLIWDG-------IPSIFYGQEQGFNGGEDPAN-------RPALWLTDYDQ--SNPYYTV 386

Human   561 ---HYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWL--------AAPQAYVSEKHEGNKII 614
               ..|.|:|.:|.|.                     .|:        :|...||.:|::  .::
pombe   387 IKTMVAFRKFVITQDP---------------------DWVTSTYQSIESAVDHYVGQKND--VLV 428

Human   615 AFERAGLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGR 679
            .|...|:        :.:.|.|.|.|      ....:...::..||:.|....|....|...||
pombe   429 MFNNMGV--------TNNLTIYEVET------NYTANEVVSDVFGHRTLTVGADKTLTASMTNG- 478

Human   680 PYSLLVYIPSRVA 692
             |.|::|..|:::
pombe   479 -YPLIMYPHSKMS 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBE1	NP_000149.4	PLN02447	2..699	CDD:215246	115/533 (22%)
aah3	NP_587976.1	AmyAc_euk_AmyA	23..400	CDD:200458	91/402 (23%)
		A_amylase_dom_C	<426..491	CDD:370390	17/81 (21%)