DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAS6 and CG6865

DIOPT Version :9

Sequence 1:	NP_000811.1	Gene:	GAS6 / 2621	HGNCID:	4168	Length:	678	Species:	Homo sapiens
Sequence 2:	NP_001246825.1	Gene:	CG6865 / 40050	FlyBaseID:	FBgn0036817	Length:	285	Species:	Drosophila melanogaster

Alignment Length:	177	Identity:	32/177 - (18%)
Similarity:	55/177 - (31%)	Gaps:	65/177 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   334 LLFAGGH------QDSTWIVLA-----------LRAGRLE-------LQLRYNGVGRVTSSGP-- 372
            |:..|||      ....||:.|           ::..:::       ::...||:|    :||
  Fly    52 LMRRGGHFCGGTIISERWILTAGHCICNGLQQFMKPAQIQGVVGLHSIREYLNGIG----NGPDA 112

Human   373 -------VINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHE 430
                   ::.|..:..               .|....||:. :|.||.|...|:..:..|.....
  Fly   113 LRVDFKNIVPHPQYDC---------------NDVKHDIALL-ELVQPIRFSSHIQPSCVGSEEGH 161

Human   431 KDLVQPINPRLDGCMRSWNWL-------NGEDTTIQETVKVNTRMQC 470
            :.|.|..     |.:..|.|.       :..|...:.|||:.....|
  Fly   162 RSLEQEY-----GTVSGWGWTHENQAENDRSDVLRKATVKIWNNEAC 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAS6	NP_000811.1	Gla	53..92	CDD:306960
		EGF_CA	118..153	CDD:238011
		FXa_inhibition	160..195	CDD:317114
		EGF_CA	197..>227	CDD:214542
		vWFA	<232..273	CDD:320736
		LamG	298..450	CDD:238058	26/148 (18%)
		Laminin_G_2	513..651	CDD:308045
CG6865	NP_001246825.1	Tryp_SPc	34..276	CDD:214473	32/177 (18%)
CG6865	NP_001246825.1	Tryp_SPc	35..280	CDD:238113	32/177 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910