DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and Galnt5

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_113984.1	Gene:	Galnt5 / 83627	RGDID:	620361	Length:	930	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	195/541 - (36%)
Similarity:	291/541 - (53%)	Gaps:	59/541 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 GEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIF 184
            |:.|..|.:. |.:|:..::.::...||..:||.|.|:|::.|.|...|..:.....||..|:|.
  Rat   429 GQFGRPVVVP-PGKKKEAEQRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNDLPTTSIIM 492

  Fly   185 IFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPER 249
            .|.:|.::.||||::||:||:||.|:|:|:||||.|..|.||..||.|:.| ||. |.|:|..||
  Rat   493 CFVDEVWSALLRSVHSVLNRSPPHLIKEILLVDDFSTKDYLKANLDKYMSQ-FPK-VRILRLKER 555

  Fly   250 QGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSG 314
            .|||.||:|||:.|.|.|:.|.|||:|.|..||.||:|.:.:|.|...||:::.|:.:|.||.:.
  Rat   556 HGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTV 620

  Fly   315 NKDGARGGFDWKMLY--KQLP--VLPEDALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDI 375
            : :..||.|.|.|.:  :.:|  |:.::.:.::...|.|||.||||:|:..:|::||.||..||:
  Rat   621 D-NFQRGVFTWPMNFGWRTIPPDVIAKNGIKETDIIRCPVMAGGLFSIDKSYFYELGTYDPGLDV 684

  Fly   376 WGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGH-NFVAKNHKRVAEVWMDEYKQ 439
            ||||..|||||:|||||.:..:|||||.||||.. .|...|:.. ..|.:|..||||||:||||:
  Rat   685 WGGENMELSFKVWMCGGEIEIIPCSRVGHIFRND-NPYSFPKDRMKTVERNLVRVAEVWLDEYKE 748

  Fly   440 YVYKRDPKTYD-NLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNV 503
            ..|.......| .||.|:||:||.:|::|||:||.|::..|.||  :|.|.|.    |:|:..|:
  Rat   749 LFYGHGDHLIDQGLDVGNLTQQRELRKKLKCQSFKWYLDNVFPD--LKAPVVR----ASGVFINL 807

  Fly   504 ANPVYCLDNMGKST---EEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPPN 565
            |        :||..   ...|.:..|..:....|.|..|       :|:......|  |...|..
  Rat   808 A--------LGKCVSIKNITVVLEDCDGSSELQQFNYTW-------VRLIKHGEWC--VAPIPDK 855

  Fly   566 ATVWMWSCHSQGGNQFWYYDRQTQRLVHGE----------NNKRCLEGFVENGIAKVVANSCENG 620
            .::.::.|.::.....|.:  ::....|.|          ....|:||.......|:.|  |...
  Rat   856 GSLTLYPCDNRNNRLKWLH--RSASAFHPELVDHIVFESYQQLLCMEGNFSQKTLKLAA--CNPT 916

  Fly   621 NDRQRWEFGFVNHTMLDTFYD 641
            ..:|:|:|        :.:||
  Rat   917 EPQQKWKF--------EKYYD 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	109/237 (46%)
		pp-GalNAc-T	181..480	CDD:133004	142/304 (47%)
		Ricin_B_lectin	496..626	CDD:279046	26/142 (18%)
		RICIN	498..628	CDD:238092	26/142 (18%)
Galnt5	NP_113984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..210
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377
		WcaA	484..>599	CDD:223539	60/116 (52%)
		Catalytic subdomain A	485..594		59/110 (54%)
		pp-GalNAc-T	489..790	CDD:133004	142/304 (47%)
		Catalytic subdomain B	654..716		37/61 (61%)
		RICIN	804..925	CDD:214672	26/149 (17%)
		RICIN	810..924	CDD:238092	23/126 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810