DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GART and Gart

DIOPT Version :9

Sequence 1:	NP_000810.1	Gene:	GART / 2618	HGNCID:	4163	Length:	1010	Species:	Homo sapiens
Sequence 2:	NP_001285698.1	Gene:	Gart / 33986	FlyBaseID:	FBgn0000053	Length:	1353	Species:	Drosophila melanogaster

Alignment Length:	1359	Identity:	499/1359 - (36%)
Similarity:	683/1359 - (50%)	Gaps:	380/1359 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISN---TAISISDHTALAQFC 62
            |:.|||:||||||||.:.|||:||..|.|:...||:.|....||..|   ..:...|..|:|::.
  Fly     1 MSHRVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWS 65

Human    63 KEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAF 127
            ||.:|..||||||.|||.|:...|:|||:.||||..:.||:|:.|::||:||.|||||||::::|
  Fly    66 KENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARYESF 130

Human   128 TKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEEL 192
            |..|:|.:||.||.:|||||||:||||||||:||.:.:|||:||.||:.:..:|.||.|:|:|||
  Fly   131 TDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEEL 195

Human   193 LDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQR 257
            |:|||||.|.|||||:|..|.||||||||..||.||||||||||||.|.:|...|..::..||:|
  Fly   196 LEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLER 260

Human   258 TVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTLDGLLC 322
            .|.|:.:|...|.|:||||:|||::||:||||||||||||.|||||||:|||::|:::...|.|
  Fly   261 AVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKL- 324

Human   323 TSLPV-WLENHTALTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGK-VVTHGGR 385
            ..:|: |....:|:.|::||.|||...|||..|:|.|.|......|||:|.|:...| .:|:|||
  Fly   325 DKIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGR 389

Human   386 VLAVTAIRENLISALEEAKKGLAAIKF--EGAIYRKDVGFRA--IAFLQQPRSLTYKESGVDIAA 446
            ||...|:..:|..|..:|.|...:|.|  .||.||.|:..:|  ||....| .|:||:|||||.|
  Fly   390 VLIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTP-GLSYKDSGVDIDA 453

Human   447 GNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDT 511
            |:.||::|:||::.|.|.|....||||.|||.||...:|:|::|..|.|||.|:.:|.....::.
  Fly   454 GDALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHELYEN 518

Human   512 IGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPD 576
            :|.||.|:..||:|..||||:.||||.:||||.:.:...:|.|:|..|..|.|||:||||||||.
  Fly   519 VGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPS 583

Human   577 MYPPGEYDLAGFAVGAMER---------------------------------------------- 595
            :|.||::|:||:.||.:|:
  Fly   584 LYAPGQHDMAGYCVGIVEQSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRER 648

Human   596 ------------------------DQKLPHLER-------------------------------- 604
                                    .|.||||::
  Fly   649 SPVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDF 713

Human   605 ----------------------------------------------------------------- 604

  Fly   714 GAVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSG 778

Human   605 ----------------------------------------------------------------- 604

  Fly   779 SPVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKD 843

Human   605 ----------------------------------------------------------------- 604

  Fly   844 PILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKEV 908

Human   605 -----------------------------------------------------ITEGDVVVGIAS 616
                                                                 |..|||::|:.|
  Fly   909 HSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLDEIQPGDVLIGLPS 973

Human   617 SGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGH--VKAFA 679
            ||:||||||||..::.:..|.....||  ..|:|||:.||.||:||..:|..:|..|.  :||.|
  Fly   974 SGVHSNGFSLVHAVLKRVGLGLHDKAP--FSDKTLGEELLVPTKIYVKALSTLLSRGKHGIKALA 1036

Human   680 HITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLVVSKE 744
            |||||||.|||||||.:.|.|.|||..:::|.||:||...|::|..|:.||:|||:|.||||:..
  Fly  1037 HITGGGLSENIPRVLRKDLAVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPT 1101

Human   745 QTEQILRDIQQHKEEAWVIGSVVARAE-GSPRVKVKNLIESMQINGSVLKNGSLTNHFSFEKKKA 808
            :.|.:|::: ::.:.|.|:|.||||.: ...:|.|:|...|:.....:|           .:::.
  Fly  1102 EVEDVLKEL-RYPQRAAVVGEVVARKDPKKSQVVVQNFEASLARTQKML-----------SQRRK 1154

Human   809 RVAVLISGTGSNLQALIDSTREPNSSAQIDI--VISNKAAVAGLDKAERAGIPTRVINHKLYKNR 871
            ||||||||||||||||||:||:.......|:  |||||..|.||.:|.:||||:.||:||.:.:|
  Fly  1155 RVAVLISGTGSNLQALIDATRDSAQGIHADVVLVISNKTGVLGLQRATQAGIPSLVISHKDFASR 1219

Human   872 VEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGV 936
            ..:|:.:...|:...:|::|||||||:||.|||::|.|:::||||||||.:.|.:..:||||.|.
  Fly  1220 EVYDAELTRNLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEAGE 1284

Human   937 TVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGT 995
            ..:|||||||.|.||.|.||:|.|||:...|...:|::|:..|||..||.||.::.:||
  Fly  1285 KESGCTVHFVDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRALAMLVNGT 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GART	NP_000810.1	purD	4..426	CDD:273315	225/430 (52%)
		GARS_N	4..104	CDD:280931	50/102 (49%)
		GARS_A	105..298	CDD:279419	119/192 (62%)
		GARS_C	334..424	CDD:280930	38/92 (41%)
		AIRS	434..809		171/727 (24%)
		PRK05385	435..766	CDD:235439	162/682 (24%)
		PurM	469..767	CDD:100032	144/649 (22%)
		FMT_core_GART	809..991	CDD:187714	97/183 (53%)
		GART	810..1010		98/188 (52%)
		5'-phosphoribosylglycinamide binding	818..820		1/1 (100%)
		10-formyltetrahydrofolate binding	896..899		2/2 (100%)
		10-formyltetrahydrofolate binding	947..951		1/3 (33%)
		5'-phosphoribosylglycinamide binding	977..980		0/2 (0%)
Gart	NP_001285698.1	PRK00885	4..433	CDD:234856	225/429 (52%)
		GARS_N	4..107	CDD:280931	50/102 (49%)
		GARS_A	108..301	CDD:279419	119/192 (62%)
		GARS_C	337..430	CDD:280930	38/92 (41%)
		PRK05385	442..752	CDD:235439	85/309 (28%)
		PurM	485..752	CDD:100032	60/266 (23%)
		PRK05385	836..1122	CDD:235439	77/288 (27%)
		PurM	840..1123	CDD:100032	77/285 (27%)
		FMT_core_GART	1155..1339	CDD:187714	97/183 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160074
Domainoid	1	1.000	249	1.000	Domainoid score	I2137
eggNOG	1	0.900	-	-		E1_COG0151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H637
Inparanoid	1	1.050	682	1.000	Inparanoid score	I714
Isobase	1	0.950	-	0	Normalized mean entropy	S947
OMA	1	1.010	-	-		QHG55216
OrthoDB	1	1.010	-	-		D105366at2759
OrthoFinder	1	1.000	-	-		FOG0003222
OrthoInspector	1	1.000	-	-		oto89166
orthoMCL	1	0.900	-	-		OOG6_100441
Panther	1	1.100	-	-	LDO	PTHR10520
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1035
SonicParanoid	1	1.000	-	-		X2637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750