Protein Alignment Unc-115a and Ablim1

DIOPT Version :10

• Sequence 1: NP_001163573.1
• Gene: Unc-115a / 261629
• FlyBaseID: FBgn0051352
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_848803.3
• Gene: Ablim1 / 226251
• MGIID: 1194500
• Length: 861
• Species: Mus musculus
• Alignment Length: 1002
• Identity: 301/1002 - (30%)
• Similarity: 397/1002 - (39%)
• Gaps: 386/1002 - (38%)

  Fly     7 ISIPKHPQTDKTRPIYPSTLGTELRTELGKTGQGKQKIYCAKCTKKCSGEVLRVADNHFHKACFQ 71
            ::.|:.|.....:|:                      |:|.||.:.|.||||||...|||..||.
Mouse    82 VAHPQDPHHSSEKPV----------------------IHCHKCGEPCKGEVLRVQTKHFHIKCFT 124

  Fly    72 CCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANCQQYVEGEVVSTMGKTYHQKCFTCSKCKQ 136
            |..|...||.||||.|:..|.|..||||:|||:|..|.::||||||:.:|||||..||.|:.||:
Mouse   125 CKVCGCDLAQGGFFIKNGDYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKR 189

  Fly   137 PFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGVSSPAPPAESPTRATAHQQHGSVISHKAH 201
            ||..|.:||..|::.||:.|.                   .|.:.||..|:.
Mouse   190 PFPPGDRVTFNGRDCLCQLCA-------------------QPMSSSPKEASC------------- 222

  Fly   202 LKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRCKACQAVLNGEYMGKDAVPYCEKCYQKGF 266
                  .::|||||..:|.||||:|||:|||:.||:||:|..||.|||:.||..|||||.||..|
Mouse   223 ------SSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGSPYCEKDYQGLF 281

  Fly   267 GVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDPFGDGEEMYLQGSAIWHPRC--------- 322
            ||||..|.:||:||||:|||. |:||:||||::|...|.:|||||||||.:|||.|
Mouse   282 GVKCEACHQFITGKVLEAGDK-HYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEK 345

  Fly   323 -----------------------GPGP-----------------------SESGIILNGGGGTSS 341
                                   |..|                       |...|....|   ||
Mouse   346 LRPPNIPRSSSDFFYPKSLIRRTGRSPALQLLSPPCLMNSNKNPRQPTRTSSESIYSRPG---SS 407

  Fly   342 VVGGASNGNF--TDTEC-----------------------------------DRMSSSALSEM-Y 368
            :.|...:..:  .|.|.                                   |:....:|.|. .
Mouse   408 IPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYEDKQERQSLGESPR 472

  Fly   369 IRSRTPSFNGSLYSSSRKHYRTVSPGLILREYGRPNAEDISRIYTYSYLTDAPHYLRKPIDPYDK 433
            ..|.|||..|......|..:|:.|.|.|                      ::|.|.|....|  .
Mouse   473 TLSPTPSAEGYQDVRDRMIHRSTSQGSI----------------------NSPVYSRHSYTP--T 513

  Fly   434 TPLSP-HFHRP---------------SSYATTASNAGSVAGSRPPSR-----------PHSRTRS 471
            |..|| |||||               ||:::|.|:    :...||.|           |.|...|
Mouse   514 TSRSPQHFHRPELLSPGVHRWSPLRTSSFSSTHSD----SRPNPPFRHHFLPHVKGNEPSSGRNS 574

  Fly   472 AMKVLVDAIRSETP----RPK-----SPGMN--------------------NEEPIELSHYPAAK 507
            .:....|: |..||    .||     ..|:|                    :|:.|:.|.:|||:
Mouse   575 PLPYRPDS-RPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAALAAQSKASEDIIKFSKFPAAQ 638

  Fly   508 KPPPGEQPKIERDDFPAPP---YPYTDPERRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEE 569
            .|.|.|.||||.|.:|.||   ...|||.||          .:..:|||.             |.
Mouse   639 APDPNEIPKIETDHWPGPPSLAAVGTDPRRR----------SSGREEDEE-------------EL 680

  Fly   570 QQRLQREAEQLEKLNSGIGSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPI 634
            .:|.|.:.|||.|||||:|..|.|:             .::..:..|...||       ||:||:
Mouse   681 LRRRQLQEEQLMKLNSGLGQLILKE-------------EMEKESRERASLAS-------RYDSPL 725

  Fly   635 GASPSRNLDHQKPFYEDEMFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGFKTTTLP-YI 698
                                           .|..:|||                .||::|| |.
Mouse   726 -------------------------------HSASHAPS----------------SKTSSLPGYG 743

  Fly   699 RNGF----SSDF----SYGGLGDKTHSTDLSCGKSEASVDSITEGDRRALMGGDLPASSTYSGAL 755
            :||.    |:||    |||         |:|.|..          |.:.|..|.:||.....|.
Mouse   744 KNGLHRPVSTDFAQYNSYG---------DISGGVR----------DYQTLPDGHMPAVRMDRGV- 788

  Fly   756 SYHYPQAGLIRRSLPNMSHSMLVHEPAKIYPYHLLLITN---YRLPSDVDRCNLERHLSDIEFEH 817
                        |:|||.      || ||:||.:|::||   .::..||||..|||||:...|..
Mouse   789 ------------SMPNML------EP-KIFPYEMLMVTNRGRNKILRDVDRTRLERHLAPEVFWE 834

  Fly   818 ILQCARSEFYRLPQWRRNELKRRVKLF 844
            |...:..||.:||.||||::|::.|||
Mouse   835 IFGMSIQEFDKLPLWRRNDMKKKAKLF 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115a	NP_001163573.1	LIM1_abLIM	46..97	CDD:188713	26/50 (52%)
		LIM2_abLIM	102..157	CDD:188714	28/54 (52%)
		LIM3_abLIM	211..262	CDD:188715	33/50 (66%)
		LIM4_abLIM	270..326	CDD:188716	34/87 (39%)
		VHP	809..844	CDD:460493	14/34 (41%)
Ablim1	NP_848803.3	LIM1_abLIM	99..150	CDD:188713	26/50 (52%)
		LIM2_abLIM	155..210	CDD:188714	28/54 (52%)
		LIM3_abLIM	226..277	CDD:188715	33/50 (66%)
		LIM4_abLIM	285..340	CDD:188716	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..414		6/42 (14%)
		AbLIM_anchor	393..811	CDD:465046	136/578 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	459..590		39/159 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..682		23/70 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..748		18/88 (20%)
		VHP	826..861	CDD:128458	14/34 (41%)