Protein Alignment GARS1 and gars1

DIOPT Version :10

• Sequence 1: NP_002038.2
• Gene: GARS1 / 2617
• HGNCID: 4162
• Length: 739
• Species: Homo sapiens
• Sequence 2: NP_001373382.1
• Gene: gars1 / 337230
• ZFINID: ZDB-GENE-030131-9174
• Length: 749
• Species: Danio rerio
• Alignment Length: 743
• Identity: 612/743 - (82%)
• Similarity: 663/743 - (89%)
• Gaps: 24/743 - (3%)

Human     4 PR----PVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCPPISLPA---AASRSSMDGAGAE 61
            ||    ||.|.|:.       |.|:|         ||||..|......|   .....:|||: .|
Zfish    24 PRVRTSPVHLCGSS-------PTRVL---------SLSAHLCKKKKRSAWLEMTEGQNMDGS-IE 71

Human    62 EVLAPLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVDRAKMED 126
            |:||||||||::||||||:||.:.||.|||.|||||||||||.||||||:||||||||||.||||
Zfish    72 EILAPLRLAVKEQGDLVRQLKAENAPDVDVSKAVAELKARKRFLEAKELSLQPKDDIVDRTKMED 136

Human   127 TLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLTPEPVLKT 191
            |||||||||||||||||||||||||||||||||||:|.|||||||||||||||||||||||||||
Zfish   137 TLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNILQVWRQHFIQEEQILEIDCTMLTPEPVLKT 201

Human   192 SGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLAQLDNYGQQELAD 256
            |||||||||:||||||||||||||||||||||||||||||..|||:||::|:.|:|||.||||||
Zfish   202 SGHVDKFADYMVKDVKNGECFRADHLLKAHLQKLMSDKKCPAEKKAEMDNVITQMDNYTQQELAD 266

Human   257 LFVNYNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPF 321
            |||.||||||.|||||:||:||||||:|.|||||||.||||||||||||||||||||||||||||
Zfish   267 LFVQYNVKSPSTGNDLTPPISFNLMFQTSIGPGGNMQGYLRPETAQGIFLNFKRLLEFNQGKLPF 331

Human   322 AAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQS 386
            ||||||||||||||||||||||||||||||||||||:||.|.||.|||||.:.|||:|||.||||
Zfish   332 AAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPNEKVHFKFSNVADLDIMLYSSKAQTSGQS 396

Human   387 ARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKT 451
            |:.||||||||||||||:|||||||||||||.|||::.|||||||||:||||||||||||||:||
Zfish   397 AQIMRLGDAVEQGVINNSVLGYFIGRIYLYLVKVGVAKDKLRFRQHMDNEMAHYACDCWDAETKT 461

Human   452 SYGWIEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVM 516
            ||||||||||||||||||.||||||||||||||||||||.||||||||:|||||||||||||..|
Zfish   462 SYGWIEIVGCADRSCYDLLCHARATKVPLVAEKPLKEPKVVNVVQFEPNKGAIGKAYKKDAKFAM 526

Human   517 EYLAICDECYITEMEMLLNEKGEFTIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGL 581
            |||||||||||||.|.||||.||||||||||||:|||||:|:|||||||:||||||||||||||:
Zfish   527 EYLAICDECYITEQEKLLNENGEFTIETEGKTFKLTKDMVNIKRFQKTLHVEEVVPNVIEPSFGI 591

Human   582 GRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHK 646
            |||||::|||||.:||||||||:|||||.|||:|||||||||||||||||:||||||||:|||||
Zfish   592 GRIMYSIFEHTFRIREGDEQRTYFSFPATVAPYKCSVLPLSQNQEFMPFVRELSEALTRNGVSHK 656

Human   647 VDDSSGSIGRRYARTDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLAN 711
            |||||||||||||||||||||||:|||||||||.||||||||||||||||||:.|||.|::||||
Zfish   657 VDDSSGSIGRRYARTDEIGVAFGITIDFDTVNKNPHTATLRDRDSMRQIRAEVGELPEIIRDLAN 721

Human   712 GNITWADVEARYPLFEGQETGKKETIEE 739
            |.||||:||::||:||||||.||||:||
Zfish   722 GAITWAEVESKYPIFEGQETSKKETVEE 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GARS1	NP_002038.2	PLN02734	61..724	CDD:178335	580/662 (88%)
gars1	NP_001373382.1	PLN02734	66..734	CDD:178335	583/668 (87%)