Protein Alignment HIBCH and CG4592

DIOPT Version :10

• Sequence 1: NP_055177.2
• Gene: HIBCH / 26275
• HGNCID: 4908
• Length: 386
• Species: Homo sapiens
• Sequence 2: NP_609324.2
• Gene: CG4592 / 34317
• FlyBaseID: FBgn0032162
• Length: 287
• Species: Drosophila melanogaster
• Alignment Length: 315
• Identity: 63/315 - (20%)
• Similarity: 116/315 - (36%)
• Gaps: 75/315 - (23%)

Human    17 KRTNTIL---HHLRMSKHTDAAEEVLLEKKGCTGVITL--NRPKFLNALTLNMIRQIYPQLKKWE 76
            :|...||   ..||...:...::...:|....:|:.||  |.|. :|.||:.::..:...:.:.|
  Fly    11 RRIKPILCGGQSLRSLANGATSKLTTIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIE 74

Human    77 QDPETFLIIIKGAGGKAFCAGGDIRVISEAEKAKQKIAPVFFREEYMLNNAVGSCQKPYVALIHG 141
            .:....| |:..:..|.|.||.|:..:...:..:.::....|::.::   |:..|..|..|.|:|
  Fly    75 SNKSRGL-ILTSSNDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWL---ALHLCGLPTAAAING 135

Human   142 ITMGGGVGLSVHGQFRVATEKCLFAMPETAIGL----FPDVGGGYF-------LPRL-------Q 188
            .:...|..|:...::||       .:|...||:    |..|...:.       |||.       |
  Fly   136 HSPAAGCVLATACEYRV-------MLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQ 193

Human   189 GKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAM-LEEDLLALKSPSKENIASVLENYHTESK 252
            |||                        |...|.|.: |.:::...|..:....|:.:..:...:.
  Fly   194 GKL------------------------FASQEALDVGLVDEIACSKEEALSKCAAFIATFDKTNP 234

Human   253 IDR----------DKSFILEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLK 297
            :.|          |...:|::....:..|     |:.:...|.|:|....||.||
  Fly   235 VARCLTKRMCREPDVRELLQDRAADLKEC-----VDYVTTPLFQEGLCAHLEGLK 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIBCH	NP_055177.2	ECH_2	46..376	CDD:465024	57/283 (20%)
CG4592	NP_609324.2	crotonase-like	43..287	CDD:474030	57/283 (20%)