DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SENP3 and Ulp1

DIOPT Version :9

Sequence 1:	NP_056485.2	Gene:	SENP3 / 26168	HGNCID:	17862	Length:	574	Species:	Homo sapiens
Sequence 2:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster

Alignment Length:	666	Identity:	134/666 - (20%)
Similarity:	230/666 - (34%)	Gaps:	165/666 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    43 KSGGGFGP--DPGSGTTVPARRLPVPRP----------SFDASASEEEEEE------EEEEDEDE 89
            ::|.|||.  .|.:......||.....|          ||....:.|..|:      ..:.|:.:
  Fly   875 QNGKGFGAGRQPENSFLSQKRRNQEENPRLIKYRRVDNSFPRLITNETAEDLIPNNSMAKRDQPQ 939

Human    90 EEEVAAWRLPPRWSQLGT-SQRPRPSRPTHRKTCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGR 153
            ..:..:...||.::|... :..|....|...:..|||...|..:.|.:.||.:..|..:.....|
  Fly   940 SSKRLSIFNPPVYTQHRVRNDAPHVPTPFDDEESSQRLANAGPSSRPMTYSDAVRLGHNGISESR 1004

Human   154 HRG-------------RRRGLAHPKN---------------------HLSP------QQGGATPQ 178
            ..|             .|..|:|..|                     :|.|      |:..|...
  Fly  1005 VNGHSSHTVRREPSRLHRSILSHEMNCKDQEQYNELIRTQTNYVGSRYLKPGTPPTFQRAKAQSA 1069

Human   179 VPSPCC----------RFDSPRGPPPPRLGLLGALM-AEDGVRGSPPVPSGPPMEEDGLRWTPKS 232
            ..|.|.          .|.||.|...|.|.....|: .::......|.|..|.........:..|
  Fly  1070 TSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPKRNASNSSASHAS 1134

Human   233 PLDPDSGLLSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSIGD------HVAQELFQGSDLG 291
            .:. .|...||:                         ..:.||..|      ..:.|:.:.::..
  Fly  1135 TIS-SSASSSCS-------------------------TCSTCSSSDTEPMLVKDSPEVKEANEAN 1173

Human   292 MAEEAERPGEKAGQHSP------------LREEHVTCVQSILDEFLQTYGS-----------LIP 333
            .|.||....|.....:|            |......|: .:.::|.:.:.:           |:.
  Fly  1174 EANEANEANETKENDAPQPTTTRIKKPDFLHRRFANCI-FLRNDFAENFKARANRRQLESMHLLG 1237

Human   334 LSTDEVVE----------KLEDIFQQEFSTPSRKGLVLQLIQS-------------------YQR 369
            ::..:..|          ||.::..:. ..|.|....:..::.                   :|.
  Fly  1238 IAEQQANESKDERLAYEKKLREVMFRS-GAPHRPFFEIGPLEQPEEKKETKLIPLTKEDHARFQE 1301

Human   370 MPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPEK------VHFFNSF 428
            |....:.......|...: |.||:.|.....||||.::|.|..::.:...::      .:..|:|
  Fly  1302 MTTIEVTTNLIFKYNLQI-TTDDIFTFVDGEWLNDAIINFYMSMLTERSEKRAGELPATYAMNTF 1365

Human   429 FYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHL-EVHWSLISVDVRRRTITYFDSQRTLNRRCP 492
            |..:|...||.||:|||:.||:|:|:::.:|:|. .|||.:..:.:|.:||.|:||....|:...
  Fly  1366 FMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRNKTIFYYDSMGRPNQPAL 1430

Human   493 KHIAKYLQAEAVKKDRLDFHQ-GWKGYFKMNVARQNNDSDCGAFVLQYCKHLALSQPFSFTQQDM 556
            ..:.|||..|::.|.:..|.. |:......|:.||.|.||||.|...:.:::....|.:|:|.:|
  Fly  1431 DALVKYLHEESLDKRKQPFDMTGFVVENAQNIPRQGNSSDCGVFSCMFAEYITRDVPITFSQAEM 1495

Human   557 PKLRRQIYKELCHCKL 572
            ...|.::..|:...||
  Fly  1496 LYFRTKMALEIADGKL 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SENP3	NP_056485.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..125		19/100 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	125..128		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000255	153..159		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..181		7/46 (15%)
		Protease	386..543		53/164 (32%)
		Peptidase_C48	400..572	CDD:280975	55/179 (31%)
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	54/174 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850