DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAS6 and MP1

DIOPT Version :9

Sequence 1:	NP_000811.1	Gene:	GAS6 / 2621	HGNCID:	4168	Length:	678	Species:	Homo sapiens
Sequence 2:	NP_001303421.1	Gene:	MP1 / 40541	FlyBaseID:	FBgn0027930	Length:	400	Species:	Drosophila melanogaster

Alignment Length:	268	Identity:	61/268 - (22%)
Similarity:	96/268 - (35%)	Gaps:	58/268 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    63 REC--VEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFAT---CVQN------- 115
            |||  :.||...||.       .|.|..:.:...|..:.|....|:..|..   |..|
  Fly    43 RECGYLFELLQSEEV-------TEQDRRFLQASQCGYRNGQVLEKHFCFTNVQICCANSRMRNQQ 100

Human   116 -------LPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQIC-H 172
                   .|.| |..|..|.||:.. .:..|    |...:|.|:...  ||.::.....:.:. :
  Fly   101 PQWGNHPQPTQ-TTKPTKRSGTKLL-PMAPN----CGENFGDRVVGG--NETTKREFPWMALIEY 157

Human   173 NKPGS---FHCSCHSGFELSSDGRTCQDIDEC-----ADSEACGEARCKNLPGSYSCLCDEGFAY 229
            .|||:   .||    |..|.:. |.......|     :|.|..| .|......|.:..|..|
  Fly   158 TKPGNVKGHHC----GGSLINH-RYVLTAAHCVSAIPSDWELTG-VRLGEWDASTNPDCTVG--- 213

Human   230 SSQEKACRD--VDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILP-CVPFSVAKS 291
            .:..:.|.:  ||..::.|...  ...||:.....:....|:|..::...:.||| |:| ::|..
  Fly   214 KNGRRDCNEPYVDYPVEERIPH--PQYPGNSRDQLNDIALLRLRDEVQYSDFILPVCLP-TLASQ 275

Human   292 VKSLYLGR 299
            ..:::|||
  Fly   276 HNNIFLGR 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAS6	NP_000811.1	Gla	53..92	CDD:306960	9/30 (30%)
		EGF_CA	118..153	CDD:238011	10/34 (29%)
		FXa_inhibition	160..195	CDD:317114	8/38 (21%)
		EGF_CA	197..>227	CDD:214542	7/34 (21%)
		vWFA	<232..273	CDD:320736	8/42 (19%)
		LamG	298..450	CDD:238058	2/2 (100%)
		Laminin_G_2	513..651	CDD:308045
MP1	NP_001303421.1	CLIP	29..91	CDD:288855	13/54 (24%)
		Tryp_SPc	137..394	CDD:214473	36/161 (22%)
		Tryp_SPc	138..397	CDD:238113	35/160 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910