Protein Alignment Pgant4 and GALNT9

DIOPT Version :10

• Sequence 1: NP_722910.2
• Gene: Pgant4 / 261610
• FlyBaseID: FBgn0051956
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001116108.1
• Gene: GALNT9 / 50614
• HGNCID: 4131
• Length: 603
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 210/644 - (32%)
• Similarity: 314/644 - (48%)
• Gaps: 86/644 - (13%)

  Fly    13 RKVVLLLVV--IVTVSLVTTLVVERRMKNAAELTEQLDPNGDPITPVFRAANIHPTRKAPRPPFQ 75
            ||:..||.|  :|.|.:|...|..|....:.||...:  :||      |...   :|.|......
Human     5 RKIRTLLTVNILVFVGIVLFSVYCRLQGRSQELVRIV--SGD------RRVR---SRHAKVGTLG 58

  Fly    76 DRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEH 140
            ||.::  :.|.|.|:.....:..|..|   ....:|..   .|.|:.|:|..:.  |:.|..:..
Human    59 DREAI--LQRLDHLEEVVYNQLNGLAK---PIGLVEGP---GGLGQGGLAATLR--DDGQEAEGK 113

  Fly   141 YEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRT 205
            ||..|:|..:|||||::||:||.|...|:...|...||.:||:|||.||..:.:|||::||:|.|
Human   114 YEEYGYNAQLSDRISLDRSIPDYRPRKCRQMSYAQDLPQVSVVFIFVNEALSVILRSVHSVVNHT 178

  Fly   206 PPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVF 270
            |.:|||:::||||.|:...||..||.||.:.:|.||.||||..|:|||.||:.|.|.|...|:.|
Human   179 PSQLLKEVILVDDNSDNVELKFNLDQYVNKRYPGLVKIVRNSRREGLIRARLQGWKAATAPVVGF 243

  Fly   271 FDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDF---SYFSGNKDGARGGFDWKMLYKQL 332
            ||:|:|.|..|..|.:..|..:.:....|.:|.|.:..|   .|.:     |..|::|. |:...
Human   244 FDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYAN-----AAHGYNWG-LWCMY 302

  Fly   333 PVLPEDALDK---SMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGML 394
            .:.|:|.||:   |.|.|:|.|:|..|.::.::|.|:|..|..::::|||..||..::|.|||.:
Human   303 IIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENVELGMRVWQCGGSM 367

  Fly   395 LDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYK--RDPKTYDNLDAGDL 457
            ..:||||||||.| ..||..|...: :..:|..|.||||||::|.:||.  ..|.:...:|.||:
Human   368 EVLPCSRVAHIER-TRKPYNNDIDY-YAKRNALRAAEVWMDDFKSHVYMAWNIPMSNPGVDFGDV 430

  Fly   458 TRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTEEAVG 522
            :.:..:|:||||:||.|::..|.|:.     .|...:...|.::|.....||||...:..:.|:
Human   431 SERLALRQRLKCRSFKWYLENVYPEM-----RVYNNTLTYGEVRNSKASAYCLDQGAEDGDRAI- 489

  Fly   523 MFSCADNRTHPQPNQFWELSIFRDLRMKGF-------DSVCLDVHEGPPNATVWMWSCHSQGGNQ 580
            ::.|     |...:|....|....|::...       ||.|| |.:|...... :..|....
Human   490 LYPC-----HGMSSQLVRYSADGLLQLGPLGSTAFLPDSKCL-VDDGTGRMPT-LKKCEDVA--- 544

  Fly   581 FWYYDRQTQRL--------VHGENNKRCLEGFVE-----NGIAKVVANSCENGNDRQRW 626
                 |.||||        :......||||  ||     |...::|...|..    |:|
Human   545 -----RPTQRLWDFTQSGPIVSRATGRCLE--VEMSKDANFGLRLVVQRCSG----QKW 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_722910.2	pp-GalNAc-T	181..480	CDD:133004	123/306 (40%)
		beta-trefoil_Ricin_Pgant9-like	493..629	CDD:467340	35/154 (23%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		56/110 (51%)
		pp-GalNAc-T	154..453	CDD:133004	123/306 (40%)
		Catalytic subdomain B	318..380		27/61 (44%)
		beta-trefoil_Ricin_GALNT9	456..600	CDD:467351	36/164 (22%)