Protein Alignment IL1RAPL2 and CG45263

DIOPT Version :9

• Sequence 1: NP_059112.1
• Gene: IL1RAPL2 / 26280
• HGNCID: 5997
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_731246.2
• Gene: CG45263 / 50003
• FlyBaseID: FBgn0266801
• Length: 1876
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 104/523 - (19%)
• Similarity: 168/523 - (32%)
• Gaps: 180/523 - (34%)

Human    29 DG---CIDWSVDLKTYMALAGEPVR----------------------------------VKCALF 56
            ||   |...:.|..|..||..:|||                                  |||.
  Fly   141 DGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADAGALATVKCI-- 203

Human    57 YSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEED-SIWFHSAEAQDSGF---YTCV 117
                 ::|....:|   |.|:  .||.|...|..::..::.:: ..|..::..|.|..   :..:
  Fly   204 -----SHYGNPPAT---LKWF--LGDQEISPIHPQMNATEPDNPRTWSATSVVQVSAMRERHGDI 258

Human   118 LRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKK-------SDQEP 175
            ||.:.|....:....|.|....:.|...||.:...|:         |:::.|.       :|..|
  Fly   259 LRCAAYHESYTAKSVVVEARLDVKYAPSIRLIGSPEI---------DLEEDKDALVLRCVADANP 314

Human   176 --DVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTC----------------ELKYEGKL 222
              .:||     .:..||.|......|.::.|...|.|.|||                ::||..|:
  Fly   315 PASIVW-----RRAGRSEIASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQLDVKYPPKI 374

Human   223 VRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK---- 283
            :....:...||        |||              .|....|.|    .|...|...|::
  Fly   375 ISAGPDRLTTA--------PLF--------------SPAAFECLA----DGNPLPSFKWVQRMAH 413

Human   284 GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENR-NGRKHASV--- 344
            |.|::|      |..|.|              |:.|:|.......|.|...:. ||::..::
  Fly   414 GSKYVE------RGSESR--------------LVIDNVTYEYQGEYECRATSYINGQERVAISDP 458

Human   345 ----------LLRKKDLIYKIELAGGLGAIFLLLVLL-----VVIYKCYNIELMLFYR-QHFGAD 393
                      :||....::.:.:..|..|...::|..     .|.::..::.|..... ..|.||
  Fly   459 VSLQVVGAPQVLRLHPSLHTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRAD 523

Human   394 ETNDDNKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPER---DLIPSGT 455
            :...|.:| |.|||...:    |..|..:...:.|     |:|...|     .:|   .||..||
  Fly   524 DMQPDTRE-DCYLSTLHI----LHADEHDSRPYYL-----VVENERG-----TDRHAIHLIVEGT 573

Human   456 YME 458
            :.|
  Fly   574 FAE 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142	24/138 (17%)
		Ig2_IL1R_like	146..237	CDD:319309	24/115 (21%)
		IG_like	250..347	CDD:214653	19/114 (17%)
		TIR	402..563	CDD:307630	16/60 (27%)
CG45263	NP_731246.2	I-set	53..149	CDD:254352	3/7 (43%)
		Ig	198..281	CDD:299845	19/94 (20%)
		IG_like	302..368	CDD:214653	14/70 (20%)
		IGc2	302..357	CDD:197706	14/59 (24%)
		Ig	372..446	CDD:299845	23/119 (19%)
		Ig	475..568	CDD:299845	21/107 (20%)
		IG_like	478..570	CDD:214653	22/106 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910