Protein Alignment FBXW8 and RRT13

DIOPT Version :10

• Sequence 1: XP_024304705.2
• Gene: FBXW8 / 26259
• HGNCID: 13597
• Length: 665
• Species: Homo sapiens
• Sequence 2: NP_010988.1
• Gene: RRT13 / 856796
• SGDID: S000000868
• Length: 185
• Species: Saccharomyces cerevisiae
• Alignment Length: 158
• Identity: 41/158 - (25%)
• Similarity: 71/158 - (44%)
• Gaps: 39/158 - (24%)

Human   479 SKIL--VYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAH 541
            :|||  :|:|...|.|:.|         :.|||   ..:||.::||.:|..|..:..:.......
Yeast    60 AKILGAMYTLRGHRALVGL---------LGLSD---KFLVSASVDGSIRCWDANTYFLKHFFDHT 112

Human   542 QLR-VSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLW---EVYSG-HPVQHISFSSHSLITANVPY 601
            ||. ::|:.:.|..:|| |.|||::::|  :|..|.   :..|| ..|.::||..::|:.|
Yeast   113 QLNTITALHVSDEVLVS-GSEGLLNIYD--LNSGLLVRSDTLSGADNVWNVSFKDNTLVAA---- 170

Human   602 QTVMRNADLDSFTTHRRHRGLIRAYEFA 629
                         ..|..|.|:...:|:
Yeast   171 -------------VERDKRNLLEILDFS 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW8	XP_024304705.2	F-box_FBXW8	180..227	CDD:438906
		WD40	258..597	CDD:441893	36/124 (29%)
		WD40 repeat	280..320	CDD:293791
		WD40 repeat	327..364	CDD:293791
		WD40 repeat	503..539	CDD:293791	9/35 (26%)
		WD40 repeat	545..580	CDD:293791	11/37 (30%)
RRT13	NP_010988.1	WD40	<2..176	CDD:441893	38/147 (26%)
		WD40 repeat	15..71	CDD:293791	5/10 (50%)
		WD40 repeat	76..110	CDD:293791	10/45 (22%)
		WD40 repeat	118..150	CDD:293791	11/34 (32%)