Protein Alignment HIBCH and Echs1

DIOPT Version :10

• Sequence 1: NP_055177.2
• Gene: HIBCH / 26275
• HGNCID: 4908
• Length: 386
• Species: Homo sapiens
• Sequence 2: NP_610910.1
• Gene: Echs1 / 36536
• FlyBaseID: FBgn0033879
• Length: 295
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 83/346 - (23%)
• Similarity: 137/346 - (39%)
• Gaps: 91/346 - (26%)

Human     8 RLMSRFNAFKRTNTILHHLRMSKHTDAAEEVLLEKKGCTGVITLNRPKFLNALTLNMIRQIYPQL 72
            ::.:||:: ..||....:::        .||..|.|. .|||||||||.||||...:::::...|
  Fly    24 QVATRFSS-SSTNNNWEYIK--------TEVAGEGKN-VGVITLNRPKALNALCNGLMKELSTAL 78

Human    73 KKWEQDPETFLIIIKGAGGKAFCAGGDIRVISEAEKAKQKIAPVFFR--EEYMLNN--AVGSCQK 133
            :::.:|.....|::.|: .|||.||.||         |:.:...:.:  :...||:  .|...||
  Fly    79 QQFSKDKTISAIVLTGS-EKAFAAGADI---------KEMVGNTYSQCIQGNFLNDWTEVARTQK 133

Human   134 PYVALIHGITMGGGVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGK-LGYFLAL 197
            |.:|.::|..:|||..|::......|.:|..|..||.|:|..|..||...|.|:.|| ....:.|
  Fly   134 PIIAAVNGYALGGGCELAMMCDIIYAGDKAKFGQPEIALGTIPGAGGTQRLTRVVGKSKAMEMCL 198

Human   198 TGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLENYHTESKIDRDKSFILE 262
            ||..:..::..:.|:|:..|.:::|                    :.|......||....:.|::
  Fly   199 TGNMIGAQEAEKLGLASKVVPADQL--------------------LGEAVKLGEKIGTHSNLIVQ 243

Human   263 EHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEVLT 327
            ...:.:|:.:..                                              ||||.|.
  Fly   244 LCKEAVNTAYET----------------------------------------------TLQEGLK 262

Human   328 MEYRLSQACMRGHDFHEGVRA 348
            .|.|...|.....|..||:.|
  Fly   263 FERRTFHATFSTADRKEGMTA 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIBCH	NP_055177.2	ECH_2	46..376	CDD:465024	75/308 (24%)
Echs1	NP_610910.1	crotonase-like	37..294	CDD:474030	79/332 (24%)