DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and galnt10

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001072444.1	Gene:	galnt10 / 779898	XenbaseID:	XB-GENE-1010672	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	647	Identity:	258/647 - (39%)
Similarity:	369/647 - (57%)	Gaps:	63/647 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRYVKRLLRKVVLLLVVIVTVSLVTTLVVERRMKNAAELTEQLDPNGDPITPVFRAANIHPTRKA 69
            :|..||:|:.|.|.:..::.:..|....:.|.        :||:           :|......||
Frog     2 RRKEKRILQAVGLAVAALLFLPNVGLWSLYRE--------KQLE-----------SAGARDLEKA 47

  Fly    70 PRPPFQDRNSVVDI-PRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENPDE 133
                   |..|:.: ||.:|:.     |...|:||||:|..:..:.::.|.||.|....:.:.|.
Frog    48 -------RGEVLFVKPRDEKVN-----EKVPEKKDWHNYEQIRKESEQIGNGEQGKPFPMTDADH 100

  Fly   134 KQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSI 198
            ..   :.|..||||..:||:||:|||:||:|...||.:.|.:||||.|||..|.||.:::|||::
Frog   101 VD---QAYRENGFNIFVSDKISLNRSLPDIRNSNCKNKFYFSKLPNTSVIIPFHNEGWSSLLRTV 162

  Fly   199 YSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVA 263
            :||:||:||||:.:||||||.|:...||..|:.|: .:||. |.|||..:|:|||..|:.||.||
Frog   163 HSVLNRSPPELIAEIVLVDDYSDKAHLKSRLEKYM-ANFPK-VKIVRTKKREGLIRTRMLGATVA 225

  Fly   264 VGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKML 328
            .|:|:.|.|||.|.|.||||||::|:..|.|...|||:|.|..::|.|.:...|..||.|||:|.
Frog   226 SGEVLTFLDSHCEANVNWLPPLLDPLVQNYKTVVCPMIDVIDSDNFGYVTQAGDAMRGAFDWEMF 290

  Fly   329 YKQLPVLPE-DALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGG 392
            ||::|:.|| ...|.|.|:.||||.|||||||.::||.|||||..|:||||||||:|||:|||||
Frog   291 YKRIPIPPELQKGDPSDPFDSPVMAGGLFAINREWFWQLGGYDPGLEIWGGEQYEISFKVWMCGG 355

  Fly   393 MLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDAGDL 457
            .::|.|||||.||:| ...|...|.|.: :|:|.|||||||||||.:|:|:|.| .|.:|..||:
Frog   356 RMVDSPCSRVGHIYR-KYVPYKVPAGVS-LARNLKRVAEVWMDEYAEYIYQRRP-DYRHLSVGDV 417

  Fly   458 TRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTEEAVG 522
            ..|:.:|.:|:|:.|.|||.|:|.|....:||||.|..|.|.|:||...: |:.....::...:.
Frog   418 AAQKELRRKLQCRDFKWFMNEIAWDLPKYYPPVELPPAAWGEIRNVRMDM-CVGVKHVTSGTEIR 481

  Fly   523 MFSCADNRTHPQ--PNQFWELSIFRDLR-------MKG-FDSVCLDVHEGPPNATVWMWSCHSQG 577
            :.:|...|....  ..|.:.|....|:|       ||. ||:|       ...:.|.::.||...
Frog   482 LEACNKGRNSDTWGARQVFTLGWREDIRPGIPQHTMKSCFDAV-------SQTSPVTLFDCHGMK 539

  Fly   578 GNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEFGFVNHTMLDTF 639
            |||.|.| |:.:.:.|..:|. |::  ...|..|:..|.|...:..|:|.|..:|.|:|:.|
Frog   540 GNQLWKY-RRDKTVYHPTSNS-CMD--CNEGEYKIFMNKCNPSSPTQQWTFEHINSTILEAF 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	128/234 (55%)
		pp-GalNAc-T	181..480	CDD:133004	159/299 (53%)
		Ricin_B_lectin	496..626	CDD:279046	34/139 (24%)
		RICIN	498..628	CDD:238092	34/139 (24%)
galnt10	NP_001072444.1	pp-GalNAc-T	145..440	CDD:133004	159/299 (53%)
		Glyco_tranf_2_2	145..408	CDD:287123	146/267 (55%)
		Ricin_B_lectin	456..584	CDD:279046	34/139 (24%)
		RICIN	458..586	CDD:238092	34/139 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4001
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1268
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144590at33208
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	1	1.000	-	-		mtm9549
Panther	1	1.100	-	-	O	PTHR11675
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160