Protein Alignment FAM50B and CG12259

DIOPT Version :10

• Sequence 1: NP_036267.1
• Gene: FAM50B / 26240
• HGNCID: 18789
• Length: 325
• Species: Homo sapiens
• Sequence 2: NP_651595.1
• Gene: CG12259 / 43347
• FlyBaseID: FBgn0039557
• Length: 359
• Species: Drosophila melanogaster
• Alignment Length: 353
• Identity: 193/353 - (54%)
• Similarity: 268/353 - (75%)
• Gaps: 29/353 - (8%)

Human     1 MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTV 65
            ||.|||...|||||..|:||||.|::::|..|::|.||..| .:::.:|:.||||||.:|||||:
  Fly     1 MAHYKGAASEAGRAAQLMKKREIQQQEIEFRKKKIEEELKL-DKIENKFATHYDAVEQQLKSSTI 64

Human    66 GLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD- 129
            |||||::|||:||.:|||||::||:::..:::..|:..:..|.::.::||:|..|||.|||.::
  Fly    65 GLVTLDEMKAKQEDIVREREKKLAQKKDEKDREKQRALEAIQAEKNKQKRQIQALSFNLDDDEEE 129

Human   130 ----------------QADAAEAR-----------RAGNLGKNPDVDTSFLPDRDREEEENRLRE 167
                            |.|..:.:           :...:.|||||||||||||:|||:||||||
  Fly   130 EEEDDEDHDKKQLKIKQEDQPKPKWTEIKEDILPIKKKKICKNPDVDTSFLPDREREEQENRLRE 194

Human   168 ELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGV 232
            :|||||..|:.::|||::.:||||||||||||.|.::|||::.|||:|.|:.|||:|:||::...
  Fly   195 QLRQEWVMQQAELKDEDISITFSYWDGSGHRRNVLMKKGNSIYQFLQKCLELLRKEFIELKTVMA 259

Human   233 EQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSW 297
            :|||::||||||||:::|||||:.:|||||||||.||||||||::|||::||:|||||||:||||
  Fly   260 DQLMYVKEDLILPHHYSFYDFIVTKARGKSGPLFQFDVHDDVRMISDASVEKEESHAGKVLLRSW 324

Human   298 YEKNKHIFPASRWEAYDPEKKWDKYTIR 325
            ||:|||||||||||.|||.|.:|||||:
  Fly   325 YERNKHIFPASRWEPYDPTKSYDKYTIK 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FAM50B	NP_036267.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..111		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..160		14/33 (42%)
		XAP5	<141..324	CDD:461480	127/182 (70%)
CG12259	NP_651595.1	PTZ00121	<5..>199	CDD:173412	85/194 (44%)
		XAP5	110..351	CDD:461480	138/240 (58%)