DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PITPNC1 and rdgB

DIOPT Version :9

Sequence 1:	NP_036549.2	Gene:	PITPNC1 / 26207	HGNCID:	21045	Length:	332	Species:	Homo sapiens
Sequence 2:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	144/345 - (41%)
Similarity:	200/345 - (57%)	Gaps:	38/345 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQS-DRGEGVEVVQNEPFEDPHHGNGQFTEKRVYL 64
            ||:|||||.:||||:||:|.|||||:|.|.|:| ..|.|||::.|||::|...||||:|:|..::
  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPYKDGPGGNGQYTKKIYHV 65

Human    65 NSKLPSWARAVVPK-IFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEA 128
            .:.||.|.::::|| ...|.|:|||.||||.|.|||.|:.|||:.|||.|..:.|..|.:|....
  Fly    66 GNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPDNGYQDNVFQLSG 130

Human   129 KDV-EREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSH--------QP----- 179
            .|: .|.|..|||..|::....|.:.||||||.|:|||||.|.|.|.:.:        ||
  Fly   131 SDLRNRIVDVIDIVKDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNM 195

Human   180 -IMCSYKLVTVKFEVWGLQTRVEQFVHKV-VRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQ 242
             :|.:||:..|:|..||:||::|:|:|.| :|.::|..||||:||.|||:.:|::::||.||.||
  Fly   196 SLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMMLRAHRQAWAWQDEWFGLTIEDIRELERQTQ 260

Human   243 EATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPET---L 304
            .|..||:|        ........||.....|..:|..||...|         ||||||..   :
  Fly   261 LALAKKMG--------GGEECSDDSVSEPYVSTAATAASTTGSE---------RKKSAPAVPPIV 308

Human   305 TLPDPEKKATLNLPGMHSSD 324
            |...|..:|:.:..|....|
  Fly   309 TQQPPSAEASSDEEGEEEED 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PITPNC1	NP_036549.2	SRPBCC_PITPNC1_like	2..250	CDD:176899	124/265 (47%)
PITPNC1	NP_036549.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..332		18/61 (30%)
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	125/266 (47%)
		DDHD	746..924	CDD:280937
		LNS2	1072..1203	CDD:197870
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810