DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATA1 and pnr

DIOPT Version :9

Sequence 1:	NP_002040.1	Gene:	GATA1 / 2623	HGNCID:	4170	Length:	413	Species:	Homo sapiens
Sequence 2:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	297	Identity:	130/297 - (43%)
Similarity:	156/297 - (52%)	Gaps:	41/297 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    41 LDAAASSTAPSTATAAAAALAYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYP 105
            |.||::||:.|.:....||:..|       ||.....|..|    ...|.:..||...|.:|.:.
  Fly    32 LSAASASTSASASATHVAAVKMY-------HSSAVAAYTDL----AAAGSAASAGVGVGVSGYHQ 85

Human   106 ASTVCPTREDSPPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSS 170
            .:...|....|..|........||.:......||...        :..:....||:|.....:.|
  Fly    86 QAVNAPVYVPSNRQYNHVAAHFGSAAAQNAWTTEGFG--------SAHAQFYSPNAAVMMGSWRS 142

Human   171 TFFSPTG----SPLNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLY 231
            . :.|:|    ||..||          :.....|.||||||||.:|||||||.||||||||||||
  Fly   143 A-YDPSGFQRSSPYESA----------MDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLY 196

Human   232 HKMNGQNRPLIRPKKRLI---VSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNR 293
            |||||.|||||:|.|||:   .::|.|..||||.|.||||||||..|:|||||||||||||.|||
  Fly   197 HKMNGMNRPLIKPSKRLVSATATRRMGLCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNR 261

Human   294 PLTMRKDGIQTRNRKASGKGKKKRGSSLG-GTGAAEG 329
            ||.|||||||||.||....|.   ||::| |||:..|
  Fly   262 PLAMRKDGIQTRKRKPKKTGS---GSAVGAGTGSGTG 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATA1	NP_002040.1	Interaction with MED1 and CCAR1. /evidence=ECO:0000269\|PubMed:24245781	200..330		95/134 (71%)
		ZnF_GATA	202..247	CDD:214648	38/44 (86%)
		ZnF_GATA	203..247	CDD:238123	37/43 (86%)
		Required for interaction with ZFPM1	203..222		15/18 (83%)
		Interaction with CALCOCO1. /evidence=ECO:0000269\|PubMed:24245781	249..315		46/68 (68%)
		ZnF_GATA	<268..308	CDD:238123	33/39 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..327		18/30 (60%)
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	39/47 (83%)
		ZnF_GATA	168..212	CDD:238123	37/43 (86%)
		ZnF_GATA	223..270	CDD:214648	37/46 (80%)
		ZnF_GATA	226..276	CDD:238123	41/49 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840