DRSC/TRiP Functional Genomics Resources

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Protein Alignment GATA3 and grn

DIOPT Version :9

Sequence 1:NP_001002295.1 Gene:GATA3 / 2625 HGNCID:4172 Length:444 Species:Homo sapiens
Sequence 2:NP_001262366.1 Gene:grn / 40962 FlyBaseID:FBgn0001138 Length:712 Species:Drosophila melanogaster


Alignment Length:625 Identity:199/625 - (31%)
Similarity:256/625 - (40%) Gaps:250/625 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    11 VSHHHPAVLNGQHPDTHHPGLSH-------SYMDAAQYPLPEEVDVLFNIDGQGNH---VPPYYG 65
            ::|.|.::.:|........|:..       |.:|.:      ::...:.::..|:|   .|.|:.
  Fly    48 LAHSHHSLSSGASSAGSSVGVGSALGGGGGSGLDTS------DMSAFYALESNGHHRRYYPSYHQ 106

Human    66 NSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHH----TASPWNLSPFS---KTSIH 123
            ::     .|.|.||...|||||.......|||.      |.|    .||.|::..|:   :..:.
  Fly   107 HT-----SRMPSTHASPQVCRPHFHTPLSPWLT------SEHKSFAPASAWSMGQFACPQEPQVE 160

Human   124 H--GSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPD---------------------- 164
            |  |..|       .|..:.:.|.   |.|.||||||||.:||                      
  Fly   161 HKLGQMG-------QSHQTTAAGQ---HSFPFPPTPPKDSTPDSVQTGPSEYQAVMNAFMHQQAT 215

Human   165 ---------------PSL---STPGSAGSA----------------------------RQDEKEC 183
                           ||:   |..||:||.                            :|.:::.
  Fly   216 GSTSLTDASCALDIKPSIQNGSASGSSGSGTTHTSTPKQREGTASTTNSSSNSSSSQQQQQQQQQ 280

Human   184 LKYQVPLPDSMKLESSHSRGSMTAL------------------------------------GGAS 212
            .:.|.....|....||::..|.:|.                                    ||.|
  Fly   281 QQQQQQQSSSNTTASSNTSASSSAAAASLSAAVAASAATSSNGLFDGTAQAYSSGGSGGGGGGGS 345

Human   213 SSTHHPITTYPPY---------VPEYSSGLFPPSSL----------------------------- 239
            .|..:..::|..|         ....::.:|..||:                             
  Fly   346 GSGGYDTSSYASYHHAAAHHQAAAVAAANMFQSSSVAAAAVRHSMAAAQAHHHHHHHHSGHHHSG 410

Human   240 -------LGGS---PTGFGCKS-----------------------------RPKARSSTEGRECV 265
                   ||||   ..|.|..|                             |.|.|:|.||||||
  Fly   411 SSSGLHGLGGSVGGTAGMGSMSGNSGGAGSLSGHSGAGSNAGSNCLDVKPVRTKPRTSAEGRECV 475

Human   266 NCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRL------SAARRAGTSCANCQTT 324
            ||||||||||||||||||||||||||:||||||||||||||||      |||:|||||||||:||
  Fly   476 NCGATSTPLWRRDGTGHYLCNACGLYYKMNGQNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTT 540

Human   325 TTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKV---------H 380
            |||||||||:|:||||||||||||||:|||||||||||||||||:||||||.|.:         |
  Fly   541 TTTLWRRNASGEPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKLSSKSKKKKGLGGGCLPIGGH 605

Human   381 DSLEDFPKNSSFNPA-----ALSRHMSSLSHISPFSHSSH 415
            ..:.||   ...:|:     ..|..|:...|:|...|.:|
  Fly   606 LGMGDF---KPLDPSKGFGGGFSASMAQHGHLSSGLHPAH 642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GATA3NP_001002295.1 Interaction with TBX21. /evidence=ECO:0000250|UniProtKB:P23772 1..258 78/446 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29 3/17 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..180 23/119 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..216 8/57 (14%)
ZnF_GATA 260..307 CDD:214648 45/46 (98%)
ZnF_GATA 263..313 CDD:238123 48/55 (87%)
Flexible linker 289..317 25/33 (76%)
ZnF_GATA 313..362 CDD:214648 44/48 (92%)
ZnF_GATA 317..367 CDD:238123 45/49 (92%)
YxKxHxxxRP. /evidence=ECO:0000250 345..354 7/8 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..390 17/36 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..444 1/1 (100%)
grnNP_001262366.1 ZnF_GATA 470..517 CDD:214648 45/46 (98%)
ZnF_GATA 473..517 CDD:238123 42/43 (98%)
ZnF_GATA 529..578 CDD:214648 44/48 (92%)
ZnF_GATA 533..583 CDD:238123 45/49 (92%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 82 1.000 Domainoid score I8437
eggNOG 1 0.900 - - E1_COG5641
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 277 1.000 Inparanoid score I2946
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1240204at2759
OrthoFinder 1 1.000 - - FOG0000130
OrthoInspector 1 1.000 - - otm42218
orthoMCL 1 0.900 - - OOG6_109197
Panther 1 1.100 - - O PTHR10071
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1745
SonicParanoid 1 1.000 - - X385
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.860

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