DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TIAM2 and CDC24

DIOPT Version :9

Sequence 1:	NP_001371475.1	Gene:	TIAM2 / 26230	HGNCID:	11806	Length:	1701	Species:	Homo sapiens
Sequence 2:	NP_009359.1	Gene:	CDC24 / 851190	SGDID:	S000000039	Length:	854	Species:	Saccharomyces cerevisiae

Alignment Length:	803	Identity:	184/803 - (22%)
Similarity:	295/803 - (36%)	Gaps:	264/803 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   955 KQMEALFSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNT 1019
            |::|.|              |..|..|..::..|::.|..|..||......:||       |.|.
Yeast    52 KRLEVL--------------PQLKPFLQLAYQSSEVLSERQSLLLSQKQHQELL-------KSNG 95

Human  1020 AN-DFSNV------PDITTGLKRSQTDG---TLDQVSHREKMEQTF-----------RSAEQITA 1063
            || |.|::      ..|:|.......:|   |....|....||.|.           ...:.:|.
Yeast    96 ANRDSSDLAPTLRSSSISTATSLMSMEGISYTNSNPSATPNMEDTLLTFSMGILPITMDCDPVTQ 160

Human  1064 L--------------------------------------------CR---SFNDSQ--------A 1073
            |                                            |:   :|||.:        |
Yeast   161 LSQLFQQGAPLCILFNSVKPQFKLPVIASDDLKVCKKSIYDFILGCKKHFAFNDEELFTISDVFA 225

Human  1074 NG-------------------------------MEGPRENQDPPPRSLARHLSDADRLRKVIQEL 1107
            |.                               |....:::..|.:|..:|    :...|:|:|.
Yeast   226 NSTSQLVKVLEVVETLMNSSPTIFPSKSKTQQIMNAENQHRHQPQQSSKKH----NEYVKIIKEF 286

Human  1108 VDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFN 1172
            |.||:.||.||..| :.|.:.|.:...:|.:|:..||.:|.:.::||:.||.:||        .|
Yeast   287 VATERKYVHDLEIL-DKYRQQLLDSNLITSEELYMLFPNLGDAIDFQRRFLISLE--------IN 342

Human  1173 TLETPSQFRKLLFSLGGSFLYYADHFKLYS----GFCANHIKVQKVLERAKTDKAFKAFLDARNP 1233
            .|..||:.|     :|..|::....||||.    |..|....:...|.:.:.|::.:..::
Yeast   343 ALVEPSKQR-----IGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTLHKMRVDESQRFIIN---- 398

Human  1234 TKQHSSTLESYLIKPVQRVLKYPLLLKELV--SLTDQESEEHYHLTEALKAMEKVASHINEMQKI 1296
               :...|:|:|.|||||:.:||||:|||:  |..|..::|   |..||...:.:|..|||.|:.
Yeast   399 ---NKLELQSFLYKPVQRLCRYPLLVKELLAESSDDNNTKE---LEAALDISKNIARSINENQRR 457

Human  1297 YEDYGTVFDQLVAEQSG---TEKEVTELSMGELLMHSTVSWLNPFLSL--GKARKDLELTVFVFK 1356
            .|::     |:|.:..|   ..|.......||||....|     |:|.  ..:..:.|..|::|:
Yeast   458 TENH-----QVVKKLYGRVVNWKGYRISKFGELLYFDKV-----FISTTNSSSEPEREFEVYLFE 512

Human  1357 RAVIL----VYKENCK---LKKK-LPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTEN- 1412
            :.:||    |.|::..   |||| ..|.|..|.|.||.:.      .|..:...|..|.:.:.|
Yeast   513 KIIILFSEVVTKKSASSLILKKKSSTSASISASNITDNNG------SPHHSYHKRHSNSSSSNNI 571

Human  1413 ----NSIWELIHTKSEI------EGRPETIFQLCCSDSESK---------TNIVKVI----RSI- 1453
                :|...:||:.:..      .....::|:|  |.:|.|         .|:.::|    ||:
Yeast   572 HLSSSSAAAIIHSSTNSSDNNSNNSSSSSLFKL--SANEPKLDLRGRIMIMNLNQIIPQNNRSLN 634

Human  1454 -----LRE--NFRRHIKCELPLE--KTCKDRLV-PLKNRVPVSAKLASSRSLKVLKNSSSNEWTG 1508
                 ::|  ||....|.|...:  .:|..:|: .|||           ...|. ::.||...|.
Yeast   635 ITWESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDLKN-----------EQFKA-RHHSSTSTTS 687

Human  1509 ETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKE-SDILSDED 1572
            .|.|.:       |:.|.|.:...|   ...:|:.|      |..:|.|:.:.:|. ||:|
Yeast   688 STAKSS-------SMMSPTTTMNTP---NHHNSRQT------HDSMASFSSSHMKRVSDVL---- 732

Human  1573 DDHRQTVKQG--SPTKDIEIQFQ 1593
             ..|:|....  |..|.|...|:
Yeast   733 -PKRRTTSSSFESEIKSISENFK 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TIAM2	NP_001371475.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..250
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..293
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..417
		PH1_Tiam1_2	505..631	CDD:269937
		Tiam_CC_Ex	645..742	CDD:408184
		Ubiquitin_like_fold	811..881	CDD:421700
		PDZ_signaling	888..973	CDD:238492	3/17 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1070..1092		6/60 (10%)
		RhoGEF	1103..1292	CDD:214619	61/194 (31%)
		PH2_Tiam1_2	1294..1466	CDD:269957	50/216 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1500..1556		12/55 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1568..1628		7/28 (25%)
CDC24	NP_009359.1	CDC24	156..242	CDD:399412	8/85 (9%)
		RhoGEF	282..453	CDD:214619	61/194 (31%)
		PH_Scd1	455..667	CDD:270066	52/229 (23%)
		PB1	779..853	CDD:214770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I2312
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810