DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and GALNT8

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_059113.1	Gene:	GALNT8 / 26290	HGNCID:	4130	Length:	637	Species:	Homo sapiens

Alignment Length:	701	Identity:	197/701 - (28%)
Similarity:	303/701 - (43%)	Gaps:	185/701 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKKRY---VKRLLRKVVLLLVVIVTVSLVTTLVVERRMKNAAELTEQLDPNGDPITPVFRA--AN 62
            :.|||   :|||....|.|..:..::.|..     |:.:|   :...|....|.:.|:.:|  ..
Human    49 LNKRYGAVIKRLSHLEVELQDLKESMKLAL-----RQQEN---VNSTLKRAKDEVRPLLKAMETK 105

  Fly    63 IHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVK 127
            ::.|:|       .:..:...|.|   |.||         .|.:..: ||.:|.:
Human   106 VNETKK-------HKTQMKLFPHS---QLFR---------QWGEDLS-EAQQKAA---------- 140

  Fly   128 IENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFN 192
                      ::.:...|:|..:|:::.:||::||.|...|..:.|.::||::|||.||.||..:
Human   141 ----------QDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALS 195

  Fly   193 TLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQ---QHFPHLVTIVRNPERQGLIG 254
            .:.|:|.|:|||||..|||:|:||||.|....||..||:.::   |.:|.|:.|:|:|||:||..
Human   196 IIQRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQ 260

  Fly   255 ARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGA 319
            ||..|.:.|...|:...|:|||||..|..|::..|..:..:...|:.|.|..:.|..  ...:.|
Human   261 ARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKL--DKYELA 323

  Fly   320 RGGFDWKM--LYKQLPVLPEDALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYE 382
            ..||:|::  .|..||....|..|.:.|.:||.:| |:.|.|..|..::|..|..:.|:|||..|
Human   324 VDGFNWELWCRYDALPQAWIDLHDVTAPVKSPSIM-GILAANRHFLGEIGSLDGGMLIYGGENVE 387

  Fly   383 LSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVA---KNHKRVAEVWMDEYKQYVYK- 443
            ||.::|.|||.:..:||||:||:.|     ...|...:..|   :|..||||:||||:|..||.
Human   388 LSLRVWQCGGKVEILPCSRIAHLER-----HHKPYALDLTAALKRNALRVAEIWMDEHKHMVYLA 447

  Fly   444 -RDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPV 507
             ..|.....:|.||::.:..:||:||||:|.|::..|.|  |:|                   |:
Human   448 WNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYP--LLK-------------------PL 491

  Fly   508 YCLDNMGKSTEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGF--DSVCLDVHEGP-PNATVW 569
            :.:...|                                 |||..  ::||||  :|| |..|..
Human   492 HTIVGYG---------------------------------RMKNLLDENVCLD--QGPVPGNTPI 521

  Fly   570 MWSCHSQGGNQFWYY-----------------DR-------------------QTQRL------- 591
            |:.||.......:|:                 ||                   ...||
Human   522 MYYCHEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDFK 586

  Fly   592 ----VHGENNKRCLEGFVE-NGIAKVVANSCENGNDRQRWEFGFVNHTMLD 637
                |...:.|||||...: .|...:|..:|..    |.||   :.||:.|
Human   587 PGGAVINRDTKRCLEMKKDLLGSHVLVLQTCST----QVWE---IQHTVRD 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	93/238 (39%)
		pp-GalNAc-T	181..480	CDD:133004	119/308 (39%)
		Ricin_B_lectin	496..626	CDD:279046	31/180 (17%)
		RICIN	498..628	CDD:238092	32/180 (18%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		26/146 (18%)
		SMC_N	<48..>161	CDD:330553	29/159 (18%)
		GT1 motif	182..298		52/115 (45%)
		pp-GalNAc-T	184..485	CDD:133004	119/308 (39%)
		Gal/GalNAc transferase motif	358..397		16/39 (41%)
		RICIN	498..624	CDD:238092	32/167 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810