DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INTS1 and IntS1

DIOPT Version :10

Sequence 1:XP_011513562.1 Gene:INTS1 / 26173 HGNCID:24555 Length:2200 Species:Homo sapiens
Sequence 2:NP_611875.1 Gene:IntS1 / 37840 FlyBaseID:FBgn0034964 Length:2053 Species:Drosophila melanogaster


Alignment Length:2297 Identity:716/2297 - (31%)
Similarity:1131/2297 - (49%) Gaps:353/2297 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRDAAAAL 65
            |:|.|.:...| |....|.|    |:..||| |...::||:....:|...|   |:|||:|:.||
  Fly     1 MDRGKGSGSNR-SQKKVPLG----GELFALG-KSVRDDSKSKILPIKGMSS---SDRKREASTAL 56

Human    66 SSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIK--EPSVVPIEVLPTVLLDEIEA 128
            :|:|      ||.:          |.|.:|...:..:.|...:  |...|..: |.||:  |...
  Fly    57 ASSS------KRFR----------GNLKDAGAPDMSSGSSQCETWEQFAVDCD-LDTVV--ETIY 102

Human   129 AELEGNDDRIEG-VLCGAVKQLKV--TRAKPDSTLYLSLMYLAKIKPNIFATEGVIEALCSLLRR 190
            |.||.||....| ::||.:||...  :|:|.|:...|:|:|:||::|:||.|:.|..||.|.|||
  Fly   103 AALEQNDSETVGRLVCGVIKQTTTSSSRSKVDNIALLALIYVAKVQPSIFCTDIVACALLSFLRR 167

Human   191 DASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCKTFVDNIQT 255
            :|  |.|.:.|:.:.:|..|||...:.|...|||:.:::||:|::.||.|.|:..|...|.||..
  Fly   168 EA--NVKMRYNTNLHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICA 230

Human   256 AFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDS---QTELLIA-----EEKLSPEQEG 312
            ||.||.|..|:|    ...|:..|.:|.:...|:|.::||   .|:.|.|     |.:..|:...
  Fly   231 AFKTRTPHISLL----RWDVSSSLPSGQAHRDSMTVDDDSGDNSTQSLDASPLNTESEPIPDAMC 291

Human   313 QLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGYKEVRLLAVQKLEMWLQN 377
            ....|:.:..  |:::|.|.:|||||:||..||.:||.|:.|.:|.|..|||.|::.:||:|:.|
  Fly   292 TTKSRFSDAV--VQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWIHN 354

Human   378 PKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKVLLNHFMLCIRELLSAHKDNLGTTI 442
            .||.:.||.||..:|.|.....::|.:|:..|:|:|||.|.|:||:|.|::|::....:.|.|.:
  Fly   355 GKLVKFAQQLLSYICFNIKGRNTQDNEVLLVLVKMRLKTKPLINHYMSCLKEMIFLQPEILSTVM 419

Human   443 KLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTK 507
            |||:.||||:.||||||.:|.|..|.|::.:...||.::|:.|..:||.||..|..|||:::..:
  Fly   420 KLVVQNELSNTRNPNNMGMLATMFQTSADQSAATLAEIYQEFLLQRDDCLRTLRVFLRELVRMLR 484

Human   508 HEINFQAFCLGLMQERKE--PQYLEMEFKERFVVHITDVLAVSMMLGITAQVKEAGIA--WDKGE 568
            .::|...||...:.||::  ||....|||||....:.|::.:.|.|..|.|.:||.::  .::..
  Fly   485 FDVNLVKFCKTFLSEREDLTPQIEMFEFKERIFNSMVDIVCLCMFLSATPQAREASLSLKTNRDT 549

Human   569 KRNLEVLRSFQNQIAAIQRDAVWWLHTVVPSISKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPE 633
            |.|..:|:.: ||::.||.|.|.|::..||::.|:...:|...|||:|..:.||.|.:.|.||.|
  Fly   550 KNNHALLKLY-NQMSQIQLDTVSWMYETVPTLFKIPAAEYHQALHKLLLLDSPEQYSRCDQWPSE 613

Human   634 SDRNFFLRLCSEVPILEDTLMRILVIGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGR 698
            .:|...||:.||.||.|:||:||::||:::::|...|:..::...::||.:.::|.::..::..:
  Fly   614 PERGAILRIISETPIHEETLLRIILIGITKDIPFSIANTFDVLLLVIKRVSGMKATNIPAVQANK 678

Human   699 TQLIDAVLNLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTL 763
            ..:||.:.::..|||||||:||..|:||.|||...|||||.:||:::|.||.:.|...|:.|||:
  Fly   679 FDIIDFLFSMSEYHHPENIRLPAEYEPPKLAIIAFYWKAWLILLMISAHNPSSFGAFCWDHYPTM 743

Human   764 KMLMEMVMTNNYSYPPCTLTDEETRTEMLNRELQTAQREKQEILAFEGHLAA-ASTKQTITESSS 827
            ||:||:.:||.::....|           ..|||....|:..||.||.:||| .|....|||.::
  Fly   744 KMMMEICITNQFNNSSAT-----------KDELQIITMERDHILQFETYLAAQTSPHAVITEETA 797

Human   828 LLLSQLTSLDPQGPPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLA 892
            :|::||..:||.|.||:.|..:|||:|.|||:.:||||.||.|.||.||.|||||.::||||||:
  Fly   798 ILITQLMLMDPMGTPRKVPSMVLDQLKFLNQTYKLGHLFCRCRKPDLLLDIIQRQGTTQSMPWLS 862

Human   893 DLVQSSEGSLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDL 957
            ||||:|||....|||||||||||.:|   ....||:                .:..:|:..|::|
  Fly   863 DLVQNSEGDFSHLPVQCLCEFLLFNA---HIINEEN----------------SRDAELVNFLRNL 908

Human   958 LLGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDTDV 1022
            :.......|..||:|||..|||.|:...|||.|:.||.::....                ||.: 
  Fly   909 IFDGNLSHQIVCELLDYIFRRLSSTVKQSRVAALSGLKIIFRHS----------------GDFE- 956

Human  1023 LQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHT---PVEEQAQHSD 1084
               .:|||:.|.::|.|..|:......|:.|..:|..|:.|.||:.:::.||   ||.|...|  
  Fly   957 ---NEWLLKSLQQIPHFYEVKPFIIPQLRAACQVENCPELIMAYIQFITAHTLNDPVNEMLDH-- 1016

Human  1085 LALDVARLVVERSTIMSHLFSKLS-----PSAASDAVLSALLSIFSRYVRRMRQSKEGEEVYSWS 1144
             .:|:|:|:|||||:..|:.....     |.......|..|..:|:.|:.::|   |..|.|.|:
  Fly  1017 -VIDMAQLIVERSTMFQHIIISQEDYDYVPDENRIQTLKCLFVMFNNYIIKLR---EYHEPYEWT 1077

Human  1145 ESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEKPLPTAFLVDTS 1209
            |..|.:.:::..|....:||.::||.:||||..  .::..|...:||.|||..:|.|.|||....
  Fly  1078 EYPDLLMVQFDDGVQLPLHINIIHAFIILLTYS--NSNMPESIPILDYWFPPGRPAPVAFLPSMP 1140

Human  1210 EEAL-LLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSMSKLLQFLDQAVAHDP 1273
            :|.: ||||||||:||||.|.||::|||.||.|.|::||||:||.||:||||||..||.||....
  Fly  1141 QEQVQLLPDWLKLKMIRSSVDRLIEAALNDLTPDQIVLFVQNFGTPVNSMSKLLAMLDTAVLEQF 1205

Human  1274 QTLEQNIMDKNYMAHLVEVQHERGASGGQ-TFHSLLTASLPPRRDSTEAPKPKSSPEQPIGQGRI 1337
            ..::..|::|.|:|.|:|:|..|||..|. |..:|...|           ..::.|:.|    :|
  Fly  1206 DLVKNAILNKAYLAQLIEIQQARGAKNGHYTVQALDLHS-----------HSQTVPDLP----KI 1255

Human  1338 RVGTQLRV------LGPEDDLAGMFL------QIFPLSPDPRWQSSSPRPVALALQQALGQELAR 1390
            .|..|..|      ....||....||      |.....||   |.:..|....:|.|.|...||.
  Fly  1256 SVVIQEAVEIDDYDSSDSDDRPTNFLATKEVAQTILTQPD---QLTESRSDCRSLIQKLLDMLAS 1317

Human  1391 VVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQLCQYQRCVPQDTGFSSL 1455
            ......:|......||..         |.::.||.|     ||..||            |.||.:
  Fly  1318 PNSNRADVVNAITEVLAV---------GCSVTMSRH-----ACTFLR------------TFFSCM 1356

Human  1456 FLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVRGGLLRLAEALAFRQDLEVVSST 1520
            .......:|:         ..|:..|.|..      ...:|  ..||:.:|  .:.:.|..:...
  Fly  1357 LHSDKYHILE---------NALQKNLSMFK------HTFAD--SSLLQKSE--LYHESLVFMLRN 1402

Human  1521 VRAVIATLRSGEQCSVEPDLIS--KVLQGLIEVRSPHLEELLTAFFSATADAASPFPACKPVVVV 1583
            .|.:.|     :|......|::  ::::.:::            .|..|.|:       |.|...
  Fly  1403 SREIYA-----QQFKANTALVARKRIVRAIVQ------------SFDQTKDS-------KTVAKS 1443

Human  1584 SSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLLVDWLEMLDPEVVSSCPDLQL---RLLFSRR 1645
            .|..|..                        :||.:|||..:|||:||:    ||   |.|||: 
  Fly  1444 KSDQLFH------------------------NGLFIDWLSEMDPEIVST----QLMKERFLFSK- 1479

Human  1646 KGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIRVLLGKSREQRFDPSASLDFLWACIHVPRIWQG 1710
                  ....||.|||:|..||::|.|:.: |...|.|:..:.:|.:..|::..|....|::|:|
  Fly  1480 ------SCSEFRFYLLSLINHQTNWDTIER-IAEYLFKNFHEDYDYATVLNYFEALTTNPKLWKG 1537

Human  1711 RDQRTPQKRREELVLRVQGPELISLVELI----LAEAETRSQDGDTAACSLIQARLPLLLSCCCG 1771
            ||:...:..|.:....::..||......|    |:|.:..|::.|...||    |:.||......
  Fly  1538 RDKYMSKNVRPDAFFMLRTSELEPFSHFILHEGLSEVKLDSKNYDFKLCS----RMNLLFKLTEK 1598

Human  1772 DDESVRKVTEHLSGCIQQWGDSVLGRRCRDLLLQLYLQRPELRVPVPEVLLHSEGAASSSV---- 1832
            ..:.:.||.||:.      ..||.......:|.|:|:..|.::...|       |......    
  Fly  1599 RRDLMVKVMEHVE------KSSVSDYLKLQVLQQMYIMYPRIKFLKP-------GKTGEQAYKLQ 1650

Human  1833 ----CKLDGLIHRFITLLADTSDSRALENRGADASMACRKLAVAHPLLLLRHLPMIAALLHGRTH 1893
                |:.|.:.:..||.|......:..|....|..:..||||.:||||.||.|.::::::.||..
  Fly  1651 NLKGCQADKVSNNLITCLGSLVGKKDFETLSTDTELLLRKLAASHPLLFLRQLGVLSSIMQGRAQ 1715

Human  1894 LNFQEFRQQNHLSCFLHVLGLLELLQPHVF----RSEHQGALWDCLLSFIRLLLNYRKSSRHLAA 1954
            |:.:..|:::|...|:.:|..||||||.:|    ::|.|..| .|..:|.:    :..:.:....
  Fly  1716 LSMKALREEHHFHRFVQILRTLELLQPTIFEEAYKNEIQNTL-SCYFNFFK----HHSNVKEACQ 1775

Human  1955 FINKFVQFIHKYITYNAPAAISFLQKHADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLD 2019
            .:|||||.:..||.||..:|:.|::::...|.:|:...:.|..|:.|:..::|......:...||
  Fly  1776 MLNKFVQMLQAYINYNPSSALLFIEQYVGILKELAAKYTSLGKLQVLVQAVALLQHKSHSATELD 1840

Human  2020 EEG-----------------------------------EEESSAGSLPLVSVSLFTPLTAAEMAP 2049
            :|.                                   :..||.|.|.::::..::.....:::|
  Fly  1841 DEEVKYEYDLDEHFDVKPSASKPVVTEDPIEVNPQTPIDPSSSRGPLSVLTLGSYSRSNYTDISP 1905

Human  2050 Y----MKRLSRGQTVEGESGPASPTPDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEECCR 2110
            :    :|.:.:..|.:...||          :.:::.::.:|...::.....|..|:.|.....|
  Fly  1906 HFLDLVKIIKQSNTEDVVLGP----------MQELECLTSKRFVFINELFERLLNLIFSPSAQIR 1960

Human  2111 NLAFSLALRSMQNSP---SIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVLLHRA 2172
            ::||.:.:|.::::|   .|....|..::.||..::..|..||:.||||.::|.||||..:|..|
  Fly  1961 SIAFIILIRHLKHNPGNSDINLCTLNAYIQCLRDENSSVAATAIDNLPEMSVLLQEHAIDILTVA 2025

Human  2173 FLVGMYGQMDPSAQISEALRIL 2194
            |.:|:...::...||.:.|:.|
  Fly  2026 FSLGLKSCLNTGHQIRKVLQTL 2047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INTS1XP_011513562.1 DUF3677 350..430 CDD:463578 33/79 (42%)
IntS1NP_611875.1 DUF3677 327..407 CDD:463578 33/79 (42%)

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