DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAS6 and crb-1

DIOPT Version :9

Sequence 1:NP_000811.1 Gene:GAS6 / 2621 HGNCID:4168 Length:678 Species:Homo sapiens
Sequence 2:NP_510822.1 Gene:crb-1 / 181771 WormBaseID:WBGene00000792 Length:1722 Species:Caenorhabditis elegans


Alignment Length:355 Identity:74/355 - (20%)
Similarity:117/355 - (32%) Gaps:125/355 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    62 ERECVE----ELCSREEAREVFENDPETDYFYPRYLDCINKYGSP-------YTKNSGFATCVQN 115
            |..|::    |||.:.:..|....|....:       |:.....|       ||     ....:.
 Worm  1314 ECNCMDGYSGELCEQRDVNECNHYDCNRGH-------CVMTVSGPACQCEMGYT-----GRFCEK 1366

Human   116 LPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNEC-------------SQEN--- 164
            |.:||:.|.|..:|  ||..:..|..|.|...|.|..|...::.|             :.||   
 Worm  1367 LLNQCSSNTCSSRG--ACSPVWNNTVCNCDNNWRGAHCQHQMDTCLDFPCNNDGVCRTNDENTFS 1429

Human   165 -------------------------GGCLQI---------------------------------- 170
                                     |.|:|:                                  
 Worm  1430 CECQKFFMGTRCEIEGSCLKAQCVHGECIQLSPETHTCSCNIGYEGDACDKKIDYCKAGPCLNGA 1494

Human   171 -CHNKPGSFHCSCHSGFELSSDGRTCQ-DIDECADSEACGEARCKNLPGSYSCLCD----EGFAY 229
             |.||...:.|:|..|||    |..|: :|||||.......|:|::....|.|:||    ||...
 Worm  1495 NCENKLTGYKCTCAVGFE----GADCEINIDECALEFCKNGAKCRDKINDYECVCDGTGFEGRNC 1555

Human   230 SSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKS 294
            ::....|.:.:.|:.|.    |.|:.|:|.|.|  |.|....:    |....||.....:.::.|
 Worm  1556 TTDINECANPNNCINGE----CTNTLGNYKCAC--RNGFIGPR----CSVRNPCTAQIASNNISS 1610

Human   295 LYLGRMFSGTPVIRLRFKRLQPTRLVAEFD 324
            :.........||:     :::..|.||:::
 Worm  1611 VTCVHGKCVNPVV-----QIEKNREVAKYE 1635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAS6NP_000811.1 Gla 53..92 CDD:306960 7/33 (21%)
EGF_CA 118..153 CDD:238011 12/34 (35%)
FXa_inhibition 160..195 CDD:317114 15/110 (14%)
EGF_CA 197..>227 CDD:214542 12/33 (36%)
vWFA <232..273 CDD:320736 11/40 (28%)
LamG 298..450 CDD:238058 5/27 (19%)
Laminin_G_2 513..651 CDD:308045
crb-1NP_510822.1 EGF_CA <132..161 CDD:238011
EGF_CA 163..199 CDD:238011
EGF_CA 408..439 CDD:238011
Laminin_G_2 582..694 CDD:280389
LamG 760..912 CDD:238058
LamG 1029..>1088 CDD:304605
EGF_CA 1175..1210 CDD:238011
EGF_CA 1482..1517 CDD:238011 9/38 (24%)
EGF_CA 1519..1556 CDD:238011 13/36 (36%)
EGF_CA 1558..1593 CDD:238011 11/44 (25%)
PHA03099 <1613..1682 CDD:165381 5/28 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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