DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant4 and Galnt18

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_776100.2	Gene:	Galnt18 / 233733	MGIID:	2446239	Length:	622	Species:	Mus musculus

Alignment Length:	704	Identity:	190/704 - (26%)
Similarity:	305/704 - (43%)	Gaps:	180/704 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RYVKRLLRKVVLL-----LVVIVTVSLVTTLV---------------VERRMKNAAELTEQLDPN 50
            |..|.|:...|:|     ::.::.|..||..:               :|....:..::.|:||..
Mouse     5 RKTKTLVSTCVILSGMTNIICLLYVGWVTNYIASVYVRGQEPVPDKKLEEDKGDTLKIIERLDHL 69

  Fly    51 GDPITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRK 115
            .:.|....:.|...| .:|...||.|
Mouse    70 ENVIKQHIQEAPAKP-EEAEAEPFTD--------------------------------------- 94

  Fly   116 RSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNI 180
            .|.|...|..:   :|:.:::..:.::..|:|..:|||:.::|.:||||...|:...:...||.:
Mouse    95 SSLFAHWGQEL---SPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSFPDSLPEV 156

  Fly   181 SVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQ---HFPHLVT 242
            |::|||.||..:.|||||:|.:.|||..|||:|:||||.|..:.||:.|.:||.:   ..|..:.
Mouse   157 SIVFIFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLTEYVDKVNGQKPGFIK 221

  Fly   243 IVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHE 307
            :||:.:::|||.:|::|.:.|...|:..||:|:|.|..|..|::..|..|.|....|..|.|.::
Mouse   222 VVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYD 286

  Fly   308 DFSYFSGNKDGARGGFDWKMLYKQLPVLPEDA---LDKS-MPYRSPVMMGGLFAINTDFFWDLGG 368
            :|..  .....|..||||::..:.|.  |..|   |:.| .|.|||.:: |.|.::..:|.::|.
Mouse   287 NFEI--EEYPLAAQGFDWELWCRYLN--PPKAWWKLENSTAPIRSPALI-GCFIVDRQYFEEIGL 346

  Fly   369 YDDQLDIWGGEQYELSFK---------------IWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRG 418
            .|:.::::|||..||..:               :|.|||.:..:||||:|||.|.......:...
Mouse   347 LDEGMEVYGGENVELGIRVSEISHTGLSSAPMMVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTA 411

  Fly   419 HNFVAKNHKRVAEVWMDEYKQYVYK--RDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAP 481
            |  |.:|..|||||||||:|.:||.  ..|:....:|.||:|.::.:|::|:||:|.|::..|.|
Mouse   412 H--VRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYP 474

  Fly   482 DFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTEEAVGMFSC-------------------- 526
            :..:....:     |.|::||......||| .|..||....::.|
Mouse   475 EMRMYSDII-----AYGVLQNSLKTDLCLD-QGPDTENVPIVYICHGMTPQNVYYTSSQQIHVGI 533

  Fly   527 -------ADNRTHPQPN---QFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQGGNQF 581
                   .|||.....|   :..|.|..:..|||        :|        |.:   ||||:
Mouse   534 LSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMK--------LH--------WQF---SQGGS-- 577

  Fly   582 WYYDRQTQRLVHGENNKRCLE---------GFVENGIAKVVANSCENGNDRQRW 626
                      :....:|||||         ||      ::|...|..    |.|
Mouse   578 ----------IQNRKSKRCLELQENSDMEFGF------QLVLQKCSG----QHW 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	87/255 (34%)
		pp-GalNAc-T	181..480	CDD:133004	115/322 (36%)
		Ricin_B_lectin	496..626	CDD:279046	36/168 (21%)
		RICIN	498..628	CDD:238092	36/168 (21%)
Galnt18	NP_776100.2	Catalytic subdomain A	153..267		48/113 (42%)
		pp-GalNAc-T	157..473	CDD:133004	115/322 (36%)
		Catalytic subdomain B	324..400		25/76 (33%)
		Ricin_B_lectin	484..611	CDD:279046	36/168 (21%)
		RICIN	486..613	CDD:238092	36/168 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810