DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GAS6 and tld

DIOPT Version :9

Sequence 1:NP_000811.1 Gene:GAS6 / 2621 HGNCID:4168 Length:678 Species:Homo sapiens
Sequence 2:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster


Alignment Length:335 Identity:74/335 - (22%)
Similarity:113/335 - (33%) Gaps:145/335 - (43%)


- Green bases have known domain annotations that are detailed below.


Human   145 KAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACG- 208
            |.|:...|. .||:||...:.||..:|.|..||:.|.|.:|:||.::|:||:|        ||| 
  Fly   581 KLGFSA
ALM-LDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCED--------ACGG 636

Human   209 --EARCKN-----------LPGSYSCLCD------------------EG--FAY----------- 229
              :|...|           .|.|..|:.:                  ||  |.|           
  Fly   637 VVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIY 701

Human   230 -----------------------SSQEKACR--------------------DVDECL--QGRCEQ 249
                                   :|::...|                    |||||.  .|.|:.
  Fly   702 SKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQH 766

Human   250 VCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSV-------------KSLY----- 296
            .|.|:.|||.|.|  |.|..|:::...|.: ..| .|.:..|.             :::|     
  Fly   767 RCRNTFGSYQCSC--RNGYTLAENGHNCTE-TRC-KFEITTSYGVLQSPNYPEDYPRNIYCYWHF 827

Human   297 ---LGRMFSGTPVIRLRFKRLQPTR-------LVAEFDFRTFDPEGILLFAGGHQ--------DS 343
               ||..      |:|.|...:...       .||.:|.|:.:...:.::.||.:        :.
  Fly   828 QTVLGHR------IQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNE 886

Human   344 TWIVLALRAG 353
            .::|||..||
  Fly   887 MFMVLATDAG 896

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAS6NP_000811.1 Gla 53..92 CDD:306960
EGF_CA 118..153 CDD:238011 2/7 (29%)
FXa_inhibition 160..195 CDD:317114 13/34 (38%)
EGF_CA 197..>227 CDD:214542 11/63 (17%)
vWFA <232..273 CDD:320736 18/62 (29%)
LamG 298..450 CDD:238058 15/71 (21%)
Laminin_G_2 513..651 CDD:308045
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808
Astacin 144..339 CDD:279708
CUB 388..474 CDD:214483
CUB 478..586 CDD:278839 2/4 (50%)
FXa_inhibition 595..630 CDD:291342 13/34 (38%)
CUB 634..750 CDD:278839 13/115 (11%)
FXa_inhibition 757..792 CDD:291342 13/36 (36%)
CUB 797..906 CDD:278839 20/107 (19%)
CUB 910..1023 CDD:278839
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.