DRSC/TRiP Functional Genomics Resources

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Protein Alignment FBXW2 and SCAP

DIOPT Version :10

Sequence 1:NP_001362819.1 Gene:FBXW2 / 26190 HGNCID:13608 Length:486 Species:Homo sapiens
Sequence 2:NP_788277.1 Gene:SCAP / 35529 FlyBaseID:FBgn0033052 Length:1276 Species:Drosophila melanogaster


Alignment Length:489 Identity:90/489 - (18%)
Similarity:159/489 - (32%) Gaps:138/489 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     5 EVVYEVQSAIL----------RHNCGYAMKTGKFFHNLMERKDFETW--LDNISVTFLSLTDLQ- 56
            |..|:....||          :|.....:..|.:..:...:.....|  .....:|.:|.:|:| 
  Fly   862 EAPYKQTEQILEGVPTQIAGHKHRIECLVSDGAYIISCCLKGQIRVWDARSGEQLTSISRSDIQI 926

Human    57 -----KNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCL-- 114
                 ..:||...:::|....|.:..|.:........::|           |..|..||.|..  
  Fly   927 SQQRTDGQTLVRKLAVSPVWCLDYFDNLIAVGCANGRVEL-----------WESPAGLLKCAYQE 980

Human   115 ----------VSKQWNKVISA----CTEVWQTACKNLGWQIDDSVQDALHWKKVYLKA------- 158
                      :....::||.|    ..:.::......|.|||.....|  :::.:::.       
  Fly   981 DAKRNQGITHIHLNGDRVIVARLNGRLDFYRLETYYKGKQIDWGFTSA--YRRTHVRTGSTGSLG 1043

Human   159 -ILRMKQLEDHEAFETSS----------LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC 212
             :|:.::.:...:.:|:.          .:.|...:..:...:.::.|||.|.:.|::.::....
  Fly  1044 LMLQQQRCQQEASQKTTKEEMKITLEGVRLAHQQPITCMQVVNDMVFTGSQDHTLKVYCLNKSDV 1108

Human   213 VYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDIL 273
            .|.:..|    ||..|.                  .|..|         ||.             
  Fly  1109 EYTLHGHCGPVTCLFVD------------------RWQPG---------TGG------------- 1133

Human   274 VSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPI 338
             |||.|..:.||.|..|.|:..:..|..          .|..|..:|...|.|..|: .|.:|  
  Fly  1134 -SGSQDGLLCVWDLFTGACMYNIQAHDG----------AVSCLACAPSYVISLGTDE-RICVW-- 1184

Human   339 GREINCKCLKTLSVSEDRS--ICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANL 401
             .......|.|:::|...|  :.|.|.|      :|.|....|..||..:....|.:|. :.|||
  Fly  1185 -ERFQGNLLTTINISNAYSSLLMLTPSL------LVTSKMGSLIVWDVRTGQPAREVKL-DFANL 1241

Human   402 ALLGFGDIFALLFDNRYLYIMDLRTESLISRWPL 435
            .|.  ..|..|..|:   .:.|...|..:.|:|:
  Fly  1242 QLC--PKIMMLACDS---VVCDYGNEIRVVRFPI 1270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FBXW2NP_001362819.1 F-box_FBXW2 87..126 CDD:438903 9/54 (17%)
WD40 172..479 CDD:238121 59/280 (21%)
WD40 repeat 183..217 CDD:293791 6/33 (18%)
WD40 repeat 220..255 CDD:293791 5/34 (15%)
WD40 repeat 261..297 CDD:293791 9/35 (26%)
WD40 repeat 313..351 CDD:293791 10/37 (27%)
WD40 repeat 359..394 CDD:293791 9/34 (26%)
WD40 repeat 409..449 CDD:293791 7/27 (26%)
WD40 repeat 455..477 CDD:293791
SCAPNP_788277.1 Sterol-sensing 390..543 CDD:463544
WD40 878..1185 CDD:475233 61/374 (16%)
WD40 repeat 887..942 CDD:293791 8/54 (15%)
WD40 repeat 945..983 CDD:293791 8/48 (17%)
WD40 repeat 989..1070 CDD:293791 10/82 (12%)
WD40 repeat 1079..1114 CDD:293791 6/34 (18%)
WD40 repeat 1120..1157 CDD:293791 16/77 (21%)
WD40 repeat 1162..1196 CDD:293791 10/37 (27%)
WD40 repeat 1201..1233 CDD:293791 9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

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