DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL1RAPL2 and Toll-6

DIOPT Version :9

Sequence 1:	NP_059112.1	Gene:	IL1RAPL2 / 26280	HGNCID:	5997	Length:	686	Species:	Homo sapiens
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	83/392 - (21%)
Similarity:	149/392 - (38%)	Gaps:	121/392 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   298 GEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGGL- 361
            |.:...:.:||:...::         .|.:..:|...|      |:.:||:|:.. |..|..|:
  Fly   996 GYLARFRNYLGQSSEKI---------IDASRVSCIYNN------ATSVLREKNGT-KCTLRDGVA 1044

Human   362 ---------GAIFLLLVL---------LVVIYKCYNIELMLFYRQHFGADETN------------ 396
                     |.:.||||.         |:....||..||.::      |..||
  Fly  1045 HYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIW------AHSTNCLMNFCYKSPRF 1103

Human   397 ----DDNKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYM 457
                |..:..|||.:|:.           ::|.|..::|...||...||:|.:..||:..:....
  Fly  1104 VDQLDKERPNDAYFAYSL-----------QDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYIT 1157

Human   458 EDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVE 522
            :.|....|.:::.::||:.:::... ||.||.:|.||. ||....:|:.|    |.|.:..::::
  Fly  1158 DALIEAAESAKQFVLVLSKNFLYNE-WSRFEYKSALHE-LVKRRKRVVFI----LYGDLPQRDID 1216

Human   523 -SLKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPI------KKKEMLPRCHVLDSAEQGLFGE 580
             .::..::..:.|:|.       :.|||:.|...:|:      ..|.::..|         |.|.
  Fly  1217 MDMRHYLRTSTCIEWD-------DKKFWQKLRLALPLPNGRGNNNKRVVSGC---------LSGR 1265

Human   581 LQPIPSIAMTSTS--------ATLVSSQADLPEFHPSDSMQIRHCC-----RGYKHEIPATTLPV 632
               .||:.|.:||        ..:....|...:...::...|..|.     ||||        |:
  Fly  1266 ---TPSVNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYK--------PI 1319

Human   633 PS 634
            |:
  Fly  1320 PT 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142
		Ig2_IL1R_like	146..237	CDD:319309
		IG_like	250..347	CDD:214653	7/48 (15%)
		TIR	402..563	CDD:307630	39/167 (23%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587	38/156 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10655
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8062
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860