Protein Alignment GARS1 and grs1

DIOPT Version :10

• Sequence 1: NP_002038.2
• Gene: GARS1 / 2617
• HGNCID: 4162
• Length: 739
• Species: Homo sapiens
• Sequence 2: NP_593935.1
• Gene: grs1 / 2543181
• PomBaseID: SPAC3F10.03
• Length: 652
• Species: Schizosaccharomyces pombe
• Alignment Length: 643
• Identity: 310/643 - (48%)
• Similarity: 425/643 - (66%)
• Gaps: 34/643 - (5%)

Human   120 DRAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLT 184
            ||.:.|:.:|:|||:..:|.||||:|||||:||.|.||::|::..||:||:.||.:||:||:|||
pombe    11 DRTQFEELMKKRFFFSPSFQIYGGISGLYDYGPPGSALQSNLVDIWRKHFVIEESMLEVDCSMLT 75

Human   185 PEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQ-KLMSDKKC-----------SVEKK- 236
            |..|||||||||||||:|.||...||.||||||::..|: :|..||:.           |.:||
pombe    76 PHEVLKTSGHVDKFADWMCKDPATGEIFRADHLVEEVLEARLKGDKEARGQNSNDQPEESDDKKK 140

Human   237 ------------------SEMESVLAQLDNYGQQELADLFVNYNVKSPITGNDLSPPVSFNLMFK 283
                              .|.|.:|||:|||...:|.:|...|::::|.|..:|..|..|||||:
pombe   141 RKKKVKEIRATRLDDKTVEEYEFILAQIDNYDGDQLGELMKKYDIRNPATNGELETPRQFNLMFE 205

Human   284 TFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTM 348
            |.|||.|.:.||||||||||.||||.||||||.||:|||:|.:|.:|||||||||||:|||||.|
pombe   206 TQIGPSGGLKGYLRPETAQGQFLNFSRLLEFNNGKVPFASAMVGKAFRNEISPRSGLLRVREFLM 270

Human   349 AEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQS-ARKMRLGDAVEQGVINNTVLGYFIGR 412
            ||:||||||..|:|.:|..|:.:.|.|.....|:.|:: ..:|.:||||::|:::||.||||:.|
pombe   271 AEVEHFVDPKNKEHDRFDEVSHMPLRLLPRGVQLEGKTDILEMPIGDAVKKGIVDNTTLGYFMAR 335

Human   413 IYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATK 477
            |.|:|.|:||..:::||||||.||||||||||||||.:.||||||.|||||||.||||.|::|||
pombe   336 ISLFLEKIGIDMNRVRFRQHMSNEMAHYACDCWDAEIQCSYGWIECVGCADRSAYDLSVHSKATK 400

Human   478 VPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLAICDECYITEMEMLLNEKGEFTI 542
            .|||.::.|.||..|...:.|.::...|..:|:|||.|.|.:....|....|....|..:|:..:
pombe   401 TPLVVQEALPEPVVVEQFEVEVNRKKFGPRFKRDAKAVEEAMISWPESEKVEKSAQLVAEGKIIV 465

Human   543 ETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSF 607
            ...|....:..|::.:::.:.|.::....|||||||||||||:|.:.||.:..|..|..|...||
pombe   466 NVNGVEHTVESDLVTIEKRKHTEHIRTYTPNVIEPSFGLGRILYVLMEHAYWTRPEDVNRGVLSF 530

Human   608 PAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGVAFGVTI 672
            ||.:||.|..::|||:|.||.||||:||..|...|:|:|:|||:.:|||||||.||:|..||:|:
pombe   531 PASIAPIKALIVPLSRNAEFAPFVKKLSAKLRNLGISNKIDDSNANIGRRYARNDELGTPFGLTV 595

Human   673 DFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVEARYPLFEGQE 730
            ||:|:..  .|.|||:|||.:|:|....|:.:.:..:..|..::.|..|::..|:..:
pombe   596 DFETLQN--ETITLRERDSTKQVRGSQDEVIAALVSMVEGKSSFEDALAKFGEFKSTQ 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GARS1	NP_002038.2	PLN02734	61..724	CDD:178335	309/635 (49%)
grs1	NP_593935.1	PLN02734	3..644	CDD:178335	309/634 (49%)