Protein Alignment Pgant4 and GALNTL6

DIOPT Version :10

• Sequence 1: NP_722910.2
• Gene: Pgant4 / 261610
• FlyBaseID: FBgn0051956
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_016863733.1
• Gene: GALNTL6 / 442117
• HGNCID: 33844
• Length: 609
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 245/553 - (44%)
• Similarity: 335/553 - (60%)
• Gaps: 37/553 - (6%)

  Fly   101 RKDWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRL 165
            |||||||.:::.:..|||.||||....:...|.   :...|..||||..:|:.|::.||:||:|.
Human    74 RKDWHDYESIQKEAMRSGKGEHGKPYPLTEEDH---DDSAYRENGFNIFVSNNIALERSLPDIRH 135

  Fly   166 EACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLD 230
            ..||.:.||.:|||.|:|..|.||.:.:|||:|:|:|||||..|:.:|:||||.||.:.||..|:
Human   136 ANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREHLKDKLE 200

  Fly   231 DYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKI 295
            :|:.:.  ..|.|||..:|:|||..|:.||.:|.|:|:.|.|||.|||.||||||:..||:|.|.
Human   201 EYMARF--SKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKT 263

  Fly   296 STCPMVDTISHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPE-DALDKSMPYRSPVMMGGLFAIN 359
            ..|||:|.|.|..|.|.:...|..||.|||:|.||::|:.|| ...|.|.|:.||||.|||||::
Human   264 IVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVD 328

  Fly   360 TDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRG--PMK-PRGNPRGHNF 421
            ..:||:|||||..|:||||||||:|||:|||||.:.|||||||.||:|.  |.| |.|..
Human   329 RKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTS----- 388

  Fly   422 VAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVK 486
            :|:|.|||||.||||:.:|:|:|.|: |.:|..||::.|:.:|::||||.|.|||..||.|....
Human   389 LARNLKRVAETWMDEFAEYIYQRRPE-YRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKY 452

  Fly   487 FPPVEPPSYAAGIIQNVANPVYCLDNMGKSTEEAVGMFSC---ADNRT--HPQPNQF-WELSI-- 543
            :||||||..|.|.|:|||..: |:|:...:|...:.:..|   ...||  |.|...| |...|
Human   453 YPPVEPPPAAWGEIRNVAANL-CVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRP 516

  Fly   544 FRDLRMKGFDSVCLDV--HEGPPNATVWMWSCHSQGGNQFWYYDRQTQRLVHGENNKRCLEGFVE 606
            ...|..:.|   |.|.  |..|    |.::.||...|||.|.| |:.:.|.|..:|. |::  ..
Human   517 GEPLHTRKF---CFDAISHNSP----VTLYDCHGMKGNQLWGY-RKDRTLFHPVSNS-CMD--CN 570

  Fly   607 NGIAKVVANSCENGNDRQRWEFGFVNHTMLDTF 639
            ....|:....|:..::.|:|.|..:|.|:|:.|
Human   571 PAEKKIFMARCDPLSETQQWIFEHINMTVLEKF 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_722910.2	pp-GalNAc-T	181..480	CDD:133004	157/302 (52%)
		beta-trefoil_Ricin_Pgant9-like	493..629	CDD:467340	41/145 (28%)
GALNTL6	XP_016863733.1	pp-GalNAc-T	151..446	CDD:133004	157/302 (52%)
		beta-trefoil_Ricin_GALNTL6	457..604	CDD:467355	48/159 (30%)