Protein Alignment HIBCH and hach-1

DIOPT Version :10

• Sequence 1: NP_055177.2
• Gene: HIBCH / 26275
• HGNCID: 4908
• Length: 386
• Species: Homo sapiens
• Sequence 2: NP_741143.1
• Gene: hach-1 / 175766
• WormBaseID: WBGene00017301
• Length: 386
• Species: Caenorhabditis elegans
• Alignment Length: 367
• Identity: 182/367 - (49%)
• Similarity: 255/367 - (69%)
• Gaps: 12/367 - (3%)

Human    27 RMSKHTDAA--EEVLLEKKGCTGVITLNRPKFLNALTLNMIRQIYPQLKKWEQDPETFLIIIKGA 89
            :||....||  .|:|::..|...|:||||||.||||.|.|:|:.||:|:.|....:..|:|:||:
 Worm    23 KMSFSVSAAAKSEILVDTHGSKKVVTLNRPKALNALNLEMVREFYPKLQAWNSSSDVDLVILKGS 87

Human    90 GGKAFCAGGD----IRVISEAEKAKQ-KIAPVFFREEYMLNNAVGSCQKPYVALIHGITMGGGVG 149
            |.||||||||    :|...::|..|: .:...||||||:||:.:|:..|.||.||.||.||||.|
 Worm    88 GDKAFCAGGDVLAVVRSFKDSESGKECTMHKDFFREEYILNHLIGTLNKQYVCLIDGIVMGGGCG 152

Human   150 LSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIAT 214
            |||:|:|||||||.:.||||||:||||||||.|||.||:|.||.:|||||:||.|.|.:.||:||
 Worm   153 LSVNGRFRVATEKTMLAMPETALGLFPDVGGSYFLSRLKGNLGMYLALTGYRLLGADAFHAGLAT 217

Human   215 HFVDSEKLAMLEEDLLALKSPSKENIASVLENYHTESKIDRDKSFILEEHMDKINSCFSANTVEE 279
            |||:|.:||.||::|:.:|..::.::..|:.::..: ||   ..|.|.:::.:|...|.|.:|||
 Worm   218 HFVESSELAKLEKELVNIKDVTENSVDEVIRSFEPK-KI---PEFSLSKNLAQIRDSFKAKSVEE 278

Human   280 IIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHE 344
            |:.:|::|||.:|.:|...:.||||||||:|.||:.|||..:..::.||||||:|..:...||||
 Worm   279 ILASLEKDGSDWAKKQAATLGKMSPTSLKVTHRQITEGSKMSYAKIFTMEYRLTQRFLADKDFHE 343

Human   345 GVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSL-GSSDLK 385
            |.||:|:|||:.|||.||.|.:|.:..::|:|..| .:||||
 Worm   344 GCRAILVDKDRKPKWNPATLADVKDSVVDNYFSPLPNNSDLK 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIBCH	NP_055177.2	ECH_2	46..376	CDD:465024	169/334 (51%)
hach-1	NP_741143.1	ECH_2	46..375	CDD:465024	169/332 (51%)