Protein Alignment GARS1 and Gars1

DIOPT Version :10

• Sequence 1: NP_002038.2
• Gene: GARS1 / 2617
• HGNCID: 4162
• Length: 739
• Species: Homo sapiens
• Sequence 2: NP_851009.2
• Gene: Gars1 / 353172
• MGIID: 2449057
• Length: 729
• Species: Mus musculus
• Alignment Length: 739
• Identity: 675/739 - (91%)
• Similarity: 706/739 - (95%)
• Gaps: 10/739 - (1%)

Human     1 MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCPPISLPAAASRSSMDGAGAEEVLA 65
            ||...|.|||..||||.||.|||::|..:  .:|.|||.:.|      ||||||||  .|||:||
Mouse     1 MPCLLPSLLRATRAALPLLSPPRVVAASA--SQRLLSAPAQP------AASRSSMD--SAEELLA 55

Human    66 PLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVDRAKMEDTLKR 130
            |||||||||||.|||||||||||||||:|||||||||||||||||||||||||||||||||||||
Mouse    56 PLRLAVRQQGDFVRKLKEDKAPQVDVDRAVAELKARKRVLEAKELALQPKDDIVDRAKMEDTLKR 120

Human   131 RFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLTPEPVLKTSGHV 195
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||
Mouse   121 RFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQAWRQHFIQEEQILEIDCTMLTPEPVLKTSGHV 185

Human   196 DKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLAQLDNYGQQELADLFVN 260
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
Mouse   186 DKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSAEKKSEMESVLAQLDNYGQQELADLFVN 250

Human   261 YNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQ 325
            ||||||.|||||||||.|||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   251 YNVKSPTTGNDLSPPVPFNLMFQTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQ 315

Human   326 IGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQSARKM 390
            ||||||||||||||||||||||||||||||||:||||||||:||||.||||||||||:|||||||
Mouse   316 IGNSFRNEISPRSGLIRVREFTMAEIEHFVDPTEKDHPKFQSVADLCLYLYSAKAQVTGQSARKM 380

Human   391 RLGDAVEQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGW 455
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   381 RLGDAVEQGVINNSVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGW 445

Human   456 IEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLA 520
            ||||||||||||||||||||||||||||||||||||||||||||:|||:|||||||||||:|||:
Mouse   446 IEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPNKGAVGKAYKKDAKLVLEYLS 510

Human   521 ICDECYITEMEMLLNEKGEFTIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIM 585
            .||||||:|||:||:||||||||||||||||||||::||||||||:||||||:||||||||||||
Mouse   511 ACDECYISEMELLLSEKGEFTIETEGKTFQLTKDMVSVKRFQKTLHVEEVVPSVIEPSFGLGRIM 575

Human   586 YTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDS 650
            ||:.|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
Mouse   576 YTILEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRNGVSHKVDDS 640

Human   651 SGSIGRRYARTDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNIT 715
            |||||||||||||||||||:||||||||||||||||||||||||||||:||||::|:||||||||
Mouse   641 SGSIGRRYARTDEIGVAFGITIDFDTVNKTPHTATLRDRDSMRQIRAEVSELPNVVRDLANGNIT 705

Human   716 WADVEARYPLFEGQETGKKETIEE 739
            |||||||||||||||||||||:||
Mouse   706 WADVEARYPLFEGQETGKKETVEE 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GARS1	NP_002038.2	PLN02734	61..724	CDD:178335	629/662 (95%)
Gars1	NP_851009.2	PLN02734	46..714	CDD:178335	633/669 (95%)