DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant4 and GALNT9

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001116108.1	Gene:	GALNT9 / 50614	HGNCID:	4131	Length:	603	Species:	Homo sapiens

Alignment Length:	644	Identity:	210/644 - (32%)
Similarity:	314/644 - (48%)	Gaps:	86/644 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RKVVLLLVV--IVTVSLVTTLVVERRMKNAAELTEQLDPNGDPITPVFRAANIHPTRKAPRPPFQ 75
            ||:..||.|  :|.|.:|...|..|....:.||...:  :||      |...   :|.|......
Human     5 RKIRTLLTVNILVFVGIVLFSVYCRLQGRSQELVRIV--SGD------RRVR---SRHAKVGTLG 58

  Fly    76 DRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEH 140
            ||.::  :.|.|.|:.....:..|..|   ....:|..   .|.|:.|:|..:.  |:.|..:..
Human    59 DREAI--LQRLDHLEEVVYNQLNGLAK---PIGLVEGP---GGLGQGGLAATLR--DDGQEAEGK 113

  Fly   141 YEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRT 205
            ||..|:|..:|||||::||:||.|...|:...|...||.:||:|||.||..:.:|||::||:|.|
Human   114 YEEYGYNAQLSDRISLDRSIPDYRPRKCRQMSYAQDLPQVSVVFIFVNEALSVILRSVHSVVNHT 178

  Fly   206 PPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVF 270
            |.:|||:::||||.|:...||..||.||.:.:|.||.||||..|:|||.||:.|.|.|...|:.|
Human   179 PSQLLKEVILVDDNSDNVELKFNLDQYVNKRYPGLVKIVRNSRREGLIRARLQGWKAATAPVVGF 243

  Fly   271 FDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDF---SYFSGNKDGARGGFDWKMLYKQL 332
            ||:|:|.|..|..|.:..|..:.:....|.:|.|.:..|   .|.:     |..|::|. |:...
Human   244 FDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYAN-----AAHGYNWG-LWCMY 302

  Fly   333 PVLPEDALDK---SMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGML 394
            .:.|:|.||:   |.|.|:|.|:|..|.::.::|.|:|..|..::::|||..||..::|.|||.:
Human   303 IIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENVELGMRVWQCGGSM 367

  Fly   395 LDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYK--RDPKTYDNLDAGDL 457
            ..:||||||||.| ..||..|...: :..:|..|.||||||::|.:||.  ..|.:...:|.||:
Human   368 EVLPCSRVAHIER-TRKPYNNDIDY-YAKRNALRAAEVWMDDFKSHVYMAWNIPMSNPGVDFGDV 430

  Fly   458 TRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTEEAVG 522
            :.:..:|:||||:||.|::..|.|:.     .|...:...|.::|.....||||...:..:.|:
Human   431 SERLALRQRLKCRSFKWYLENVYPEM-----RVYNNTLTYGEVRNSKASAYCLDQGAEDGDRAI- 489

  Fly   523 MFSCADNRTHPQPNQFWELSIFRDLRMKGF-------DSVCLDVHEGPPNATVWMWSCHSQGGNQ 580
            ::.|     |...:|....|....|::...       ||.|| |.:|...... :..|....
Human   490 LYPC-----HGMSSQLVRYSADGLLQLGPLGSTAFLPDSKCL-VDDGTGRMPT-LKKCEDVA--- 544

  Fly   581 FWYYDRQTQRL--------VHGENNKRCLEGFVE-----NGIAKVVANSCENGNDRQRW 626
                 |.||||        :......||||  ||     |...::|...|..    |:|
Human   545 -----RPTQRLWDFTQSGPIVSRATGRCLE--VEMSKDANFGLRLVVQRCSG----QKW 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	95/239 (40%)
		pp-GalNAc-T	181..480	CDD:133004	123/306 (40%)
		Ricin_B_lectin	496..626	CDD:279046	34/149 (23%)
		RICIN	498..628	CDD:238092	35/149 (23%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		56/110 (51%)
		pp-GalNAc-T	154..453	CDD:133004	123/306 (40%)
		Catalytic subdomain B	318..380		27/61 (44%)
		Ricin_B_lectin	464..592	CDD:279046	34/149 (23%)
		RICIN	466..594	CDD:238092	35/149 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740