Protein Alignment Unc-115a and ABLIM3

DIOPT Version :10

• Sequence 1: NP_001163573.1
• Gene: Unc-115a / 261629
• FlyBaseID: FBgn0051352
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_055760.1
• Gene: ABLIM3 / 22885
• HGNCID: 29132
• Length: 683
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 270/845 - (31%)
• Similarity: 362/845 - (42%)
• Gaps: 226/845 - (26%)

  Fly    44 IYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANC 108
            |.|.:|...|.|||:||.:||||..||.|..|...||..|||.|:..|.|..|||:||||:|.:|
Human    21 IQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSC 85

  Fly   109 QQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGV 173
            :.::.|||:|.:|:|||.|||.||.|::||..|.|||.:|||.:|:.|
Human    86 RDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTC----------------- 133

  Fly   174 SSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRC 238
             |.:..:..|.:...                   |:.||||.|.:|.||:|:|||:|||||||:|
Human   134 -SQSMASSKPIKIRG-------------------PSHCAGCKEEIKHGQSLLALDKQWHVSCFKC 178

  Fly   239 KACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDP 303
            :.|..:|.|||:.||.|||||..|...||:||..|.|:|||:||:|| ..|:|||||||.:|...
Human   179 QTCSVILTGEYISKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAG-GKHYHPTCARCVRCHQM 242

  Fly   304 FGDGEEMYLQGSAIWHPRCGPGP-SESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEM 367
            |.:||||||.||.:|||.|.... :|..:.......||....|:|.|:.....|.::.:..|:..
Human   243 FTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVDNEILNYK 307

  Fly   368 YIRSRTPSFNGSLYSSSR-------KHYRTVSPGLILR-EYGR------PNAEDISRIYTYSYL- 417
            .: :..|... |:|...|       .|.|.:|..::.| .||.      |.::||     |..|
Human   308 DL-AALPKVK-SIYEVQRPDLISYEPHSRYMSDEMLERCGYGESLGTLSPYSQDI-----YENLD 365

  Fly   418 -----TDAPHYLRKPIDPYDKTPLSPHFHR-PSSYATTASNAGSVAGSRPPSRP-HSRTRSAMKV 475
                 ..:|.|:..|  .|.:..:||.|.| |..|..:...:|.       |.| ||:
Human   366 LRQRRASSPGYIDSP--TYSRQGMSPTFSRSPHHYYRSGPESGR-------SSPYHSQ------- 414

  Fly   476 LVDAIRSETP----RPKSPGMNNEEPIELSHYPAA-----KKPPPGEQPKIERDDFPAPPYPYT- 530
             :| :||.||    .||.           .|.||.     :|||..::    ..|........|
Human   415 -LD-VRSSTPTSYQAPKH-----------FHIPAGDSNIYRKPPIYKR----HGDLSTATKSKTS 462

  Fly   531 -DPERRRRYSDTYKGVPASDDEDEN-VENGKPN----GKVKNGEEQQRLQREAEQLEKLNSGIGS 589
             |..:..:||..|...|....|.|. ..:|.|.    .:..:|.|:....|   .:.||.||||.
Human   463 EDISQTSKYSPIYSPDPYYASESEYWTYHGSPKVPRARRFSSGGEEDDFDR---SMHKLQSGIGR 524

  Fly   590 AIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASP-SRNLDHQKPFYEDEM 653
            .|   |||..|.|  ..:..||....|:.::|:|.|:...||..:..|| |..|....|...
Human   525 LI---LKEEMKAR--SSSYADPWTPPRSSTSSREALHTAGYEMSLNGSPRSHYLADSDPLIS--- 581

  Fly   654 FDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGFKTTTLP-YIRNGFSSDFSYGGLGDKTHS 717
                                                 |:.:|| |.|||.          .:|.|
Human   582 -------------------------------------KSASLPAYRRNGL----------HRTPS 599

  Fly   718 TDLSCGKSEASVDSITEGDRRALMGGDLPASSTYSGALSYHYPQAGLIRRSLPNMSHSMLVHEPA 782
            .||                                    :||.....:...:          ...
Human   600 ADL------------------------------------FHYDSMNAVNWGM----------REY 618

  Fly   783 KIYPYHLLLIT---NYRLPSDVDRCNLERHLSDIEFEHILQCARSEFYRLPQWRRNELKRRVKLF 844
            |||||.|||:|   ..|||.||||..||||||..||..:.....|||.||..|:|||||::.:||
Human   619 KIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGMTISEFDRLALWKRNELKKQARLF 683

  Fly   845  844
            Human   684  683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115a	NP_001163573.1	LIM1_abLIM	46..97	CDD:188713	24/50 (48%)
		LIM2_abLIM	102..157	CDD:188714	28/54 (52%)
		LIM3_abLIM	211..262	CDD:188715	32/50 (64%)
		LIM4_abLIM	270..326	CDD:188716	32/55 (58%)
		VHP	809..844	CDD:460493	16/34 (47%)
ABLIM3	NP_055760.1	LIM1_abLIM	23..74	CDD:188713	24/50 (48%)
		LIM2_abLIM	79..134	CDD:188714	29/72 (40%)
		LIM3_abLIM	151..202	CDD:188715	32/50 (64%)
		LIM4_abLIM	210..265	CDD:188716	32/55 (58%)
		AbLIM_anchor	273..633	CDD:465046	111/503 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..472		31/132 (23%)
		VHP	648..683	CDD:128458	16/34 (47%)