DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GATA4 and grn

DIOPT Version :9

Sequence 1:NP_001295022.1 Gene:GATA4 / 2626 HGNCID:4173 Length:443 Species:Homo sapiens
Sequence 2:NP_001262366.1 Gene:grn / 40962 FlyBaseID:FBgn0001138 Length:712 Species:Drosophila melanogaster


Alignment Length:478 Identity:169/478 - (35%)
Similarity:209/478 - (43%) Gaps:129/478 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    15 PGAYEAGGPGAFMHGAGAASSPVYVPTPRVPSSVLGLS-YLQGGGAGSASG-------------G 65
            |..|:| ...||||.....|:.:     ...|..|.:. .:|.|.|..:||             |
  Fly   199 PSEYQA-VMNAFMHQQATGSTSL-----TDASCALDIKPSIQNGSASGSSGSGTTHTSTPKQREG 257

Human    66 ASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAARE-- 128
            .:..::..:.|.:....||......|.....::.|....:...|......||:||.||:||..  
  Fly   258 TASTTNSSSNSSSSQQQQQQQQQQQQQQQQSSSNTTASSNTSASSSAAAASLSAAVAASAATSSN 322

Human   129 ------AAAYSSGGGAAGAGLAGREQYGRAGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDS- 186
                  |.||||||...|.|       |.:|..|..:|.|.:| ....|...|||.|:|..|.| 
  Fly   323 GLFDGTAQAYSSGGSGGGGG-------GGSGSGGYDTSSYASY-HHAAAHHQAAAVAAANMFQSS 379

Human   187 -----PVLHSL--------------------------------------------PGRANPAARH 202
                 .|.||:                                            .|.|...:.|
  Fly   380 SVAAAAVRHSMAAAQAHHHHHHHHSGHHHSGSSSGLHGLGGSVGGTAGMGSMSGNSGGAGSLSGH 444

Human   203 --------PNLVDMFD------DFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINR 253
                    .|.:|:..      ..:||||||||||.|||||||||||||||||||||:||||.||
  Fly   445 SGAGSNAGSNCLDVKPVRTKPRTSAEGRECVNCGATSTPLWRRDGTGHYLCNACGLYYKMNGQNR 509

Human   254 PLIKPQRRL------SASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMR 312
            |||||:|||      ||::|.|.|||||:|||||||||||.|||||||||||.|||.|.|||.|:
  Fly   510 PLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCNACGLYYKLHNVNRPLTMK 574

Human   313 KEGIQTRKRKPKNLNKSKTPAAPSGSESLPPASGASSNSSNATTSSSEEMRPIKTEPGLSSHYGH 377
            |||||||.||..:.:|.|...   |...||........          :.:|:....|...  |.
  Fly   575 KEGIQTRNRKLSSKSKKKKGL---GGGCLPIGGHLGMG----------DFKPLDPSKGFGG--GF 624

Human   378 SSSVSQTFSVSAMSGH-GPSIHP 399
            |:|::|       .|| ...:||
  Fly   625 SASMAQ-------HGHLSSGLHP 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GATA4NP_001295022.1 GATA-N 1..205 CDD:368398 59/269 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..107 8/59 (14%)
ZnF_GATA 217..267 CDD:238123 44/55 (80%)
ZnF_GATA 271..322 CDD:238123 42/50 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..379 15/63 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 410..429
grnNP_001262366.1 ZnF_GATA 470..517 CDD:214648 42/46 (91%)
ZnF_GATA 473..517 CDD:238123 39/43 (91%)
ZnF_GATA 529..578 CDD:214648 39/48 (81%)
ZnF_GATA 533..583 CDD:238123 42/49 (86%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000130
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1745
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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