Protein Alignment GBA1 and Gba1

DIOPT Version :10

• Sequence 1: NP_000148.2
• Gene: GBA1 / 2629
• HGNCID: 4177
• Length: 536
• Species: Homo sapiens
• Sequence 2: NP_001121111.1
• Gene: Gba1 / 684536
• RGDID: 1589149
• Length: 515
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 452/516 - (87%)
• Similarity: 477/516 - (92%)
• Gaps: 1/516 - (0%)

Human    21 MAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSG 85
            ||....||.|.||:|||.||:|||||||||||||||||||||||.||.|.|||||||||||||||
  Rat     1 MAARFIGLFLFQAISWAYGAQPCIPKSFGYSSVVCVCNATYCDSLDPLTLPALGTFSRYESTRSG 65

Human    86 RRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSE 150
            ||||||.|.||||.||||||||||||:|||||||||||||||.||||||||||||.||||||||.
  Rat    66 RRMELSTGSIQANRTGTGLLLTLQPEEKFQKVKGFGGAMTDATALNILALSPPAQKLLLKSYFSS 130

Human   151 EGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLA 215
            |||.||||||||||||||||.|||||||:||||.||||||||||||||||||||:::.||:||.|
  Rat   131 EGIEYNIIRVPMASCDFSIRIYTYADTPNDFQLSNFSLPEEDTKLKIPLIHRALKMSPRPISLFA 195

Human   216 SPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLL 280
            |||||||||||||||||||||||.||||||:.||.||||||||||.|.::||||||||||||||.
  Rat   196 SPWTSPTWLKTNGAVNGKGSLKGHPGDIYHEAWANYFVKFLDAYATHNIKFWAVTAENEPSAGLF 260

Human   281 SGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVH 345
            :||||||||||.|||||||:.||||.||||: |:|:||:|||||||||.||:|||:|||||||||
  Rat   261 TGYPFQCLGFTAEHQRDFISHDLGPALANSS-HDVKLLILDDQRLLLPRWAQVVLSDPEAAKYVH 324

Human   346 GIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNL 410
            |||||||:|||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
  Rat   325 GIAVHWYMDFLAPAKATLGETHRLFPNMMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNL 389

Human   411 LYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 475
            ||||.||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
  Rat   390 LYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 454

Human   476 VASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 536
            |||:|.||:.|||:.|||||||||||||||||||||.|||:||:|||||||||||||||||
  Rat   455 VASEKTDLETVALIRPDGSAVVVVLNRSSKDVPLTISDPALGFMETISPGYSIHTYLWRRQ 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBA1	NP_000148.2	Glyco_hydro_30	117..466	CDD:307945	309/348 (89%)
		Glyco_hydro_30C	469..531	CDD:465376	52/61 (85%)
Gba1	NP_001121111.1	Glyco_hydro_30	97..445	CDD:451560	309/348 (89%)
		Glyco_hydro_30C	448..510	CDD:465376	52/61 (85%)