Protein Alignment Unc-115a and Unc-115a

DIOPT Version :10

• Sequence 1: NP_001163573.1
• Gene: Unc-115a / 261629
• FlyBaseID: FBgn0051352
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_061506688.1
• Gene: Unc-115a / 1276123
• VectorBaseID: AGAMI1_005404
• Length: 840
• Species: Anopheles gambiae
• Alignment Length: 860
• Identity: 573/860 - (66%)
• Similarity: 655/860 - (76%)
• Gaps: 76/860 - (8%)

  Fly    40 GKQKIYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTK 104
            ||.||.|:||.||||||||||:|.:|||.||||.:|.|||||||||:||.||||..|||:|||||
Mosquito     2 GKSKIQCSKCQKKCSGEVLRVSDRYFHKTCFQCTKCNKSLATGGFFSKDGAYYCTLDYQKLYGTK 66

  Fly   105 CANCQQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCV------------ 157
            ||.|.||||||||||||.||||||||||||||||||||||||||||||||.||
Mosquito    67 CAACSQYVEGEVVSTMGNTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCESCVKCPPGSGVGGGG 131

  Fly   158 ----TGAPVSPS-----RQATGGGVSSPAPPA--------------ESPTRATAHQQHGSVISHK 199
                ||:|...:     :..||....||...|              .|||:|...|.|...:..:
Mosquito   132 GATATGSPTVGAAAGVVQGGTGSATVSPKSRAIEQKQEQRTIKEITSSPTKAATLQHHQETVKKQ 196

  Fly   200 AHLKED----YDPNDCAGCGELLKEGQALVALDRQWHVSCFRCKACQAVLNGEYMGKDAVPYCEK 260
            ..|.::    .||||||||.:.|||||||:|||||||:.||:|.||...|||||||||.||||||
Mosquito   197 QQLLQNGGKQPDPNDCAGCQQQLKEGQALIALDRQWHIWCFKCNACGTTLNGEYMGKDGVPYCEK 261

  Fly   261 CYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDPFGDGEEMYLQGSAIWHPRCGPG 325
            .:||.||||||:|:|:||||||||||||||||||||||||||||||||||||||.||||||||||
Mosquito   262 DFQKSFGVKCAHCNRYISGKVLQAGDNHHFHPTCARCTKCGDPFGDGEEMYLQGGAIWHPRCGPG 326

  Fly   326 PSESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEMYI--RSRTPSFNGSLYS--SSRK 386
            ||....||||..         :||..|:||.||.|:|.:||:..  ||:|||.|||:||  :.||
Mosquito   327 PSSEAGILNGVD---------TNGFNTETEFDRTSTSGMSEIQFTYRSQTPSVNGSVYSPYTHRK 382

  Fly   387 HYRTVSPGLILREYGRPNAEDISRIYTYSYLTDAPHYLRKPIDPYDKTPLSPHFHRPSSYAT--- 448
            ::||.|||||||||.....|||:|||||||||:.|.|||:||:|||:.|:|||||||..:.:
Mosquito   383 YHRTTSPGLILREYKNQGYEDIARIYTYSYLTEEPGYLRRPIEPYDRAPVSPHFHRPVQHYSSMG 447

  Fly   449 ---TASNAGSVAGSRPPSRPHSRTRSAMKVLVDAIRSETPRPKSPGMNNEEPIELSHYPAAKKPP 510
               |||:.|:.:.|  .||.|||:|||||||||:|||||||||||||||||||||||||||||||
Mosquito   448 VGGTASSIGTRSAS--GSRSHSRSRSAMKVLVDSIRSETPRPKSPGMNNEEPIELSHYPAAKKPP 510

  Fly   511 PGEQPKIERDDFPAPPYPYTDPERRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEEQQRLQR 575
            |||:||||||||||||||||||||||||||:|||||.||||.::..|       |....::|..:
Mosquito   511 PGEKPKIERDDFPAPPYPYTDPERRRRYSDSYKGVPESDDEVDHANN-------KENVTEKRHTK 568

  Fly   576 EAEQLEKL-NSGIGSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASPS 639
            |.|:|.|| :||:|:.|.|||:|..:|..|||.|||||||||||||||||:|::|||||:|||||
Mosquito   569 EEEELRKLKSSGMGTVILKDLQEKKRYEHWKQENLDPRNASRTPSASKEPMYRMRYESPVGASPS 633

  Fly   640 RNLDHQKPFYEDEMFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGF--KTTTLPYIRNGF 702
            ||||||||||||| ||||||||||:|:::|||.|||.:.|.|..||||||.  ::.|.....:|.
Mosquito   634 RNLDHQKPFYEDE-FDRSTSYRGSVGRAIGNATSYNVVSSLRQVPKPGYGLAPRSHTFSSATSGS 697

  Fly   703 S---SDFSYGGLGDKTHSTDLSCGKSEASVDSITEGDRRALMGGDLPASSTYSGALSYHYPQAGL 764
            :   .|||:.|||||||||:.|||||:.|.||||||||||| |.:|||||||||||||||||..
Mosquito   698 AHGVPDFSFSGLGDKTHSTEFSCGKSDISGDSITEGDRRAL-GAELPASSTYSGALSYHYPQQP- 760

  Fly   765 IRRSLPNMSHSMLVHEPAKIYPYHLLLITNYRLPSDVDRCNLERHLSDIEFEHILQCARSEFYRL 829
            .|||||||:|||||||||||||||||||||||||||||||||||||||:|||.||||.|.||||:
Mosquito   761 TRRSLPNMAHSMLVHEPAKIYPYHLLLITNYRLPSDVDRCNLERHLSDVEFEAILQCTRPEFYRM 825

  Fly   830 PQWRRNELKRRVKLF 844
            |||:||::|||.:||
Mosquito   826 PQWKRNDMKRRARLF 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115a	NP_001163573.1	LIM1_abLIM	46..97	CDD:188713	37/50 (74%)
		LIM2_abLIM	102..157	CDD:188714	50/54 (93%)
		LIM3_abLIM	211..262	CDD:188715	38/50 (76%)
		LIM4_abLIM	270..326	CDD:188716	51/55 (93%)
		VHP	809..844	CDD:460493	24/34 (71%)
Unc-115a	XP_061506688.1	None