Protein Alignment VPS33B and car

DIOPT Version :9

• Sequence 1: NP_061138.3
• Gene: VPS33B / 26276
• HGNCID: 12712
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 654
• Identity: 181/654 - (27%)
• Similarity: 304/654 - (46%)
• Gaps: 85/654 - (12%)

Human     3 FPHRPDAPELPDFSMLKRLARDQLIYLLEQLPGKKDLFIEADLMSPLDRIANVSILKQHEVDKLY 67
            |||.....:..:..:|:..|..:|:..|:::.|.|.:.::..::.|||.:....:.....:..|
  Fly     2 FPHLKGHGQRVNLQLLQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTRPKLFADRGIRLL- 65

Human    68 KVENKPALSSNEQLC---FLVRPRIKNMRYIASLVNADKLAGRTRKYKVIFSPQKFYACEMVLEE 129
              ..||.|....::.   :::|||:..|..:|:.|.|...|...|:|.::|:|::...|...||.
  Fly    66 --ALKPELHLPREVANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLEV 128

Human   130 EGIYGDV-SCDEWAFSLLPLDVDLLSMELPEFFRDYFLEGDQRWINTVAQALHLLSTLYGPFPNC 193
            .|:.|.. :.:|.|::.|||||||:|||:|..|||..::||...:...|..|..|..|||..|..
  Fly   129 SGVLGSFGNIEELAWNYLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKI 193

Human   194 YGIGRCAKMAYELWRNLEEEEDGETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTFRIK 258
            ||.|..|...:|..:.|..:|.....|.:..:..:.||||.:|.::.|.:|:.||||:|:.:.|:
  Fly   194 YGKGEFAHRVWEHAKQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIR 258

Human   259 -----------------CGSVDFGPEVTSSDKSL------KVLLNAEDKVFNEIRNEHFSNVFGF 300
                             .|....||.|..|...|      .:||::.::::.|:||:||:.|...
  Fly   259 QNKLTLPAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKL 323

Human   301 LSQKARNLQAQ-YDRRRGMDIKQMKNFVSQELKGLKQEHRLLSLHIGACESIMKKKTKQDFQELI 364
            |::|||.:..| :...:...::::|:||...|..|..:.:..|.|......:.::.....|.:.:
  Fly   324 LARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDL 388

Human   365 KTEHALLEGFNIRESTSYIEEHIDRQVSPIESLRLMCLLSITENGLIPKDYRSLKTQYLQSYGPE 429
            ..|...:...:|.:.::|||:.|..:|.....|||:|:.....:|...|.....|.:.:..||.|
  Fly   389 AAEQEFMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLE 453

Human   430 HLLTFSNLRRAGLLTEQAPGDTLTAVESKVSKLVTDKAAGKITDAFSSLAKRSNFRAISKKLNLI 494
            .|||.|||.::|||                 .|.|:..|               :..:.|.|:|
  Fly   454 VLLTISNLEKSGLL-----------------HLQTESRA---------------YSVLRKTLHL- 485

Human   495 PRVDGEYDLKVPRDMAYVFGGAYVPLSCRIIEQVLERRSWQGLDEVVRLLNCSDFAFTDMTKE-- 557
             .||...::: |:|::||. ..|.||:.||:|..|:...||.|...:.  |.....|.|...:
  Fly   486 -TVDDNVEIE-PKDISYVH-SFYAPLTARIVEHSLKPLGWQTLKSQIN--NLPGPTFEDFQAQLV 545

Human   558 --------DKASSESL----RLILVVFLGGCTFSEISALRFLG--REKGYRFIFLTTAVTNSARL 608
                    ...|..||    |::||.|:|||||:||:|||||.  .:....|:..||.|.|....
  Fly   546 GIGGRHTVTTVSEGSLLNVPRVVLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSF 610

Human   609 MEAM 612
            ::::
  Fly   611 LDSL 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS33B	NP_061138.3	Sec1	37..605	CDD:279352	172/611 (28%)
car	NP_001259707.1	Sec1	36..606	CDD:279352	172/610 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53951
OrthoDB	1	1.010	-	-		D406738at2759
OrthoFinder	1	1.000	-	-		FOG0002117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1571
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830