DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and GALNT10

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_938080.1	Gene:	GALNT10 / 55568	HGNCID:	19873	Length:	603	Species:	Homo sapiens

Alignment Length:	653	Identity:	267/653 - (40%)
Similarity:	373/653 - (57%)	Gaps:	72/653 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRYVKRLLRKVVLLLVVIVTVSLVTTLVVERRMKNAAELTEQLDPNGDPITPVFRAANIHPTRKA 69
            :|..||||:.|.|:|..:|.:..|....:.|          :..|:|   ||....|.:.|...
Human     2 RRKEKRLLQAVALVLAALVLLPNVGLWALYR----------ERQPDG---TPGGSGAAVAPAAG- 52

  Fly    70 PRPPFQDRNSVVDIPRSDKLQGFRLPEPK------GER-KDWHDYAAMEADRKRSGFGEHGVAVK 127
                                ||....:.|      |:: |||||..|:..|.:|.|.||.|....
Human    53 --------------------QGSHSRQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYP 97

  Fly   128 IENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFN 192
            :  .|.:::: :.|..||||..:||:||:|||:||:|...|.:::||..|||.|:|..|.||.::
Human    98 M--TDAERVD-QAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWS 159

  Fly   193 TLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARI 257
            :|||:::||:||:||||:.:||||||.|:.:.||:||:||:.. ||. |.|:|..:|:|||..|:
Human   160 SLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMAL-FPS-VRILRTKKREGLIRTRM 222

  Fly   258 AGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGG 322
            .||.||.|.|:.|.|||.|.|.||||||::.||.|.|...|||:|.|.|:||.|.:...|..||.
Human   223 LGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGA 287

  Fly   323 FDWKMLYKQLPVLPE-DALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFK 386
            |||:|.||::|:.|| ...|.|.|:.||||.|||||::..:||:|||||..|:||||||||:|||
Human   288 FDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFK 352

  Fly   387 IWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDN 451
            :|||||.:.|:|||||.||:| ...|...|.|.: :|:|.|||||||||||.:|:|:|.|: |.:
Human   353 VWMCGGRMEDIPCSRVGHIYR-KYVPYKVPAGVS-LARNLKRVAEVWMDEYAEYIYQRRPE-YRH 414

  Fly   452 LDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKS 516
            |.|||:..|:.:|..|.||||.||||::|.|....:||||||:.|.|.|:||...: |.|....:
Human   415 LSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGL-CADTKHGA 478

  Fly   517 TEEAVGMFSCADNRTHPQPN--QFWELSIFRDLR------MKGFDSVCLDV--HEGPPNATVWMW 571
            ....:.:..|...|.....|  |.:..:...|:|      .|.|   |.|.  |..|    |.::
Human   479 LGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKF---CFDAISHTSP----VTLY 536

  Fly   572 SCHSQGGNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEFGFVNHTML 636
            .|||..|||.|.| |:.:.|.|..:.. |::  ......::..|:|...:..|:|.|...|.|:|
Human   537 DCHSMKGNQLWKY-RKDKTLYHPVSGS-CMD--CSESDHRIFMNTCNPSSLTQQWLFEHTNSTVL 597

  Fly   637 DTF 639
            :.|
Human   598 EKF 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	128/234 (55%)
		pp-GalNAc-T	181..480	CDD:133004	163/299 (55%)
		Ricin_B_lectin	496..626	CDD:279046	35/139 (25%)
		RICIN	498..628	CDD:238092	35/139 (25%)
GALNT10	NP_938080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..59		7/44 (16%)
		Catalytic subdomain A	144..253		60/110 (55%)
		GT2	145..449	CDD:224137	167/308 (54%)
		pp-GalNAc-T	148..443	CDD:133004	163/299 (55%)
		Catalytic subdomain B	311..373		42/61 (69%)
		Flexible loop	373..384		3/11 (27%)
		Ricin_B_lectin	459..587	CDD:279046	35/139 (25%)
		RICIN	461..589	CDD:238092	35/139 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4048
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1298
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48703
OrthoDB	1	1.010	-	-		D144590at33208
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	1	1.000	-	-		mtm8654
orthoMCL	1	0.900	-	-		OOG6_104854
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2546
SonicParanoid	1	1.000	-	-		X1309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870