Protein Alignment CG31495 and Spast

DIOPT Version :10

• Sequence 1: NP_731866.1
• Gene: CG31495 / 261626
• FlyBaseID: FBgn0051495
• Length: 341
• Species: Drosophila melanogaster
• Sequence 2: NP_001156342.1
• Gene: Spast / 50850
• MGIID: 1858896
• Length: 614
• Species: Mus musculus
• Alignment Length: 195
• Identity: 48/195 - (24%)
• Similarity: 82/195 - (42%)
• Gaps: 21/195 - (10%)

  Fly   129 LVEGKPKSGLTTVAAQMALKTDCPFIKYISSAELLGLSDSEKCQRIREVLEDAYVSRRSCVIIDD 193
            |:.|.|.:|.|.:|..:|.:::..|.. ||:|.|......|..:.:|.:...|...:.|.:.||:
Mouse   377 LLFGPPGNGKTMLAKAVAAESNATFFN-ISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 440

  Fly   194 F-----ERVIGYGALGKRYSKEFLQKLTVLLKKQPPNSHELIIICTSNRLDVLEELGLLSVFTSV 253
            .     ||..|.....:|...|||.:...:   |......::::..:||...|:|..|......|
Mouse   441 VDSLLCERREGEHDASRRLKTEFLIEFDGV---QSAGDDRVLVMGATNRPQELDEAVLRRFIKRV 502

  Fly   254 H-NVPNVSTPKELM--VIVEASKRFEPEELRQIEIAMDGRNVSIGIKRLLDLIAWVN--SLNPDR 313
            : ::||..|...|:  ::.:.......:||.|:....||.:.|       ||.|...  :|.|.|
Mouse   503 YVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGS-------DLTALAKDAALGPIR 560

  Fly   314  313
            Mouse   561  560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31495	NP_731866.1	SpoVK	<1..88	CDD:440232
		AAA	129..257	CDD:459627	32/133 (24%)
Spast	NP_001156342.1	Required for interaction with RTN1. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..298
		Required for midbody localization. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..192
		Required for interaction with ATL1. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..78
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..48
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021	4..11
		Required for interaction with SSNA1 and microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0	48..85
		Nuclear export signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021	57..65
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..112
		Sufficient for interaction with CHMP1B. /evidence=ECO:0000250|UniProtKB:Q9UBP0	110..194
		Required for interaction with microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0	112..198
		MIT_spastin	114..193	CDD:239142
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..306
		Sufficient for microtubule severing. /evidence=ECO:0000250|UniProtKB:Q9UBP0	226..614		48/195 (25%)
		Required for interaction with microtubules and microtubule severing. /evidence=ECO:0000250|UniProtKB:Q9UBP0	268..326
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021	307..310
		Required for interaction with microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0	308..310
		RecA-like_spastin	341..504	CDD:410932	32/130 (25%)
		AAA_lid_3	531..585	CDD:465537	12/37 (32%)
		Vps4_C	<578..610	CDD:462762