Protein Alignment IL1RAPL2 and Tl

DIOPT Version :9

• Sequence 1: NP_059112.1
• Gene: IL1RAPL2 / 26280
• HGNCID: 5997
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Alignment Length: 326
• Identity: 79/326 - (24%)
• Similarity: 137/326 - (42%)
• Gaps: 55/326 - (16%)

Human   355 IELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQH-----FGADETNDDNKEYDAYLSYTKVDQD 414
            |.||..:....||......:|..:..|:.::...|     |..:|..|.:|::||::||:..||.
  Fly   807 IALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQS 871

Human   415 TLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYI 479
            .:       |.:   ::|.:......::|.:.|||.:..|...|::.|.|..|||.||||:.::|
  Fly   872 FI-------EDY---LVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFI 926

Human   480 LRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWKGSKSSKL 544
             :..|:..|..:...:.|..|..::|:|..::: |.|...: |.||..:|:.:.:||.
  Fly   927 -KSEWARLEFRAAHRSALNEGRSRIIVIIYSDI-GDVEKLD-EELKAYLKMNTYLKWG------- 981

Human   545 NSKFWKHLVYEMPIKK------KEMLPRCHVLDSAEQGLFGEL---QPI-PSIAMTSTSATLVSS 599
            :..||..|.:.:|.::      ...|.:..:..|.:..|  ||   .|: |.:......||....
  Fly   982 DPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKL--ELIKPSPVTPPLTTPPAEATKNPL 1044

Human   600 QADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVP---SLGNHHTYCNLPLTLLNGQLPLNNTLKD 661
            .|.|....|..::.|.:...|      .|.|..|   |.||.|         :||...:|...|.
  Fly  1045 VAQLNGVTPHQAIMIANGKNG------LTNLYTPNGKSHGNGH---------INGAFIINTNAKQ 1094

Human   662 T 662
            :
  Fly  1095 S 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142
		Ig2_IL1R_like	146..237	CDD:319309
		IG_like	250..347	CDD:214653
		TIR	402..563	CDD:307630	42/166 (25%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		LRR_8	342..402	CDD:290566
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	368..391	CDD:275380
		LRR_8	390..450	CDD:290566
		leucine-rich repeat	392..415	CDD:275380
		leucine-rich repeat	416..439	CDD:275380
		leucine-rich repeat	440..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		LRR_8	477..534	CDD:290566
		leucine-rich repeat	499..520	CDD:275380
		leucine-rich repeat	523..552	CDD:275380
		LRRCT	561..619	CDD:214507
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587	42/157 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8062
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860