DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IL1RAPL2 and vlc

DIOPT Version :9

Sequence 1:	NP_059112.1	Gene:	IL1RAPL2 / 26280	HGNCID:	5997	Length:	686	Species:	Homo sapiens
Sequence 2:	NP_001163056.1	Gene:	vlc / 46078	FlyBaseID:	FBgn0259978	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	182	Identity:	42/182 - (23%)
Similarity:	70/182 - (38%)	Gaps:	60/182 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   513 KGKVNCQEVESLKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSA---- 573
            :|:|   |::||:.| :|..  |:|....||...:|           :|:|..:|....:|
  Fly   244 RGQV---EIDSLQGS-ELAR--KFKQLSPSKDYGEF-----------RKKMQKKCSQSTTARIDE 291

Human   574 ---EQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSL 635
               ..||.|:|                    |||.|        ||..:.::.::|..:   |..
  Fly   292 PLHSPGLNGDL--------------------DLPVF--------RHLSQEFRAQLPTVS---PKR 325

Human   636 GNHHTYCNLPLTLL--NGQLPLNNTLKDTQEFHRNSSLLPLSSKELSFTSDI 685
            |...: |..|..||  |...|.:....:..  |.::.:..|:|:|...||:|
  Fly   326 GAPRS-CMAPDVLLVDNESSPDHGPTDEVD--HESTKMDKLASEEYISTSNI 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142
		Ig2_IL1R_like	146..237	CDD:319309
		IG_like	250..347	CDD:214653
		TIR	402..563	CDD:307630	13/49 (27%)
vlc	NP_001163056.1	GKAP	246..575	CDD:281368	41/180 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900