DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAS6 and CG18735

DIOPT Version :9

Sequence 1:	NP_000811.1	Gene:	GAS6 / 2621	HGNCID:	4168	Length:	678	Species:	Homo sapiens
Sequence 2:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	63/312 - (20%)
Similarity:	86/312 - (27%)	Gaps:	125/312 - (40%)

- Green bases have known domain annotations that are detailed below.

Human    19 LLLLLAA-----ECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHL------------ERECV 66
            |||:||.     .||..:|..|.:..:.|....:.....|.:..|..|            :|||.
  Fly     6 LLLILATALGDLACATPSLRSASDPEKILNNLAQLRQSSFLDWIQSILGPEVPAEWSSPAKRECA 70

Human    67 EELCSREEAREVFENDPETD-YFYPRYL------------------------DCIN--------- 97
            |..|.....|.......||: :.||..:                        .|:|
  Fly    71 ECSCGNINTRHRIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCVNGFYHRLITV 135

Human    98 --------------------------KYGSPYTKN--SGFATCVQNLPDQ--------CTPNPCD 126
                                      ||.   |:|  |..|....|.|.:        |.|.|.:
  Fly   136 RLLEHNRQDSHVKIVDRRVSRVLIHPKYS---TRNFDSDIALIRFNEPVRLGIDMHPVCMPTPSE 197

Human   127 RKGTQACQDLMGNFFCLCKAGW-----GGRLCD--KDV-------NECSQENGGCLQICHN---- 173
            ....|..          ...||     ||.:.|  ::|       .||...|.|..:|..|
  Fly   198 NYAGQTA----------VVTGWGALSEGGPISDTLQEVEVPILSQEECRNSNYGESKITDNMICA 252

Human   174 ----KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCK-NLPGSYS 220
                :.|...|...||..:...|  ..|..:.|...:.||...| |.||.|:
  Fly   253 GYVEQGGKDSCQGDSGGPMHVLG--SGDAYQLAGIVSWGEGCAKPNAPGVYT 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAS6	NP_000811.1	Gla	53..92	CDD:306960	13/51 (25%)
		EGF_CA	118..153	CDD:238011	8/47 (17%)
		FXa_inhibition	160..195	CDD:317114	10/42 (24%)
		EGF_CA	197..>227	CDD:214542	9/25 (36%)
		vWFA	<232..273	CDD:320736
		LamG	298..450	CDD:238058
		Laminin_G_2	513..651	CDD:308045
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	44/236 (19%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	44/235 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910