Protein Alignment FBXW2 and fbxw2

DIOPT Version :10

• Sequence 1: NP_001362819.1
• Gene: FBXW2 / 26190
• HGNCID: 13608
• Length: 486
• Species: Homo sapiens
• Sequence 2: NP_001018175.1
• Gene: fbxw2 / 553942
• ZFINID: ZDB-GENE-050522-303
• Length: 455
• Species: Danio rerio
• Alignment Length: 455
• Identity: 361/455 - (79%)
• Similarity: 413/455 - (90%)
• Gaps: 1/455 - (0%)

Human    33 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELS 97
            ||:..||.||:::|.:||.|:|.|:|:|||||||||||.|||||||.||.|||||||:||||||:
Zfish     1 MEKVAFEGWLESVSTSFLVLSDQQRNQTLDHLISLSGAAQLRHLSNGLEALLKRDFLRLLPLELA 65

Human    98 FYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRM 162
            ||||:|||||||||||||.|||||||:.||||||:.|::|||:||:|:|||.|||.:||||.|||
Zfish    66 FYLLRWLDPQTLLTCCLVCKQWNKVINGCTEVWQSVCRDLGWRIDESIQDARHWKVIYLKAKLRM 130

Human   163 KQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFD 227
            |||.:.:|||||||||||||||||||:||||||||||||||||||.||||||||||||||.||||
Zfish   131 KQLREEDAFETSSLIGHSARVYALYYRDGLLCTGSDDLSAKLWDVRTGQCVYGIQTHTCATVKFD 195

Human   228 EQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTC 292
            ||||||||||||:||||||:||:.|.||||||||||:|||||||.|||||||||||||:||||||
Zfish   196 EQKLVTGSFDNTIACWEWSTGAKIQQFRGHTGAVFSIDYNDELDTLVSGSADFTVKVWSLSAGTC 260

Human   293 LNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRS 357
            :|||||||||||||.|||.:|:|::||||||||||.||||||:||||||||||||:|||||||||
Zfish   261 VNTLTGHTEWVTKVHLQKSQVESMMHSPGDYILLSVDKYEIKVWPIGREINCKCLRTLSVSEDRS 325

Human   358 ICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIK-TPEIANLALLGFGDIFALLFDNRYLYI 421
            :||||||.|||:||||.|.||:|||||||:|::|||| ..:.::|:||.||::|||||||.:||:
Zfish   326 VCLQPRLQFDGRYIVCCSDLGIYQWDFASFDVIRVIKPQQDPSSLSLLSFGEVFALLFDNHHLYV 390

Human   422 MDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 486
            :|||||..:.|||||.|||||||||||||..||||||||.||.||||||||||||||||||:|:|
Zfish   391 LDLRTEVTVGRWPLPAYRKSKRGSSFLAGVTSWLNGLDGKNDAGLVFATSMPDHSIHLVLWRENG 455

Human   487  486
            Zfish   456  455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW2	NP_001362819.1	F-box_FBXW2	87..126	CDD:438903	33/38 (87%)
		WD40	172..479	CDD:238121	253/307 (82%)
		WD40 repeat	183..217	CDD:293791	31/33 (94%)
		WD40 repeat	220..255	CDD:293791	28/34 (82%)
		WD40 repeat	261..297	CDD:293791	31/35 (89%)
		WD40 repeat	313..351	CDD:293791	31/37 (84%)
		WD40 repeat	359..394	CDD:293791	26/34 (76%)
		WD40 repeat	409..449	CDD:293791	29/39 (74%)
		WD40 repeat	455..477	CDD:293791	19/21 (90%)
fbxw2	NP_001018175.1	F-box_FBXW2	55..94	CDD:438903	33/38 (87%)
		F-box_SF	<77..128	CDD:459239	37/50 (74%)
		WD40	140..448	CDD:238121	253/307 (82%)
		WD40 repeat	188..224	CDD:293791	29/35 (83%)
		WD40 repeat	229..265	CDD:293791	31/35 (89%)
		WD40 repeat	272..319	CDD:293791	37/46 (80%)