Protein Alignment VPS33B and Vps33B

DIOPT Version :10

• Sequence 1: NP_061138.3
• Gene: VPS33B / 26276
• HGNCID: 12712
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_651395.1
• Gene: Vps33B / 43077
• FlyBaseID: FBgn0039335
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 643
• Identity: 143/643 - (22%)
• Similarity: 288/643 - (44%)
• Gaps: 91/643 - (14%)

Human    14 DFSMLKRL------ARDQLIYLLEQLPGKKDLFIEADLMSPLDRIANVSILKQHEVDKLYKVENK 72
            |.::.|:|      |:::|..:|..:||||:|.:|.||:.||:.:...|.||...:.::||.:..
  Fly     2 DLTLDKKLQGFQLVAQEKLCSILCSIPGKKELILEPDLIKPLEHVVTASWLKLKGIQRIYKHDAA 66

Human    73 PAL--SSNEQLCFLVR-------PRIKNMRYIASLVNADKLAGRTRK-YKVIFSPQKFYACEMVL 127
            .:|  |:::...:::|       ..:|.::.:||    :::...:.| |.::..|..:...:.:|
  Fly    67 QSLPRSADQVHIYMIRSVLGTFQTLLKQLQPVAS----EEMPDISMKMYHIVCVPSCYSYFQTLL 127

Human   128 EEEGIYGDVSCDEWAFSLLPLDVDLLSMELPEFFRDYFLEGDQRWINTVAQALHLLSTLYGPFPN 192
            |:.|:||.|....:.:..:..|..:||:|||..:...:|:.:...:..|||:|.||..:.|....
  Fly   128 EQAGLYGLVQLHHFNWDFIYFDQGVLSLELPNLYECLYLQKNTSPLPAVAQSLRLLQMICGQPSL 192

Human   193 CYGIGRCAKMAYELWRNLEEEEDGETKG--RRPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTF 255
            ....|..:....::.:.|     |:...  ..|:.|...::|||.|:..:|.:..:|.||:.:.|
  Fly   193 ILSFGHHSSQLMQMAKTL-----GKLPAPTNPPDYGGWLVIDRDKDYPASLLTPAIYAGLLLEVF 252

Human   256 RIKCGS--VDFGPE------------------VTSSDKSLKVLLNA-EDKVFNEIRNEHFSNVFG 299
            ....|.  ||....                  |.|:.|...:.||: .|:::.:.|.:.|:.|..
  Fly   253 EHSSGEILVDNSKNKIRSQRVELLQGKKSKIGVNSASKPCSIRLNSTSDEIYGDNRYKRFAQVSS 317

Human   300 FLSQKARNLQAQYDRRRGMDIKQMKNFVSQELKGLKQEHRLLSLHIGACESIMKKKTKQDFQELI 364
            .:..:.:.|..:..:...|.:.:|.::|:::|..|.:....:..|:.|.|.::  :...:|::|.
  Fly   318 LIHAQVKALGLELQKLNDMQLDEMHDYVARKLPKLTELKSKVLRHLNASEIVI--QMMGNFRKLQ 380

Human   365 KTEHALLEGFNIRESTSYIEEHIDRQVSPIESLRLMCLLSITENGLIPKDYRSLKTQYLQSYGPE 429
            ..|..:|...:.:...|.|:|.:........:|||:|||.... |:.|::.:.....|...:|.:
  Fly   381 TLEEDILNNDSRKRLLSEIDELLTTDGQRFNTLRLLCLLHHCV-GVAPEELQIFARNYCNLFGHQ 444

Human   430 HLLTFSNLRRAGLLTEQAPGDTLTAVESKV-SKLVTDKAAGKITDAFSSLAKRSNFRAISKKLNL 493
            .|..|..|.:||||..       ..||.|. :||:::....|.        :::.|:|.:.:|.|
  Fly   445 ELGVFQQLSQAGLLPP-------LVVEKKAPTKLLSNLPLPKF--------QQTEFQANANRLKL 494

Human   494 IPR----VDGEYDLK-----VPRDMAYVFGGAYVPLSCRIIEQVLERRSWQGLDEVVRLL----- 544
            :..    .||....|     :....::||.|.|:||..::...:|:..|.:.|...:.::
  Fly   495 LTSSGDGQDGGSSSKSQSSGLQTCPSFVFNGTYIPLVAQLCSILLKINSAEELSSKLGMIEGLHL 559

Human   545 -----NCSDFAFTDMTKEDKASSES-----LRLILVVFLGGCTFSEISALRFLGREKG 592
                 ..:..|:....|.:..:.:.     ||.:.|..:||.:::||:|..|:.:..|
  Fly   560 HLDSGKITPKAYASQVKLNGVADQDMFPLRLRNLFVFIVGGASYAEIAACDFVAKLTG 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS33B	NP_061138.3	Sec1	37..610	CDD:460020	134/614 (22%)
Vps33B	NP_651395.1	Sec1	31..634	CDD:460020	134/614 (22%)