DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and galntl6

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001139074.1	Gene:	galntl6 / 568915	ZFINID:	ZDB-GENE-090312-115	Length:	600	Species:	Danio rerio

Alignment Length:	664	Identity:	263/664 - (39%)
Similarity:	367/664 - (55%)	Gaps:	100/664 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRYVKRLLRKVVLLLVVIVTVSLV--TTLVVERRMKNAAELTEQLDPNGDPITPVFRAANIHPTR 67
            ||..||:|:...|.:|.::.:..|  .::..|:.:..:.|..||..|.|      ....:|:..
Zfish     2 KRRQKRVLQMAFLFMVALIFLPNVGLWSMYREKSLMKSHEPGEQGFPLG------LNDGHIYTW- 59

  Fly    68 KAPRPPFQDRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENPD 132
                                 ..|.|       |:|||||.::..|.:|.|.||||....:.
Zfish    60 ---------------------TDGLR-------RRDWHDYESIRKDGQRVGKGEHGKPYPLV--- 93

  Fly   133 EKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRS 197
            |.:.:...|:.||||..:|:.|:::||:||:|...||.:.||..|||.|:|..|.||.:::|||:
Zfish    94 EDECDDSVYKENGFNIYVSNNIALDRSLPDIRHPNCKQKLYLENLPNTSIIIPFHNEGWSSLLRT 158

  Fly   198 IYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKV 262
            ::|:.||||..|:.:|:||||.|:.:.||..|.:|:.: ||. |.|||..:|:|||..|:.||.|
Zfish   159 LHSISNRTPDHLIAEIILVDDYSDREHLKAHLAEYMSR-FPK-VRIVRTKKREGLIRTRLLGASV 221

  Fly   263 AVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKM 327
            |.|:|:.|.|||.|.|.||||||::.||.|||...|||:|.|.|..|.|.:...|..||.|||:|
Zfish   222 ARGEVLTFLDSHCEANINWLPPLLDQIAQNPKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEM 286

  Fly   328 LYKQLPVLPE-DALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCG 391
            .||::|:.|| ...|.|.||:||||.|||||:|..:||:|||||..|:||||||:|:|||:||||
Zfish   287 YYKRIPIPPELQGPDPSDPYQSPVMAGGLFAVNRQWFWELGGYDTGLEIWGGEQFEISFKVWMCG 351

  Fly   392 GMLLDVPCSRVAHIFRG--PMK-PRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLD 453
            |.:.|||||||.||:|.  |.| |.|..     :|:|.|||||.|||||.:|:|:|.|: |.:|.
Zfish   352 GSMYDVPCSRVGHIYRKYVPYKVPSGTS-----LARNLKRVAETWMDEYTEYIYQRRPE-YRHLS 410

  Fly   454 AGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTE 518
            .||||.|:.:|:.||||.|.|:|..||.|....:|||||...|.|.|:|.|:.: |:|:...||.
Zfish   411 TGDLTAQKELRKHLKCKDFKWYMNTVAWDLPKYYPPVEPLPAAWGEIRNAASGL-CVDSKHGSTG 474

  Fly   519 EAVGMFSC---ADNRT--HPQPNQF-WELSIFRDLRMKG--------FDSVCLDVHEGPPNATVW 569
            ..:.:.:|   ...||  |.|...| |.    .|:|...        ||::       ..|:.:.
Zfish   475 TELRLDNCLKEGAERTWAHEQIFTFGWR----EDIRPGDPLHTRKFCFDAI-------SQNSPIT 528

  Fly   570 MWSCHSQGGNQFWYYDRQTQRLVH---------GENNKRCLEGFVENGIAKVVANSCENGNDRQR 625
            ::.||...|||.|.| |:.:.|.|         ..|:||            :..|.|:..::.|:
Zfish   529 LYDCHGMKGNQHWSY-RKDKSLYHLVSSGCMDCSPNDKR------------IFMNKCDPKSETQQ 580

  Fly   626 WEFGFVNHTMLDTF 639
            |.|..||.|:||.|
Zfish   581 WIFQKVNATVLDKF 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	127/234 (54%)
		pp-GalNAc-T	181..480	CDD:133004	160/302 (53%)
		Ricin_B_lectin	496..626	CDD:279046	37/152 (24%)
		RICIN	498..628	CDD:238092	37/152 (24%)
galntl6	NP_001139074.1	pp-GalNAc-T	142..437	CDD:133004	160/302 (53%)
		Glyco_tranf_2_2	142..404	CDD:287123	144/268 (54%)
		Ricin_B_lectin	453..581	CDD:279046	37/152 (24%)
		RICIN	455..583	CDD:238092	37/152 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586984
Domainoid	1	1.000	211	1.000	Domainoid score	I2739
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1301
OMA	1	1.010	-	-		QHG48703
OrthoDB	1	1.010	-	-		D144590at33208
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	1	1.000	-	-		mtm6424
orthoMCL	1	0.900	-	-		OOG6_104854
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2546
SonicParanoid	1	1.000	-	-		X1309
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800