Protein Alignment GARS1 and gars-1

DIOPT Version :10

• Sequence 1: NP_002038.2
• Gene: GARS1 / 2617
• HGNCID: 4162
• Length: 739
• Species: Homo sapiens
• Sequence 2: NP_498093.1
• Gene: gars-1 / 175703
• WormBaseID: WBGene00001744
• Length: 742
• Species: Caenorhabditis elegans
• Alignment Length: 731
• Identity: 396/731 - (54%)
• Similarity: 519/731 - (70%)
• Gaps: 21/731 - (2%)

Human     1 MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCPPISLPAAASRSSMDGAGAEEVLA 65
            :||.|...|:..:     ::.||...:....:...|...:.|.|                |..||
 Worm    32 VPSDRKTPLQPRK-----VVAPRFEKKTRQKISDYLKQMATPEI----------------EAKLA 75

Human    66 PLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVDRAKMEDTLKR 130
            |||.||::.|||:|.||...||::|:||||.|||||||:||..|:||.||:...||.|:||.|||
 Worm    76 PLRAAVKEYGDLIRDLKAKGAPKIDIDKAVVELKARKRLLEDTEIALAPKEASFDRLKLEDLLKR 140

Human   131 RFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLTPEPVLKTSGHV 195
            ||||||:|||||||:|||||||:||:||.|::|.||:|||.||.:||:|||.||||||||.||||
 Worm   141 RFFYDQSFAIYGGVTGLYDFGPMGCSLKANMLQEWRKHFILEEGMLEVDCTSLTPEPVLKASGHV 205

Human   196 DKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLAQLDNYGQQELADLFVN 260
            |:|||:||||:|||||||||||:|..::||::|||.|...|.:.:.|||:|:.:..:::.::...
 Worm   206 DRFADWMVKDMKNGECFRADHLIKNSIEKLLNDKKTSAAVKQDGQDVLARLEGFDNKDMHEVITR 270

Human   261 YNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQ 325
            :|.|||||||||:.|::|||||.|.|||.|:...:||||||||||:|||||||||||||||||||
 Worm   271 FNFKSPITGNDLTEPIAFNLMFPTQIGPTGDFKAFLRPETAQGIFVNFKRLLEFNQGKLPFAAAQ 335

Human   326 IGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQSARKM 390
            ||..||||||||.||||||||||.||||||||.:|...||..|||..|.|:||..|:.|..|:::
 Worm   336 IGLGFRNEISPRQGLIRVREFTMCEIEHFVDPEDKSLAKFAKVADQKLVLFSACNQLDGAPAQEV 400

Human   391 RLGDAVEQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGW 455
            .:|:||.:..:.|..|||::.|.:.:|.||||...:||||||:.|||||||.||||||..|||||
 Worm   401 AIGEAVAKKTVANETLGYYMARCHQFLMKVGIDGRRLRFRQHLSNEMAHYAQDCWDAEILTSYGW 465

Human   456 IEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLA 520
            ||.||.|||:||||..|.:||.|.|||||.|.||..||.|:.:.:...:||::|||||.:...|.
 Worm   466 IECVGNADRACYDLQQHYKATNVKLVAEKKLPEPVDVNFVEAQANMALLGKSFKKDAKKIQTSLQ 530

Human   521 ICDECYITEMEMLLNEKGEFTIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIM 585
            ......::.:|..|..|..:.:..:|:.:.||.:.:|:|::.|.::|:|:.|:|||||:|:||||
 Worm   531 QLTSEQVSALEEELLAKKLYNLSVDGQNYALTPEHLNIKKYTKKIHVQEITPSVIEPSYGIGRIM 595

Human   586 YTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDS 650
            |.:.||:|..|||||||||.:|..:|||.||||||:|.|...:|.:..:.|.|:|..:|:|||||
 Worm   596 YALLEHSFRQREGDEQRTFLAFKPLVAPIKCSVLPISANDTLIPVMDAVKEELSRFEMSYKVDDS 660

Human   651 SGSIGRRYARTDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNIT 715
            ||:||||||||||||:.||:|:|||::..||.|.|:|..::|.|||.|:|||..::.||..|...
 Worm   661 SGTIGRRYARTDEIGIPFGITVDFDSLKTTPFTVTIRHAETMSQIRLEVSELGRLISDLVAGRQQ 725

Human   716 WADVEARYPLFEGQET 731
            |:|.:|:||.||...|
 Worm   726 WSDAQAKYPKFEASAT 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GARS1	NP_002038.2	PLN02734	61..724	CDD:178335	382/662 (58%)
gars-1	NP_498093.1	PLN02734	69..742	CDD:178335	388/689 (56%)