DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INTS1 and ints-1

DIOPT Version :10

Sequence 1:XP_011513562.1 Gene:INTS1 / 26173 HGNCID:24555 Length:2200 Species:Homo sapiens
Sequence 2:NP_491739.2 Gene:ints-1 / 182280 WormBaseID:WBGene00015499 Length:1884 Species:Caenorhabditis elegans


Alignment Length:2257 Identity:425/2257 - (18%)
Similarity:755/2257 - (33%) Gaps:697/2257 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    44 TLLKPAPSGLPSERKRDAAAALSSASALTG-----------LTKRPKLSSTPPLSALGRLAEAAV 97
            |::||     ...:|......|.:.|..||           |..|.| :..||...|...|..::
 Worm    12 TIMKP-----EDMKKAKLNHKLPTTSGGTGGPSTSGGVKAKLDFRSK-TCIPPKPTLSNSANPSL 70

Human    98 AEKRAISPSIKEP-----SVVPIEVLPTVLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPD 157
            .....:.|::.:.     ..:.:.:  ......::.|.|.|:..:|..:...|:|...|...   
 Worm    71 QSSHLVRPNLDDQWKDFGDTINLNI--ETFQKSVQEAILAGHFTKIAKMFVAALKSFFVGEK--- 130

Human   158 STLYLSLMYLAKIKPNIFATEGVIEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENW 222
                      .|::..|..|  :.|.:            |..|:.|..:.....|:.......::
 Worm   131 ----------LKVELRIMGT--IAETV------------KNHGDKLNQIPLHRALLFVICNSRSY 171

Human   223 P----EIFVKV------------------YIEDSLGERI---------WVDSPHCKTFVDNIQTA 256
            |    |:|:.:                  ::.||:|..:         |::.......|..|...
 Worm   172 PDNILELFISIITSLARQQPILDKCYLTAFLHDSIGMSVGLGTMNRCSWIEKECSAELVKMILDP 236

Human   257 FNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTELL-IAEEKLSPEQEGQLMPR--- 317
            |.|..|..::..|.:.                   |..:.:|.| ...||:...:|..  ||   
 Worm   237 FETVYPFPAMYAQCQV-------------------ENFAISEFLSFFSEKVGKSREKS--PRSNL 280

Human   318 YEELAESVEEYV---LDMLRDQLNRRQPIDNVSRNLLRLLTSTCGYKEVRLLAVQKLEMWLQNPK 379
            :::..:...|::   .|.:|.::        :.:.|.|.|...|||:.:||....:||:|:...|
 Worm   281 HQKQLDVFLEFLKPWFDTIRGEV--------LPKPLFRALCLLCGYEHIRLFIANRLEIWITLQK 337

Human   380 LTRPAQDLLMSVCMNCNTHGSE-DMDVISHLIKI---RLKPKVLLNHFMLCIRELLSAHKDNLGT 440
            ..|...:||:.:..|.|....| |.::|..|:|:   .:|.:.::..|...|:.:....: |:..
 Worm   338 FHREISELLLVIGSNINAENHELDKEIIDILLKLNTKNMKTRTVVGPFTQAIKTICEVSR-NVEI 401

Human   441 TIKLVIFNELSSARN--PNNMQVLYTALQHSSELAPKFLAMVF-QDLLTNKDDYLRASRALLREI 502
            .:..:..||...|:|  |.|:|.:|..||:....|.|.||::. ::|...|::.::..||.:||:
 Worm   402 VLDSLFINETGPAQNRSPTNLQTIYMILQNQPTEATKALAVIISKELFKEKENCVKMLRAFMREL 466

Human   503 IKQTKH----EINFQAFCLGL---MQERKEPQYLEMEFKERFVVHITDVLA------VSMMLGI- 553
            |:...|    :..|..|...|   :|.|.||        :..:.:..|::|      :|.:|.. 
 Worm   467 IRGFYHSKSGDFPFSVFAETLFNKVQRRGEP--------DEILSYAVDLIAQLPLATISSLLTTR 523

Human   554 -------------TAQVK----EAGIAWDKGE----------------KRNL-----EVLRSFQN 580
                         |..|.    ||.:|..|.|                .|||     ..:|||..
 Worm   524 ENAFSIKFSVPTGTGDVPLIPVEARLARQKFECEFISYCEKVIEQLLKSRNLFFDEQVFIRSFSI 588

Human   581 QI-AAIQRDAVWWLHTVVPSISKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCS 644
            .: ...|||....:.....:.|:::     :|:.  :|.|...:            .|..|.:|.
 Worm   589 LLYLETQRDVYTGIEMAAVTDSEIS-----NCIR--IFGECGVS------------ENMLLMICR 634

Human   645 EVPILEDTLMRILVIGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQ---LIDAVL 706
            |    |.|           :||  ....::|...|.:|||...........:..|:   |||:.|
 Worm   635 E----ETT-----------QLP--QKSQIDLISALTQRAALFHPKITTNPLIRITEPFKLIDSYL 682

Human   707 NLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGL--AAWEEYPTLKMLMEM 769
            .:..:...|    .|...|| :.....||.||..:::..|...|.|..  ..:.|||.|:.|:..
 Worm   683 KMTIFPRKE----APRLDPP-ICNRKFYWTAWTTIILWIAAGTEIISFFEEIYSEYPILRYLIHC 742

Human   770 VMTNNYSYPPCTLTDEETRTEMLNRELQTA-QREKQEILAFEGHLAAASTKQTITESSSLLLSQL 833
            ::...:.:|   |..|.....|:|.|...| ..|.:.|..:|.::..|                :
 Worm   743 ILCQKFEFP---LEFEGKSVAMMNDEEAVAVDVETRVIEMYEKNMKRA----------------V 788

Human   834 TSLDPQGPPR---RPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLV 895
            .::..:.|.|   |.|| :||.:.......:|.....|..:|..|..:|....|..|:..:.:::
 Worm   789 PAMSMEFPNRNSFRAPP-LLDDIHLFADKFKLASRFSRCTSPPLLSRLISNVGSENSLFAVREML 852

Human   896 QSSEGSLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLLLG 960
            .|...:..:|..:|:...|::  ..|.....:.|:..:...||..||.:...:.:....||.|  
 Worm   853 SSDSTTAKILTAECIFHALMY--YFDNQRIRDSDQNSTVVVKALIRQAEVNLKSIEPIEQDFL-- 913

Human   961 PKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDTDVLQG 1025
                       |..|:..|.||.:::|..|:...|.:.            |..|||.. .|::: 
 Worm   914 -----------LHSFISSLASSNISTRSAAVNTCSRLF------------PSSEEDKA-FDLVK- 953

Human  1026 YQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYL---SQHTPVEEQAQHS---D 1084
                   |..:|.|::.:......:..|:.:|:|....::||.:|   |.:|..:....|:   .
 Worm   954 -------LSNVPRFNARKLKYMEIIASAVLVESDSHLSNSYLQFLTINSMNTSDDHTVAHAICQT 1011

Human  1085 LALDVARLVVE---------RSTIMSHLFSKLS--------------PSAASDAVLSALLSIFSR 1126
            |::|..:|...         .:.:.:|....::              ..|.|:.|.||::.:.|:
 Worm  1012 LSIDCIQLHTSLCEYFLQYVDTCLKNHQIKNITSLDTSLTCIEFGNQKIALSNEVPSAIVKLLSK 1076

Human  1127 YVRRMRQSKEGEEVYSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLD 1191
            |                    |.:       :||...|                 .|..|:.||:
 Worm  1077 Y--------------------DNL-------QTAEKGI-----------------SDPSFEGLLE 1097

Human  1192 IWFPEEKPLPTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVS 1256
            : |.....:|.....:|......|...::..|::|...|:|||||..|....    .|.| |.||
 Worm  1098 L-FLSPNAIPNIIDRETGASNQFLSLQMRKEMLKSVEQRVVDAALIGLSEHD----AQEF-ILVS 1156

Human  1257 SMSKLLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHER--------------GASGGQTFHSL 1307
            .|||             :|.|:.|.....|. |..:.|:.              |...|:|    
 Worm  1157 RMSK-------------ETAEKVIKMAENMP-LDRIDHQSLSNMYLLIRGYRMIGVQSGET---- 1203

Human  1308 LTASLPPRRDSTEAPKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSS 1372
            |...:..:.|:.:|...|..|.:     .:.|.|        :|:...||               
 Worm  1204 LINRIKSQMDNLDAFIAKEEPME-----IVEVNT--------NDMPTEFL--------------- 1240

Human  1373 PRPVALALQQALGQELARVVQGS-----------PEVPGITVRVLQALA--------TLLSSPHG 1418
                         .|..|:.:.|           |.|....::...:||        ::.|.|  
 Worm  1241 -------------IESMRIAESSSFSNQKEEKMDPNVIATWLKTNCSLAASTKNKETSIFSLP-- 1290

Human  1419 GALVMSM--HRSHFLACPLLRQLCQYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQL 1481
            .|.:.|.  ..:..:|| |.......:..:..:|.|.:|.:.:                      
 Worm  1291 AAFIQSAMNDETSSIAC-LAHIEANLKFFLSFETAFQTLIVII---------------------- 1332

Human  1482 RMLASQASAGRRLSDVRGGLLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQ 1546
                  .||..:.:.||..|..||..|                   |:|    ...|:.::.:||
 Worm  1333 ------DSAANKFNFVRNRLENLATRL-------------------LKS----VTPPESVAGILQ 1368

Human  1547 GLIEVRSPHLEELLTAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRL 1611
                   .|          |.....|...:.||..:..|...:..:.:...|..|:...::..| 
 Worm  1369 -------KH----------AANSIKSVQKSIKPTPIKISTFAEFSKSIKNLKSSANSSEIKEKR- 1415

Human  1612 GPSSGLLVDWLEMLDPEVVSSCPDLQLRLLFSRRKGK--GQAQVPSFRPYLLTLFTHQSSWPTLH 1674
                  |||                :..:.|...||:  ....:..|...:.::::.:::..|..
 Worm  1416 ------LVD----------------EFMIQFVEDKGEVIDSDDILIFIASIQSVYSGENAEITAE 1458

Human  1675 QCI---------RVLLGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTP------------QK 1718
            :|:         :|:.....|:.:....|       |.|.|:.....::.|            ..
 Worm  1459 RCLSNRWSAQLRKVVSSTILEKYYTQLCS-------IFVFRLISAYCKKYPLASYSEMFTLREPG 1516

Human  1719 RREELVLRVQGPELISL-------------VELILAEAETRSQDG-DT----------AACS--- 1756
            .:||.||..:..:...|             :::|...|...||.| ||          .||:   
 Worm  1517 NKEEFVLNRRAFDNCILYFCDVAADSHEYDLQIINLIAGLESQGGTDTGFYFGRALLETACANPK 1581

Human  1757 ------------LIQARLPLLLSCCCGDDESVRKVT--EHLSGCIQQWGDSVLGRRCRDLL---- 1803
                        |::.||| .||...|...|:|.:|  |....||         |||..::    
 Worm  1582 SVTRITAKRLLELLRDRLP-YLSYRNGISSSIRVLTNVESRESCI---------RRCEQIVDRIV 1636

Human  1804 -----LQLYLQR---PELRVPVPEVLLHSEGAASSSVCKLDGLIH--------------RFITL- 1845
                 |::.|..   .|.|:....:...||.||.:|  |..|...              |||:. 
 Worm  1637 EMPIDLKMALSEDICEEERIKKDRIREKSEEAAENS--KFGGKRSAGDRRGGGPPPKKGRFISAK 1699

Human  1846 -----LADTSDSRAL-------ENRGADASMACRK---LAVAHPLLLLRHLPMIAALLHGRTHLN 1895
                 |...:|..::       :....|.|.|..:   |...||..|....|::|..:.....:|
 Worm  1700 DLPVPLGQQNDEDSINAEDVPVKREWIDTSHAMTRFVSLLREHPNFLKMKFPVLANYVSRVNAMN 1764

Human  1896 FQEFRQQNHLSCFLHVLGLLELLQPHVFRSEHQG---ALWDCLLSFIRLLLNYRKSSRHLAAFIN 1957
            .:|..::|.:.....:|..:.:|.||:...|...   ||.:||..:.:.:.......:...||..
 Worm  1765 RKELAEENRVGKIELILQSVIVLCPHMAPDEMSSVDTALSNCLEFYEKHIDEGGFGIKEQTAFAE 1829

Human  1958 KFVQFIHKYITYNAPAAISFLQKHADPL-------HDLSFDNSDLVM 1997
            ..::...:|:.::...|.|||:.:...:       ||..  |.|||:
 Worm  1830 LTIRACAEYLNHSFVEARSFLRDNRQLIDRVCKRCHDRY--NVDLVL 1874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INTS1XP_011513562.1 DUF3677 350..430 CDD:463578 25/83 (30%)
ints-1NP_491739.2 DUF3677 308..392 CDD:463578 25/83 (30%)

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