DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAS6 and CG12951

DIOPT Version :9

Sequence 1:	NP_000811.1	Gene:	GAS6 / 2621	HGNCID:	4168	Length:	678	Species:	Homo sapiens
Sequence 2:	NP_649880.1	Gene:	CG12951 / 41110	FlyBaseID:	FBgn0037677	Length:	265	Species:	Drosophila melanogaster

Alignment Length:	249	Identity:	49/249 - (19%)
Similarity:	79/249 - (31%)	Gaps:	98/249 - (39%)

- Green bases have known domain annotations that are detailed below.

Human   451 LNGEDTTIQETVKVNTRMQCFSVTERGSFYPGS---GFAFYSLDYMRTPLDVGTESTWEVEVVAH 512
            :||.|:::.:        ..|.|:.|.  |.||   |.:..|..::.|              .||
  Fly    31 VNGTDSSVLK--------YPFVVSLRS--YDGSHSCGGSIISKHFVMT--------------AAH 71

Human   513 I---RPAADTGVLFAL-----WAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKV 569
            .   |||....:.|.:     ..|::..:...:...|:..|::....:.:|.||.
  Fly    72 CTNGRPADTLSIQFGVTNISAMGPNVVGIKKIIQHEDFDPTRQNANDISLLMVEE---------- 126

Human   570 CDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSA 634
                             ..|.||      ||.|.::           .|.|.||     ||.:.|
  Fly   127 -----------------PFEFDG------VSVAPVE-----------LPALAFA-----VPQSDA 152

Human   635 PVTAFYRGC----------MTL-EVNRRLLDLDEAAYKH---SDITAHSCPPVE 674
            .|.....|.          .|| ||:.::...:|...:|   :|...|.|..|:
  Fly   153 GVEGVLIGWGLNDTYGSVQDTLQEVSLKIYSDEECTSRHNGQTDPKYHICGGVD 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAS6	NP_000811.1	Gla	53..92	CDD:306960
		EGF_CA	118..153	CDD:238011
		FXa_inhibition	160..195	CDD:317114
		EGF_CA	197..>227	CDD:214542
		vWFA	<232..273	CDD:320736
		LamG	298..450	CDD:238058
		Laminin_G_2	513..651	CDD:308045	29/156 (19%)
CG12951	NP_649880.1	Tryp_SPc	29..257	CDD:214473	49/249 (20%)
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	49/249 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910