DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIAM2 and CDC24

DIOPT Version :10

Sequence 1:NP_036586.3 Gene:TIAM2 / 26230 HGNCID:11806 Length:1701 Species:Homo sapiens
Sequence 2:NP_009359.1 Gene:CDC24 / 851190 SGDID:S000000039 Length:854 Species:Saccharomyces cerevisiae


Alignment Length:803 Identity:184/803 - (22%)
Similarity:295/803 - (36%) Gaps:264/803 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   955 KQMEALFSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNT 1019
            |::|.|              |..|..|..::..|::.|..|..||......:||       |.|.
Yeast    52 KRLEVL--------------PQLKPFLQLAYQSSEVLSERQSLLLSQKQHQELL-------KSNG 95

Human  1020 AN-DFSNV------PDITTGLKRSQTDG---TLDQVSHREKMEQTF-----------RSAEQITA 1063
            || |.|::      ..|:|.......:|   |....|....||.|.           ...:.:|.
Yeast    96 ANRDSSDLAPTLRSSSISTATSLMSMEGISYTNSNPSATPNMEDTLLTFSMGILPITMDCDPVTQ 160

Human  1064 L--------------------------------------------CR---SFNDSQ--------A 1073
            |                                            |:   :|||.:        |
Yeast   161 LSQLFQQGAPLCILFNSVKPQFKLPVIASDDLKVCKKSIYDFILGCKKHFAFNDEELFTISDVFA 225

Human  1074 NG-------------------------------MEGPRENQDPPPRSLARHLSDADRLRKVIQEL 1107
            |.                               |....:::..|.:|..:|    :...|:|:|.
Yeast   226 NSTSQLVKVLEVVETLMNSSPTIFPSKSKTQQIMNAENQHRHQPQQSSKKH----NEYVKIIKEF 286

Human  1108 VDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFN 1172
            |.||:.||.||..| :.|.:.|.:...:|.:|:..||.:|.:.::||:.||.:||        .|
Yeast   287 VATERKYVHDLEIL-DKYRQQLLDSNLITSEELYMLFPNLGDAIDFQRRFLISLE--------IN 342

Human  1173 TLETPSQFRKLLFSLGGSFLYYADHFKLYS----GFCANHIKVQKVLERAKTDKAFKAFLDARNP 1233
            .|..||:.|     :|..|::....||||.    |..|....:...|.:.:.|::.:..::    
Yeast   343 ALVEPSKQR-----IGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTLHKMRVDESQRFIIN---- 398

Human  1234 TKQHSSTLESYLIKPVQRVLKYPLLLKELV--SLTDQESEEHYHLTEALKAMEKVASHINEMQKI 1296
               :...|:|:|.|||||:.:||||:|||:  |..|..::|   |..||...:.:|..|||.|:.
Yeast   399 ---NKLELQSFLYKPVQRLCRYPLLVKELLAESSDDNNTKE---LEAALDISKNIARSINENQRR 457

Human  1297 YEDYGTVFDQLVAEQSG---TEKEVTELSMGELLMHSTVSWLNPFLSL--GKARKDLELTVFVFK 1356
            .|::     |:|.:..|   ..|.......||||....|     |:|.  ..:..:.|..|::|:
Yeast   458 TENH-----QVVKKLYGRVVNWKGYRISKFGELLYFDKV-----FISTTNSSSEPEREFEVYLFE 512

Human  1357 RAVIL----VYKENCK---LKKK-LPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTEN- 1412
            :.:||    |.|::..   |||| ..|.|..|.|.||.:.      .|..:...|..|.:.:.| 
Yeast   513 KIIILFSEVVTKKSASSLILKKKSSTSASISASNITDNNG------SPHHSYHKRHSNSSSSNNI 571

Human  1413 ----NSIWELIHTKSEI------EGRPETIFQLCCSDSESK---------TNIVKVI----RSI- 1453
                :|...:||:.:..      .....::|:|  |.:|.|         .|:.::|    ||: 
Yeast   572 HLSSSSAAAIIHSSTNSSDNNSNNSSSSSLFKL--SANEPKLDLRGRIMIMNLNQIIPQNNRSLN 634

Human  1454 -----LRE--NFRRHIKCELPLE--KTCKDRLV-PLKNRVPVSAKLASSRSLKVLKNSSSNEWTG 1508
                 ::|  ||....|.|...:  .:|..:|: .|||           ...|. ::.||...|.
Yeast   635 ITWESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDLKN-----------EQFKA-RHHSSTSTTS 687

Human  1509 ETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKE-SDILSDED 1572
            .|.|.:       |:.|.|.:...|   ...:|:.|      |..:|.|:.:.:|. ||:|    
Yeast   688 STAKSS-------SMMSPTTTMNTP---NHHNSRQT------HDSMASFSSSHMKRVSDVL---- 732

Human  1573 DDHRQTVKQG--SPTKDIEIQFQ 1593
             ..|:|....  |..|.|...|:
Yeast   733 -PKRRTTSSSFESEIKSISENFK 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM2NP_036586.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..250
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..293
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..417
PH1_Tiam1_2 505..631 CDD:269937
Tiam_CC_Ex 645..742 CDD:408184
Ubl1_cv_Nsp3_N-like 811..881 CDD:475130
PDZ 887..976 CDD:214570 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1092 6/60 (10%)
RhoGEF 1103..1292 CDD:214619 61/194 (31%)
PH2_Tiam1_2 1294..1466 CDD:269957 50/216 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1500..1556 12/55 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1568..1628 7/28 (25%)
CDC24NP_009359.1 CDC24 156..242 CDD:399412 8/85 (9%)
RhoGEF 282..453 CDD:214619 61/194 (31%)
PH_Scd1 455..667 CDD:270066 52/229 (23%)
PB1 779..853 CDD:214770
Blue background indicates that the domain is not in the aligned region.

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