Protein Alignment GATA4 and srp

DIOPT Version :10

• Sequence 1: NP_001295022.1
• Gene: GATA4 / 2626
• HGNCID: 4173
• Length: 443
• Species: Homo sapiens
• Sequence 2: NP_732100.2
• Gene: srp / 41944
• FlyBaseID: FBgn0003507
• Length: 1264
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 144/496 - (29%)
• Similarity: 186/496 - (37%)
• Gaps: 176/496 - (35%)

Human    11 HGPPPGAYEAGGPG----AFMHGAGAASSPV--YVP------------------TPRVPSSVLGL 51
            :|.|..::..||.|    ||...|...|..|  |.|                  |.....:.||:
  Fly   607 YGSPRSSHSGGGGGGTLPAFQRIAYPNSGSVERYAPITNYRGQNDTWFDPLSYATSSSGQAQLGV 671

Human    52 SYLQGGGAGSASGGASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAYTPPPVSPRFSFPGTTGS 116
                |.|||..|.....|.:..||:.|           :.|.|||   |...|.     |||..|
  Fly   672 ----GVGAGVVSNVIRNGRAISAANAA-----------AAAAADG---TTGRVD-----PGTFLS 713

Human   117 LAAAAAAAAAREAA------AYSSGGGAAGAGLAGREQYGRAGFAGSYSSP-YPAYMADVGASWA 174
            .:|:.:|.||....      :::.|||       ||.:...:|.|.|||.| ..|..|...|..:
  Fly   714 ASASLSAMAAESGGDFYKPNSFNVGGG-------GRSKANTSGAASSYSCPGSNATSAATSAVAS 771

Human   175 AAAAASAGPFDSPVLHSLPGRANPAARHPNLVDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLC 239
            ..||.:|...|..|     .|||
  Fly   772 GTAATAATTLDEHV-----SRAN------------------------------------------ 789

Human   240 NACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHG 304
                               .||||||:|.||||:||.||.|:|||||..|||||||||||.|||.
  Fly   790 -------------------SRRLSASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHS 835

Human   305 VPRPLAMRKEGIQTRKRKPKNLNKSKTPAAPSGSESLPPASGA-SSNSSN-------ATTSSSEE 361
            |||||.|:|:.||.||||||.....|:.:....:.:....||: .:|..|       :....:::
  Fly   836 VPRPLTMKKDTIQKRKRKPKGTKSEKSKSKSKNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDD 900

Human   362 MRP---IKTEPGLSS-------HY----------GHSSSVSQ-------TFSVSAMSGHGPSIHP 399
            |:|   :|.....||       .|          .|||:.|.       :.|.|||| |....||
  Fly   901 MKPQLDLKPYNSYSSQPQQQLPQYQQQQQLLMADQHSSAASSPHSMGSTSLSPSAMS-HQHQTHP 964

Human   400 -------VLSALKLSPQG--YASPVS----QSPQTSSKQDS 427
                   :.|.|.:||..  ..||::    |..|:.|.|.|
  Fly   965 HQQQQQQLCSGLDMSPNSNYQMSPLNMQQHQQQQSCSMQHS 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GATA4	NP_001295022.1	GATA-N	1..205	CDD:461628	60/224 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..107		12/46 (26%)
		ZnF_GATA	217..267	CDD:238123	6/49 (12%)
		ZnF_GATA	271..322	CDD:238123	37/50 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..379		20/91 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..429		7/24 (29%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	37/50 (74%)