DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and GALNT3

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_004473.2	Gene:	GALNT3 / 2591	HGNCID:	4125	Length:	633	Species:	Homo sapiens

Alignment Length:	673	Identity:	220/673 - (32%)
Similarity:	338/673 - (50%)	Gaps:	106/673 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKKRYVKRLLRKVVLLLVVIVTVSLVTTLV----------VERRMKNAAELTEQLDPNGDPITPV 57
            ||:.|.|:..:...::...|:.:.|:...|          :||.|||..::.:.:      :..|
Human    12 IKRHYHKKFWKLGAVIFFFIIVLVLMQREVSVQYSKEESRMERNMKNKNKMLDLM------LEAV 70

  Fly    58 FRAANIHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAME----ADR---K 115
            ....:..|..:...|..|:    :|......|||:              |.|.|    .||   .
Human    71 NNIKDAMPKMQIGAPVRQN----IDAGERPCLQGY--------------YTAAELKPVLDRPPQD 117

  Fly   116 RSGFGEHGVAVKIENPD-EKQLEKEHYE-MNGFNGLISDRISVNRSV-PDLRLEACKTRKY--LA 175
            .:..|..|.|.|..|.. |:|.|||..| .:.||...|||||::|.: ||.|...|..:|:  ..
Human   118 SNAPGASGKAFKTTNLSVEEQKEKERGEAKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCP 182

  Fly   176 KLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHL 240
            .||..|||.:|.||.::||||:::||:..:|..|||:|:||||.|..:.|...||:||:|.  .:
Human   183 PLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDKLDEYVKQF--SI 245

  Fly   241 VTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTIS 305
            |.|||..||:|||.||:.||.||..:.:.|.|:|.|..|.||.||:..||.|......|.:.:|
Human   246 VKIVRQRERKGLITARLLGATVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASI- 309

  Fly   306 HEDFSYFSGNKDGA------RGGFDWKMLY--KQLPVLPED-ALDKSMPYRSPVMMGGLFAINTD 361
              |.:.|..||...      ||.|||.:.:  :.||...:. ..|::.|.::|...||||:|:.:
Human   310 --DLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETYPIKTPTFAGGLFSISKE 372

  Fly   362 FFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNH 426
            :|..:|.||::::|||||..|:||::|.|||.|..:|||.|.|:||. ..|...|:|...:|:|.
Human   373 YFEYIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRS-KSPHSFPKGTQVIARNQ 436

  Fly   427 KRVAEVWMDEYKQYVYKRDPKTYDNLDA---------GDLTRQRGVRERLKCKSFHWFMTEVAPD 482
            .|:|||||||||:..|:|      |.||         |||:::..::.||:||:|.|::..:.|:
Human   437 VRLAEVWMDEYKEIFYRR------NTDAAKIVKQKAFGDLSKRFEIKHRLQCKNFTWYLNNIYPE 495

  Fly   483 FLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTE--EAVGMFSCADNRTHP-QPNQFWELSIF 544
            ..|  |.:.|  ..:|.|::|..|: ||| :|::.:  :.:.|::|     |. ..||::|.|..
Human   496 VYV--PDLNP--VISGYIKSVGQPL-CLD-VGENNQGGKPLIMYTC-----HGLGGNQYFEYSAQ 549

  Fly   545 RDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQG------GNQFWYYDRQTQRLVHGENNKRCLEG 603
            .::|......:||...:|    .|.:.:|..:|      |.|.|  :.|..:|::....|.||..
Human   550 HEIRHNIQKELCLHAAQG----LVQLKACTYKGHKTVVTGEQIW--EIQKDQLLYNPFLKMCLSA 608

  Fly   604 FVENGIAKVVANSCENGNDRQRW 626
               ||....:. ||...:..|:|
Human   609 ---NGEHPSLV-SCNPSDPLQKW 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	99/244 (41%)
		pp-GalNAc-T	181..480	CDD:133004	129/316 (41%)
		Ricin_B_lectin	496..626	CDD:279046	35/138 (25%)
		RICIN	498..628	CDD:238092	36/138 (26%)
GALNT3	NP_004473.2	Catalytic subdomain A	184..293		54/110 (49%)
		pp-GalNAc-T	188..493	CDD:133004	129/316 (41%)
		Catalytic subdomain B	356..418		29/61 (48%)
		Ricin_B_lectin	506..627	CDD:306998	35/137 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810